GPCRdb

PGF_2α

PGF_2α

SMILES	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O
InChIKey	PXGPLTODNUVGFL-YNNPMVKQSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	12
Molecular weight (Da)	354.2

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	8XJL 8IUK

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

DP₁	PD2R	Human	Prostanoid	A	pKi	6.10	6.25	6.40	Guide to Pharmacology
DP₁	PD2R	Human	Prostanoid	A	pKi	6.06	6.06	6.06	PDSP Ki database
DP₁	PD2R	Rat	Prostanoid	A	pKi	6.16	6.16	6.16	PDSP Ki database
DP₂	PD2R2	Human	Prostanoid	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
DP₂	PD2R2	Mouse	Prostanoid	A	pKi	6.20	6.20	6.20	Guide to Pharmacology
DP₂	PD2R2	Human	Prostanoid	A	pKi	8.19	8.19	8.19	Drug Central
DP₂	PD2R2	Mouse	Prostanoid	A	pKi	8.21	8.21	8.21	Drug Central
EP₁	PE2R1	Human	Prostanoid	A	pKi	6.20	6.25	6.30	Guide to Pharmacology
EP₁	PE2R1	Mouse	Prostanoid	A	pKi	5.90	5.90	5.90	Guide to Pharmacology
EP₁	PE2R1	Rat	Prostanoid	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
EP₁	PE2R1	Mouse	Prostanoid	A	pKi	5.89	5.89	5.89	PDSP Ki database
EP₁	PE2R1	Mouse	Prostanoid	A	pKi	8.23	8.23	8.23	Drug Central
EP₁	PE2R1	Rat	Prostanoid	A	pKi	8.19	8.19	8.19	Drug Central
EP₁	PE2R1	Human	Prostanoid	A	pKi	6.26	6.26	6.26	PDSP Ki database
EP₂	PE2R2	Human	Prostanoid	A	pKi	5.20	5.60	6.00	Guide to Pharmacology
EP₂	PE2R2	Rat	Prostanoid	A	pKi	5.60	5.60	5.60	Guide to Pharmacology
EP₂	PE2R2	Human	Prostanoid	A	pKi	8.22	8.22	8.22	Drug Central
EP₂	PE2R2	Rat	Prostanoid	A	pKi	8.25	8.25	8.25	Drug Central
EP₃	PE2R3	Human	Prostanoid	A	pKi	7.42	7.42	7.42	Guide to Pharmacology
EP₃	PE2R3	Rat	Prostanoid	A	pKi	6.67	6.67	6.67	Guide to Pharmacology

Showing 1 to 20 of 43 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

DP₁	PD2R	Human	Prostanoid	A	pIC50	8.27	8.27	8.27	Drug Central
DP₁	PD2R	Human	Prostanoid	A	pIC50	5.35	5.35	5.35	ChEMBL
EP₁	PE2R1	Human	Prostanoid	A	pIC50	6.42	6.54	6.66	ChEMBL
EP₁	PE2R1	Human	Prostanoid	A	pEC50	6.22	6.22	6.22	ChEMBL
EP₁	PE2R1	Human	Prostanoid	A	pIC50	8.18	8.18	8.18	Drug Central
EP₃	PE2R3	Rat	Prostanoid	A	pEC50	8.38	8.38	8.38	Guide to Pharmacology
EP₃	PE2R3	Human	Prostanoid	A	pIC50	6.49	6.72	6.96	ChEMBL
EP₃	PE2R3	Human	Prostanoid	A	pEC50	5.64	5.64	5.64	ChEMBL
EP₃	PE2R3	Human	Prostanoid	A	pIC50	8.16	8.16	8.16	Drug Central
EP₃	PE2R3	Rat	Prostanoid	A	pEC50	8.08	8.08	8.08	Drug Central
EP₄	PE2R4	Human	Prostanoid	A	pEC50	6.05	6.05	6.05	Guide to Pharmacology
EP₄	PE2R4	Human	Prostanoid	A	pIC50	8.27	8.27	8.27	Drug Central
EP₄	PE2R4	Human	Prostanoid	A	pIC50	5.38	5.38	5.38	ChEMBL
FP	PF2R	Bovine	Prostanoid	A	pIC50	6.85	6.85	6.85	ChEMBL
FP	PF2R	Mouse	Prostanoid	A	pEC50	7.61	7.76	7.90	ChEMBL
FP	PF2R	Human	Prostanoid	A	pEC50	7.10	7.36	7.61	ChEMBL
FP	PF2R	Human	Prostanoid	A	pIC50	7.37	8.16	8.60	ChEMBL
FP	PF2R	Mouse	Prostanoid	A	pEC50	8.10	8.10	8.10	Drug Central
TP	TA2R	Human	Prostanoid	A	pEC50	5.85	5.85	5.85	ChEMBL

Showing 1 to 19 of 19 entries

PGF_2α

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	8XJL 8IUK

Compound is not listed as a drug.

This ligand is endogenous.