sulpiride


SMILES CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N
InChIKey BGRJTUBHPOOWDU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 341.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations D1 D2 D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Bovine Dopamine A pKi 4.3 4.3 4.3 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.68 5.68 5.68 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.57 7.33 8.26 ChEMBL
D2 DRD2 Rat Dopamine A pKd 8.82 8.82 8.82 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.92 7.29 8.1 ChEMBL
D3 DRD3 Human Dopamine A pKd 7.4 7.4 7.4 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.92 7.33 8.12 ChEMBL
D2 DRD2 Human Dopamine A pKd 8.55 8.55 8.55 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.32 7.8 8.19 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.26 7.39 8.38 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.09 8.12 8.14 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.31 6.23 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.32 5.32 5.32 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 6.12 6.12 6.12 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.28 7.64 8.0 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.09 8.12 8.15 Drug Central
D1 DRD1 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.68 7.55 7.85 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 8.25 8.25 8.25 Drug Central
D4 DRD4 Human Dopamine A pKi 5.7 6.64 7.7 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.72 6.19 7.7 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
BB3 BRS3 Human Bombesin A pKi 5.0 5.16 5.32 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 6.37 7.53 9.15 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 5.89 7.09 7.84 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 8.37 8.37 8.37 Drug Central
D1 DRD1 Bovine Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.3 5.41 5.52 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 5.0 6.14 7.28 PDSP Ki database
D2 DRD2 Rat Dopamine A pKd 8.05 8.05 8.05 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.09 8.09 8.09 Drug Central
D2 DRD2 Rat Dopamine A pKi 5.0 7.25 9.68 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
D1 DRD1 Mouse Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.0 5.04 5.14 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 6.63 6.9 7.48 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.25 6.78 7.18 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.69 7.24 7.99 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.7 5.7 5.7 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL
D2 DRD2 Dog Dopamine A pIC50 8.17 8.17 8.17 Drug Central
D2 DRD2 Dog Dopamine A pIC50 6.7 6.7 6.7 ChEMBL