CCK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XOU

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41421-022-00420-3

PUBLICATION DATE

July 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

65 interactions (Click to see)

LIGANDS

CCK-8 - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

CCK-8, desulfated cholecystokinin-8, CCK-39, CCK-58, CCK-33, CCK-4, gastrin-17



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 311 6x33 G.H5 Y 391 G.H5.23
Polar ICL2 Q 148 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 Q 148 - G.s2s3 D 215 G.s2s3.01
Aromatic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 147 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 147 - G.H5 R 380 G.H5.12
Hydrophobic ICL4 K 375 - G.H5 Q 390 G.H5.22
Polar TM6 N 304 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 N 304 6x26 G.h4s6 Y 358 G.h4s6.20
Polar TM2 T 76 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM2 T 76 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM6 N 304 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 N 304 6x26 G.H5 R 385 G.H5.17
Hydrophobic ICL2 Q 148 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 Q 148 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 147 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 147 - G.S1 H 41 G.S1.02
Polar ICL2 R 150 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 150 - G.S1 H 41 G.S1.02
Hydrophobic TM6 R 310 6x32 G.H5 L 393 G.H5.25
Van-der-waals ICL2 R 150 - G.H5 M 386 G.H5.18
Hydrophobic TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 143 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 150 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 R 150 - G.H5 I 383 G.H5.15
Polar TM3 C 144 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 146 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 146 - G.H5 R 380 G.H5.12
Hydrophobic TM6 A 307 6x29 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 147 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 147 - G.H5 I 383 G.H5.15
Hydrophobic TM6 S 301 6x23 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 S 301 6x23 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 V 151 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 V 151 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 R 150 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL4 N 374 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 146 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 146 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 147 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 147 - G.H5 F 376 G.H5.08
Hydrophobic ICL4 N 374 - G.H5 L 393 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 R 150 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 150 - G.H5 H 387 G.H5.19
Polar ICL4 K 375 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 K 375 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 K 375 - G.H5 E 392 G.H5.24
Polar ICL2 P 146 - G.H5 H 387 G.H5.19
Hydrophobic TM6 V 311 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL4 M 373 - G.H5 L 393 G.H5.25
Van-der-waals ICL4 M 373 - G.H5 L 393 G.H5.25
Hydrophobic TM5 L 236 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM4 T 154 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 154 4x38 G.HN Q 35 G.HN.52