Afamelanotide

Chemical Properties

SMILES None
Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight

Drug Properties

Type Peptide
Endogenous No
Approved Yes
InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N

Database Connections

External Links
Structure pdb 7F54 7PIV
Ligand site mutations MC4


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pIC50 10.0 10.0 10.0 Guide to Pharmacology
MC3 MC3R Human Melanocortin A pKi 8.9 8.9 8.9 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 8.5 8.65 8.8 Guide to Pharmacology
MC5 MC5R Human Melanocortin A pIC50 9.0 9.0 9.0 Guide to Pharmacology
MC3 MC3R Rat Melanocortin A pEC50 10.0 10.0 10.0 ChEMBL
MC5 MC5R Mouse Melanocortin A pEC50 6.77 9.76 10.52 ChEMBL
MC5 MC5R Mouse Melanocortin A pIC50 6.85 6.85 6.85 ChEMBL
MC3 MC3R Mouse Melanocortin A pEC50 7.12 9.75 10.2 ChEMBL
MC3 MC3R Mouse Melanocortin A pIC50 8.09 8.25 8.38 ChEMBL
MC1 MSHR Mouse Melanocortin A pEC50 7.92 10.41 11.0 ChEMBL
MC1 MSHR Mouse Melanocortin A pIC50 9.51 9.52 9.54 ChEMBL
MC4 MC4R Mouse Melanocortin A pEC50 6.92 9.46 10.01 ChEMBL
MC4 MC4R Mouse Melanocortin A pIC50 8.38 8.73 8.96 ChEMBL
MC1 MSHR Human Melanocortin A pKi 8.74 9.46 10.34 ChEMBL
MC1 MSHR Human Melanocortin A pEC50 9.3 9.95 10.64 ChEMBL
MC1 MSHR Human Melanocortin A pIC50 9.29 9.29 9.29 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 8.66 8.9 9.07 ChEMBL
MC5 MC5R Human Melanocortin A pEC50 8.96 9.21 9.64 ChEMBL
MC5 MC5R Human Melanocortin A pKi 8.0 8.66 9.32 ChEMBL
MC3 MC3R Human Melanocortin A pKi 9.11 9.14 9.17 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 8.17 9.15 9.89 ChEMBL
MC3 MC3R Human Melanocortin A pIC50 8.42 8.63 8.93 ChEMBL
MC4 MC4R Human Melanocortin A pKi 7.72 9.0 9.52 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.05 9.27 10.77 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 7.85 8.96 9.82 ChEMBL