PDB
7VH0
Resolution
3.5 Å
Released
March 2, 2022
Receptor
MT2
Class
A
Species
Homo sapiens
Ligand
ramelteon
Function
Agonist
Reference
10.1038/S41467-022-28111-3

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Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon M120 3.32x32 TM3 hydrophobic
ramelteon I125 3.37x37 TM3 hydrophobic
ramelteon L172 4.57x57 TM4 hydrophobic
ramelteon F192 45.52x52 ECL2 hydrophobic
ramelteon V204 5.42x43 TM5 hydrophobic
ramelteon L267 6.51x51 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
Helix box plot — Download: PNG | SVG L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7

GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x32 3.32x32 M120
3x37 3.37x37 I125
TM4
4x57 4.57x57 L172
ECL2
45x52 45.52x52 F192
TM5
5x43 5.42x43 V204
TM6
6x51 6.51x51 L267