GPCRdb

tyramine

tyramine

SMILES	NCCc1ccc(O)cc1
InChIKey	DZGWFCGJZKJUFP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	137.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKd	5.10	5.10	5.10	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pKd	7.70	7.70	7.70	Guide to Pharmacology
TA₁	TAAR1	Rat	Trace amine	A	pKi	7.20	7.20	7.20	Guide to Pharmacology
TA₁	TAAR1	Mouse	Trace amine	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
TA₁	TAAR1	Human	Trace amine	A	pKi	7.47	7.47	7.47	PDSP Ki database

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.30	7.30	7.30	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.80	6.25	6.70	Guide to Pharmacology
TA₁	TAAR1	Rat	Trace amine	A	pEC50	6.90	7.05	7.20	Guide to Pharmacology
TA₁	TAAR1	Mouse	Trace amine	A	pEC50	6.20	6.65	7.10	Guide to Pharmacology
TA₁	TAAR1	Rat	Trace amine	A	pEC50	7.16	7.34	7.52	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	6.00	6.50	7.12	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pIC50	6.05	6.05	6.05	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	8.15	8.15	8.15	Drug Central
TA₁	TAAR1	Rat	Trace amine	A	pEC50	8.14	8.14	8.14	Drug Central
TA₁	TAAR1	Mouse	Trace amine	A	pEC50	8.15	8.15	8.15	Drug Central
TA₁	TAAR1	Mouse	Trace amine	A	pEC50	6.55	6.55	6.55	ChEMBL

Showing 1 to 11 of 11 entries

tyramine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₂

Compound is not listed as a drug.

This ligand is endogenous.