GPCRdb

(±)-adrenaline

(±)-adrenaline

SMILES	CNCC(O)c1ccc(O)c(O)c1
InChIKey	UCTWMZQNUQWSLP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	3
Molecular weight (Da)	183.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	β₁ β₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.03	5.03	5.03	PDSP Ki database
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.20	5.70	6.20	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.80	6.00	6.20	Guide to Pharmacology
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	Guide to Pharmacology
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₃	ADRB3	Human	Adrenoceptors	A	pKi	3.90	4.30	4.70	Guide to Pharmacology
β₃	ADRB3	Rat	Adrenoceptors	A	pKi	5.30	5.30	5.30	Guide to Pharmacology
β₃	Q3UP63	Mouse	Adrenoceptors	A	pKi	5.30	5.30	5.30	Guide to Pharmacology
D₁	DRD1	Bovine	Dopamine	A	pKi	5.92	5.92	5.92	PDSP Ki database
D₂	DRD2	Bovine	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.58	5.58	5.58	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.50	5.50	5.50	ChEMBL

Showing 1 to 2 of 2 entries

(±)-adrenaline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	β₁ β₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADRB2	β₂-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.612	4	Yes
ADRB3	β₃-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes

Showing 1 to 9 of 9 entries

This ligand is endogenous.