MT2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7VH0

RESOLUTION

3.5 Å

REFERENCE

10.1038/S41467-022-28111-3

PUBLICATION DATE

March 2, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

24 interactions (Click to see)

LIGANDS

ramelteon - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

ENDOGENOUS LIGANDS

melatonin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 T 252 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 150 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 K 233 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 142 - G.H5 L 348 G.H5.20
Van-der-waals ICL2 I 142 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 154 - G.HN R 24 G.HN.48
Van-der-waals ICL2 R 154 - G.HN R 24 G.HN.48
Polar ICL3 T 252 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 T 252 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 N 312 - G.H5 G 352 G.H5.24
Hydrophobic TM5 K 235 5x73 G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 K 235 5x73 G.S6 I 319 G.S6.01
Hydrophobic TM5 A 234 5x72 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 I 142 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 I 142 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 142 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 142 - G.H5 C 351 G.H5.23
Hydrophobic TM5 R 231 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 231 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Polar TM3 Y 141 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 141 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 Y 141 3x53 G.H5 D 350 G.H5.22
Hydrophobic ICL3 M 253 - G.H5 L 348 G.H5.20
Polar ICL2 H 149 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 149 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 A 234 5x72 G.H5 A 338 G.H5.10
Hydrophobic ICL3 M 253 - G.H5 L 353 G.H5.25
Polar TM3 Y 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 A 234 5x72 G.H5 D 337 G.H5.09
Ionic TM5 K 235 5x73 G.h4s6 E 318 G.h4s6.12
Polar TM5 K 235 5x73 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 K 235 5x73 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 A 234 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM3 Y 141 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 141 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 227 5x65 G.H5 I 344 G.H5.16
Ionic TM5 R 231 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 231 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 231 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 231 5x69 G.H5 D 341 G.H5.13