cebranopadol


SMILES Fc1ccc2c(c1)c1CCOC3(c1[nH]2)CCC(CC3)(N(C)C)c1ccccc1
InChIKey CSMVOZKEWSOFER-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 378.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.74 7.74 7.74 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.59 8.59 8.59 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.15 9.15 9.15 Guide to Pharmacology
NOP OPRX Human Opioid A pKi 9.05 9.05 9.05 Guide to Pharmacology
μ OPRM Rat Opioid A pKi 8.62 8.62 8.62 Guide to Pharmacology
NOP OPRX Rat Opioid A pKi 9.0 9.0 9.0 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.19 7.19 7.19 Guide to Pharmacology
NOP OPRX Human Opioid A pKi 7.01 8.37 9.05 ChEMBL
δ OPRD Human Opioid A pKi 7.75 7.75 7.75 ChEMBL
μ OPRM Human Opioid A pKi 7.34 8.48 9.15 ChEMBL
κ OPRK Human Opioid A pKi 8.59 8.59 8.59 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pEC50 7.89 7.89 7.89 Guide to Pharmacology
NOP OPRX Human Opioid A pEC50 7.89 7.89 7.89 ChEMBL
μ OPRM Human Opioid A pEC50 8.92 8.92 8.92 ChEMBL