tandospirone


SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1
InChIKey CEIJFEGBUDEYSX-FZDBZEDMSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 8.14 8.14 8.14 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.5 7.87 8.24 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.12 8.12 8.12 Drug Central
D2 DRD2 Human Dopamine A pKi 6.34 6.95 7.55 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.09 8.09 8.09 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.05 8.05 8.05 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database