mianserin
| SMILES | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 |
| InChIKey | UEQUQVLFIPOEMF-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 0 |
| Molecular weight (Da) | 264.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.7 | 8.65 | 9.6 | Guide to Pharmacology |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.9 | 8.35 | 8.8 | Guide to Pharmacology |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.3 | 8.75 | 9.2 | Guide to Pharmacology |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.9 | 7.1 | 7.3 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 7.3 | 7.45 | 7.6 | Guide to Pharmacology |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.6 | 7.6 | 7.6 | Guide to Pharmacology |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.5 | 7.5 | 7.5 | Guide to Pharmacology |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.9 | 7.15 | 7.4 | Guide to Pharmacology |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.4 | 8.7 | 9.0 | Guide to Pharmacology |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.8 | 9.1 | 9.4 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.0 | 7.0 | Guide to Pharmacology |
| 5-HT1B | 5HT1B | Mouse | 5-Hydroxytryptamine | A | pKi | 8.3 | 8.3 | 8.3 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.2 | 7.4 | Guide to Pharmacology |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 7.77 | 7.77 | 7.77 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 7.37 | 7.37 | 7.37 | ChEMBL |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.1 | 7.2 | ChEMBL |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 5.82 | 5.82 | 5.82 | ChEMBL |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.85 | 8.85 | 8.85 | ChEMBL |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 5.85 | 5.85 | 5.85 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 9.07 | 9.07 | 9.07 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.33 | 5.33 | 5.33 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 7.18 | 7.18 | 7.18 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.04 | 7.04 | 7.04 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.39 | 7.39 | 7.39 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.62 | 7.62 | 7.62 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 6.64 | 6.64 | 6.64 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.58 | 8.0 | 8.42 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 5.1 | 6.52 | 7.25 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.77 | 9.27 | 9.76 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 6.53 | 6.53 | 6.53 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 6.0 | 6.04 | 6.08 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKd | 6.6 | 6.6 | 6.6 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.3 | 6.3 | 6.3 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.8 | 8.06 | 8.32 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 6.57 | 6.57 | 6.57 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.26 | 7.33 | 7.4 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.33 | 8.33 | 8.33 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.42 | 6.42 | 6.42 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.0 | 8.46 | 9.22 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 6.46 | 6.46 | 6.46 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 5.55 | 5.55 | 5.55 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.57 | 8.43 | 9.3 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKd | 6.4 | 6.4 | 6.4 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.66 | 5.66 | 5.66 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.53 | 9.2 | PDSP Ki database |
| 5-HT2C | 5HT2C | Dog | 5-Hydroxytryptamine | A | pKi | 8.55 | 8.55 | 8.55 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.96 | 8.62 | 9.4 | PDSP Ki database |
| 5-HT2C | 5HT2C | Mouse | 5-Hydroxytryptamine | A | pKi | 8.62 | 8.62 | 8.62 | PDSP Ki database |
| 5-HT2C | K7GSR7 | Pig | 5-Hydroxytryptamine | A | pKi | 5.9 | 7.91 | 8.41 | PDSP Ki database |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.22 | 5.55 | PDSP Ki database |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.4 | 6.53 | 6.66 | PDSP Ki database |
| 5-HT1D | F1MMU1 | Bovine | 5-Hydroxytryptamine | A | pKi | 6.32 | 6.37 | 6.4 | PDSP Ki database |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 7.79 | 8.44 | 9.26 | PDSP Ki database |
| D1 | DRD1 | Human | Dopamine | A | pKi | 5.85 | 6.11 | 6.37 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.57 | 5.71 | 5.89 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.59 | 6.15 | 6.4 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.25 | 8.18 | 8.8 | PDSP Ki database |
| 5-HT2A | 5HT2A | Bovine | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | PDSP Ki database |
| 5-HT2A | 5HT2A | Pig | 5-Hydroxytryptamine | A | pKi | 7.44 | 7.44 | 7.44 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.91 | 7.29 | 7.42 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 6.89 | 7.43 | PDSP Ki database |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.09 | 7.2 | 7.26 | PDSP Ki database |
| 5-HT1D | 5HT1D | Rat | 5-Hydroxytryptamine | A | pKi | 7.52 | 7.52 | 7.52 | PDSP Ki database |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.7 | 8.12 | 8.8 | PDSP Ki database |
| 5-HT2B | 5HT2B | Rat | 5-Hydroxytryptamine | A | pKi | 6.7 | 7.17 | 7.3 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.34 | 7.98 | 8.32 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.58 | 7.76 | 8.42 | PDSP Ki database |
| α2C | ADA2C | North American opossum | Adrenoceptors | A | pKi | 6.72 | 7.54 | 8.35 | PDSP Ki database |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 7.34 | 7.59 | 7.85 | PDSP Ki database |
| 5-HT7 | 5HT7R | Guinea pig | 5-Hydroxytryptamine | A | pKi | 6.18 | 6.57 | 6.97 | PDSP Ki database |
| 5-HT6 | 5HT6R | Mouse | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.73 | 8.49 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 5.0 | 8.43 | 9.52 | PDSP Ki database |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.12 | 6.12 | 6.12 | PDSP Ki database |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.6 | 6.05 | 6.5 | PDSP Ki database |
| 5-HT1F | 5HT1F | Mouse | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.0 | 7.0 | PDSP Ki database |
| 5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.0 | 7.0 | PDSP Ki database |
| 5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 7.9 | 7.9 | 7.9 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.0 | 5.66 | 6.17 | PDSP Ki database |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 6.21 | 6.21 | 6.21 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 8.39 | 8.71 | 9.0 | PDSP Ki database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.38 | 8.38 | 8.38 | PDSP Ki database |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 5.1 | 6.17 | 7.25 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 5.55 | 5.55 | 5.55 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| 5-HT1F | 5HT1F | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.03 | 8.03 | 8.03 | Drug Central |
| H2 | HRH2 | Human | Histamine | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
| 5-HT7 | 5HT7R | Mouse | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| 5-HT1B | 5HT1B | Mouse | 5-Hydroxytryptamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 6.54 | 6.54 | 6.54 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.57 | 7.57 | 7.57 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT2B | 5HT2B | Rat | 5-Hydroxytryptamine | A | pKi | 7.3 | 7.3 | 7.3 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M5 | ACM5 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 5.72 | 5.72 | 5.72 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 6.92 | 6.92 | 6.92 | ChEMBL |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pIC50 | 6.42 | 6.42 | 6.42 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 6.65 | 8.4 | 10.15 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 7.08 | 7.08 | 7.08 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.28 | 7.28 | 7.28 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.5 | 6.5 | 6.5 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.75 | 7.16 | 7.37 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pIC50 | 6.0 | 6.0 | 6.0 | ChEMBL |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pIC50 | 6.94 | 6.94 | 6.94 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 8.47 | 8.64 | 8.82 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.85 | 5.85 | 5.85 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 5.45 | 5.45 | 5.45 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pIC50 | 5.48 | 5.48 | 5.48 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 6.39 | 6.39 | 6.39 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 6.06 | 6.06 | 6.06 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 7.37 | 7.53 | 7.68 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.26 | 6.26 | 6.26 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 7.07 | 7.07 | 7.07 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 8.14 | 8.14 | 8.14 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.97 | 5.97 | 5.97 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 8.13 | 8.54 | 8.94 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.85 | 5.85 | 5.85 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 5.41 | 5.41 | 5.41 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 7.68 | 8.14 | 8.75 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pIC50 | 6.4 | 6.4 | 6.4 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pIC50 | 5.15 | 5.15 | 5.15 | ChEMBL |
| M5 | ACM5 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 8.24 | 8.24 | 8.24 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 8.19 | 8.19 | 8.19 | Drug Central |
| D4 | DRD4 | Human | Dopamine | A | pIC50 | 8.26 | 8.26 | 8.26 | Drug Central |
| H4 | HRH4 | Human | Histamine | A | pEC50 | 8.21 | 8.21 | 8.21 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 7.99 | 7.99 | 7.99 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.68 | 5.68 | 5.68 | ChEMBL |
| LPA1 | LPAR1 | Human | Lysophospholipid (LPA) | A | pIC50 | 7.0 | 7.0 | 7.0 | Guide to Pharmacology |