sulprostone


SMILES O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O
InChIKey UQZVCDCIMBLVNR-TWYODKAFSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 12
Molecular weight (Da) 465.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP1 PE2R1 Human Prostanoid A pKi 6.9 6.95 7.0 Guide to Pharmacology
EP3 PE2R3 Human Prostanoid A pKi 9.46 9.46 9.46 Guide to Pharmacology
FP PF2R Human Prostanoid A pKi 6.7 6.7 6.7 Guide to Pharmacology
EP1 PE2R1 Mouse Prostanoid A pKi 7.7 7.7 7.7 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 9.15 9.15 9.15 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKi 9.2 9.2 9.2 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKi 7.0 7.0 7.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP3 PE2R3 Human Prostanoid A pEC50 8.85 8.85 8.85 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pEC50 9.38 9.38 9.38 Guide to Pharmacology