carbachol


SMILES NC(=O)OCC[N+](C)(C)C
InChIKey VPJXQGSRWJZDOB-UHFFFAOYSA-O

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 147.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 3.2 4.25 5.3 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 4.2 4.95 5.7 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 4.3 4.6 4.9 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 4.9 4.9 4.9 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.7 5.7 5.7 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 3.9 3.9 3.9 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 4.2 4.2 4.2 Guide to Pharmacology
M1 ACM1 Mouse Acetylcholine (muscarinic) A pKi 6.13 7.09 7.7 ChEMBL
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 5.58 5.58 5.58 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 4.86 5.4 6.16 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.3 6.76 8.4 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 5.24 6.35 7.51 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 4.16 4.55 5.37 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.12 5.7 7.62 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 4.29 4.58 5.2 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.39 6.43 7.7 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 4.2 4.88 6.77 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 4.0 4.2 4.4 Guide to Pharmacology
M2 ACM2 Mouse Acetylcholine (muscarinic) A pKi 4.18 6.14 8.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M3 ACM3 Mouse Acetylcholine (muscarinic) A pEC50 5.0 5.0 5.0 ChEMBL
M1 ACM1 Mouse Acetylcholine (muscarinic) A pEC50 4.4 4.4 4.4 ChEMBL
M4 ACM4 Rat Acetylcholine (muscarinic) A pIC50 6.64 6.64 6.64 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pEC50 4.92 6.99 8.37 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pIC50 4.72 6.15 7.47 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pIC50 4.35 5.69 7.64 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pEC50 6.19 6.19 6.19 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pEC50 5.05 5.65 6.44 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 4.6 4.6 4.6 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pEC50 4.22 5.99 7.35 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.14 6.96 9.4 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 5.04 5.55 6.06 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pEC50 4.82 6.08 7.66 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pEC50 4.21 6.23 7.13 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.46 6.75 8.42 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pEC50 4.47 5.34 6.6 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.0 5.58 6.34 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL