Structure information

MT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VH0

SPECIES

Homo sapiens

RESOLUTION

3.460

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-022-28111-3

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon M120 3.32x32 TM3 hydrophobic
ramelteon I125 3.37x37 TM3 hydrophobic
ramelteon L172 4.57x57 TM4 hydrophobic
ramelteon F192 45.52x52 ECL2 hydrophobic
ramelteon V204 5.42x43 TM5 hydrophobic
ramelteon L267 6.51x51 TM6 hydrophobic

Ligands

ramelteon

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Residue Diagrams

L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7
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ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x32 3.32x32 M120
3x37 3.37x37 I125
TM4
4x57 4.57x57 L172
ECL2
45x52 45.52x52 F192
TM5
5x43 5.42x43 V204
TM6
6x51 6.51x51 L267