GAL1 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

May 3, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

galanin-like peptide, galanin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar H8 N 309 8x49 G.H5 R 349 G.H5.21
Hydrophobic H8 E 308 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 E 308 8x48 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 137 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 137 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Polar TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 351 G.H5.23
Polar TM6 S 235 6x23 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 241 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 S 241 6x29 G.H5 L 348 G.H5.20
Polar ICL3 N 233 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 N 233 - G.H5 D 337 G.H5.09
Polar H8 S 307 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 307 8x47 G.H5 G 352 G.H5.24
Polar TM6 K 236 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 236 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 236 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 240 6x28 G.H5 Y 354 G.H5.26
Hydrophobic TM6 S 241 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 T 245 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 T 245 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 226 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 226 5x64 G.H5 I 344 G.H5.16
Polar TM2 T 70 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 70 2x39 G.H5 C 351 G.H5.23
Polar TM6 K 237 6x25 G.S5 S 264 G.S5.01
Hydrophobic TM6 K 237 6x25 G.H5 A 345 G.H5.17
Polar TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 227 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 227 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 248 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 248 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 231 5x69 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 231 5x69 G.H5 I 344 G.H5.16
Polar TM6 K 237 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 237 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 237 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 231 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL2 S 140 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 S 140 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 137 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 137 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 244 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 244 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 137 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 348 G.H5.20
Polar TM6 S 238 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 238 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 S 140 - G.H5 I 344 G.H5.16
Polar TM6 K 237 6x25 G.h4s6 N 316 G.h4s6.10
Hydrophobic TM6 K 237 6x25 G.h4s6 N 316 G.h4s6.10
Van-der-waals TM6 K 237 6x25 G.h4s6 N 316 G.h4s6.10
Hydrophobic TM6 T 245 6x33 G.H5 L 353 G.H5.25
Polar ICL2 R 141 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 141 - G.H5 N 347 G.H5.19
Hydrophobic TM6 S 235 6x23 G.S6 Y 320 G.S6.02
Polar ICL2 S 140 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 140 - G.H5 N 347 G.H5.19