GPCRdb

(-)-noradrenaline

SMILES	NC[C@H](O)c1ccc(O)c(O)c1
InChIKey	SFLSHLFXELFNJZ-QMMMGPOBSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	2
Molecular weight (Da)	169.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7EJ0
Ligand site mutations	α_1A α_1B α_2A α_2B β₂ β₃ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	4.80	5.60	6.40	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	6.35	6.35	6.35	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.55	6.55	6.55	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.82	5.82	5.82	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	3.80	5.00	6.20	Guide to Pharmacology
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	6.58	6.58	6.58	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	4.69	4.69	4.69	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.33	8.33	8.33	Drug Central
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.50	6.45	7.40	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	6.30	6.30	6.30	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.37	6.37	6.37	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	3.60	5.50	7.40	Guide to Pharmacology
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	5.24	5.24	5.24	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.24	6.21	7.18	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central

Showing 1 to 20 of 57 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	5.50	7.05	8.60	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pEC50	5.93	5.93	5.93	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	5.66	7.25	8.04	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	5.90	7.55	9.20	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pEC50	4.99	4.99	4.99	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pEC50	6.60	7.20	7.80	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	6.57	6.57	6.57	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.60	6.60	6.60	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	6.43	6.75	7.52	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	7.35	7.35	7.35	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.80	7.80	7.80	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	7.21	7.21	7.21	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.50	7.55	8.60	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	6.02	7.00	6.60	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	6.10	6.10	6.10	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pEC50	7.90	7.90	7.90	Guide to Pharmacology
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pEC50	5.00	6.33	7.52	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	6.40	6.40	6.40	Guide to Pharmacology
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pEC50	4.52	5.59	6.67	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.03	5.03	5.03	ChEMBL

Showing 1 to 20 of 25 entries

(-)-noradrenaline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 9

Phase II 18

Phase III 27

Approved Yes

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7EJ0
Ligand site mutations	α_1A α_1B α_2A α_2B β₂ β₃ D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute poliomyelitis	1C81		0.462	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Dermatoses due to ionizing radiation, unspecified	EJ7Z		0.046	1	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hypotension, unspecified	BA2Z		0.603	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z		0.074	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Orthostatic hypotension	BA21		0.583	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified hypotension	BA2Y		0.462	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis with septic shock	1G41		0.590	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis without septic shock	1G40		0.593	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Shock, unspecified	MG40.Z		0.573	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute poliomyelitis	1C81		0.462	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Dermatoses due to ionizing radiation, unspecified	EJ7Z		0.046	1	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hypotension, unspecified	BA2Z		0.603	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z		0.074	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Orthostatic hypotension	BA21		0.583	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified hypotension	BA2Y		0.462	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis with septic shock	1G41		0.590	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis without septic shock	1G40		0.597	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Shock, unspecified	MG40.Z		0.573	3	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute poliomyelitis	1C81		0.462	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Dermatoses due to ionizing radiation, unspecified	EJ7Z		0.046	1	Yes

Showing 1 to 20 of 81 entries

This ligand is endogenous.

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(-)-noradrenaline

(-)-noradrenaline

Chemical Properties

Database connections

Bioactivities

(-)-noradrenaline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information