GPR151 (gp151_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR151
GENE
GPR151 (GALR4, GALRL, PGR7)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 151, G-protein coupled receptor PGR7, GPCR-2037, Galanin receptor 4, Galanin-receptor-like protein, GalRL
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
A
|
A
|
A
|
F
|
A
|
D
|
S
|
N
|
10 |
S
|
S
|
S
|
M
|
N
|
V
|
S
|
F
|
A
|
H
|
20 |
L
|
H
|
F
|
A
|
G
|
G
|
Y
|
L
|
P
|
S
|
30 |
TM1 | |||||||||
D
|
S
|
Q
|
D
|
W
|
R
|
T
|
I
|
I
|
P
|
40 |
A
|
L
|
L
|
V
|
A
|
V
|
C
|
L
|
V
|
G
|
50 |
F
|
V
|
G
|
N
|
L
|
C
|
V
|
I
|
G
|
I
|
60 |
ICL1 | |||||||||
L
|
L
|
H
|
N
|
A
|
W
|
K
|
G
|
K
|
P
|
70 |
TM2 | |||||||||
S
|
M
|
I
|
H
|
S
|
L
|
I
|
L
|
N
|
L
|
80 |
S
|
L
|
A
|
D
|
L
|
S
|
L
|
L
|
L
|
F
|
90 |
S
|
A
|
P
|
I
|
R
|
A
|
T
|
A
|
Y
|
S
|
100 |
ECL1 | TM3 | ||||||||
K
|
S
|
V
|
W
|
D
|
L
|
G
|
W
|
F
|
V
|
110 |
C
|
K
|
S
|
S
|
D
|
W
|
F
|
I
|
H
|
T
|
120 |
C
|
M
|
A
|
A
|
K
|
S
|
L
|
T
|
I
|
V
|
130 |
V
|
V
|
A
|
K
|
V
|
C
|
F
|
M
|
Y
|
A
|
140 |
ICL2 | |||||||||
S
|
D
|
P
|
A
|
K
|
Q
|
V
|
S
|
I
|
H
|
150 |
TM4 | |||||||||
N
|
Y
|
T
|
I
|
W
|
S
|
V
|
L
|
V
|
A
|
160 |
I
|
W
|
T
|
V
|
A
|
S
|
L
|
L
|
P
|
L
|
170 |
ECL2 | |||||||||
P
|
E
|
W
|
F
|
F
|
S
|
T
|
I
|
R
|
H
|
180 |
H
|
E
|
G
|
V
|
E
|
M
|
C
|
L
|
V
|
D
|
190 |
TM5 | |||||||||
V
|
P
|
A
|
V
|
A
|
E
|
E
|
F
|
M
|
S
|
200 |
M
|
F
|
G
|
K
|
L
|
Y
|
P
|
L
|
L
|
A
|
210 |
F
|
G
|
L
|
P
|
L
|
F
|
F
|
A
|
S
|
F
|
220 |
Y
|
F
|
W
|
R
|
A
|
Y
|
D
|
Q
|
C
|
K
|
230 |
ICL3 | TM6 | ||||||||
K
|
R
|
G
|
T
|
K
|
T
|
Q
|
N
|
L
|
R
|
240 |
N
|
Q
|
I
|
R
|
S
|
K
|
Q
|
V
|
T
|
V
|
250 |
M
|
L
|
L
|
S
|
I
|
A
|
I
|
I
|
S
|
A
|
260 |
L
|
L
|
W
|
L
|
P
|
E
|
W
|
V
|
A
|
W
|
270 |
ECL3 | |||||||||
L
|
W
|
V
|
W
|
H
|
L
|
K
|
A
|
A
|
G
|
280 |
TM7 | |||||||||
P
|
A
|
P
|
P
|
Q
|
G
|
F
|
I
|
A
|
L
|
290 |
S
|
Q
|
V
|
L
|
M
|
F
|
S
|
I
|
S
|
S
|
300 |
A
|
N
|
P
|
L
|
I
|
F
|
L
|
V
|
M
|
S
|
310 |
H8 | |||||||||
E
|
E
|
F
|
R
|
E
|
G
|
L
|
K
|
G
|
V
|
320 |
C-term | |||||||||
W
|
K
|
W
|
M
|
I
|
T
|
K
|
K
|
P
|
P
|
330 |
T
|
V
|
S
|
E
|
S
|
Q
|
E
|
T
|
P
|
A
|
340 |
G
|
N
|
S
|
E
|
G
|
L
|
P
|
D
|
K
|
V
|
350 |
P
|
S
|
P
|
E
|
S
|
P
|
A
|
S
|
I
|
P
|
360 |
E
|
K
|
E
|
K
|
P
|
S
|
S
|
P
|
S
|
S
|
370 |
G
|
K
|
G
|
K
|
T
|
E
|
K
|
A
|
E
|
I
|
380 |
P
|
I
|
L
|
P
|
D
|
V
|
E
|
Q
|
F
|
W
|
390 |
H
|
E
|
R
|
D
|
T
|
V
|
P
|
S
|
V
|
Q
|
400 |
D
|
N
|
D
|
P
|
I
|
P
|
W
|
E
|
H
|
E
|
410 |
D
|
Q
|
E
|
T
|
G
|
E
|
G
|
V
|
K
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available