7-Oh-Dpat


SMILES CCCN(C1CCc2c(C1)cc(cc2)O)CCC
InChIKey BLYMJBIZMIGWFK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 247.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 5.6 6.6 7.6 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 7.1 7.75 8.4 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKd 9.6 9.6 9.6 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKd 9.1 9.1 9.1 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKi 8.21 8.47 8.93 ChEMBL
D3 DRD3 Rat Dopamine A pKd 9.17 9.17 9.17 ChEMBL
D3 DRD3 Rat Dopamine A pIC50 8.9 8.93 8.96 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.83 6.83 6.83 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.51 7.03 8.6 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 6.72 7.0 7.52 ChEMBL
D2 DRD2 Rat Dopamine A pEC50 8.73 8.73 8.73 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.55 6.34 7.14 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.33 7.33 7.33 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.85 8.07 8.85 ChEMBL
D3 DRD3 Human Dopamine A pEC50 9.02 9.15 9.28 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.84 6.95 8.64 ChEMBL
D2 DRD2 Human Dopamine A pEC50 7.4 7.4 7.4 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 4.99 4.99 4.99 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 4.75 6.06 7.57 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.25 7.55 8.41 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.58 5.94 6.29 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.42 6.2 7.03 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 7.41 7.65 7.89 PDSP Ki database
H1 HRH1 Human Histamine A pKi 4.82 4.82 4.82 PDSP Ki database