MT2 receptor (mtr1b_human)
FAMILY
Class A (Rhodopsin) Melatonin receptors Melatonin MT2 receptor
GENE
MTNR1B
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Melatonin receptor type 1B, Mel-1B-R, Mel1b receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
E
|
N
|
G
|
S
|
F
|
A
|
N
|
C
|
10 |
C
|
E
|
A
|
G
|
G
|
W
|
A
|
V
|
R
|
P
|
20 |
G
|
W
|
S
|
G
|
A
|
G
|
S
|
A
|
R
|
P
|
30 |
TM1 | |||||||||
S
|
R
|
T
|
P
|
R
|
P
|
P
|
W
|
V
|
A
|
40 |
P
|
A
|
L
|
S
|
A
|
V
|
L
|
I
|
V
|
T
|
50 |
T
|
A
|
V
|
D
|
V
|
V
|
G
|
N
|
L
|
L
|
60 |
V
|
I
|
L
|
S
|
V
|
L
|
R
|
N
|
R
|
K
|
70 |
ICL1 | TM2 | ||||||||
L
|
R
|
N
|
A
|
G
|
N
|
L
|
F
|
L
|
V
|
80 |
S
|
L
|
A
|
L
|
A
|
D
|
L
|
V
|
V
|
A
|
90 |
F
|
Y
|
P
|
Y
|
P
|
L
|
I
|
L
|
V
|
A
|
100 |
ECL1 | |||||||||
I
|
F
|
Y
|
D
|
G
|
W
|
A
|
L
|
G
|
E
|
110 |
TM3 | |||||||||
E
|
H
|
C
|
K
|
A
|
S
|
A
|
F
|
V
|
M
|
120 |
G
|
L
|
S
|
V
|
I
|
G
|
S
|
V
|
F
|
N
|
130 |
I
|
T
|
A
|
I
|
A
|
I
|
N
|
R
|
Y
|
C
|
140 |
ICL2 | |||||||||
Y
|
I
|
C
|
H
|
S
|
M
|
A
|
Y
|
H
|
R
|
150 |
TM4 | |||||||||
I
|
Y
|
R
|
R
|
W
|
H
|
T
|
P
|
L
|
H
|
160 |
I
|
C
|
L
|
I
|
W
|
L
|
L
|
T
|
V
|
V
|
170 |
A
|
L
|
L
|
P
|
N
|
F
|
F
|
V
|
G
|
S
|
180 |
ECL2 | |||||||||
L
|
E
|
Y
|
D
|
P
|
R
|
I
|
Y
|
S
|
C
|
190 |
TM5 | |||||||||
T
|
F
|
I
|
Q
|
T
|
A
|
S
|
T
|
Q
|
Y
|
200 |
T
|
A
|
A
|
V
|
V
|
V
|
I
|
H
|
F
|
L
|
210 |
L
|
P
|
I
|
A
|
V
|
V
|
S
|
F
|
C
|
Y
|
220 |
L
|
R
|
I
|
W
|
V
|
L
|
V
|
L
|
Q
|
A
|
230 |
ICL3 | |||||||||
R
|
R
|
K
|
A
|
K
|
P
|
E
|
S
|
R
|
L
|
240 |
TM6 | |||||||||
C
|
L
|
K
|
P
|
S
|
D
|
L
|
R
|
S
|
F
|
250 |
L
|
T
|
M
|
F
|
V
|
V
|
F
|
V
|
I
|
F
|
260 |
A
|
I
|
C
|
W
|
A
|
P
|
L
|
N
|
C
|
I
|
270 |
G
|
L
|
A
|
V
|
A
|
I
|
N
|
P
|
Q
|
E
|
280 |
ECL3 | TM7 | ||||||||
M
|
A
|
P
|
Q
|
I
|
P
|
E
|
G
|
L
|
F
|
290 |
V
|
T
|
S
|
Y
|
L
|
L
|
A
|
Y
|
F
|
N
|
300 |
S
|
C
|
L
|
N
|
A
|
I
|
V
|
Y
|
G
|
L
|
310 |
H8 | |||||||||
L
|
N
|
Q
|
N
|
F
|
R
|
R
|
E
|
Y
|
K
|
320 |
R
|
I
|
L
|
L
|
A
|
L
|
W
|
N
|
P
|
R
|
330 |
C-term | |||||||||
H
|
C
|
I
|
Q
|
D
|
A
|
S
|
K
|
G
|
S
|
340 |
H
|
A
|
E
|
G
|
L
|
Q
|
S
|
P
|
A
|
P
|
350 |
P
|
I
|
I
|
G
|
V
|
Q
|
H
|
Q
|
A
|
D
|
360 |
A
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
melatonin