PrRP receptor (prlhr_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Prolactin-releasing peptide receptors PrRP receptor
GENE
PRLHR (GPR10, GR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prolactin-releasing peptide receptor, PrRP receptor, PrRPR, G-protein coupled receptor 10, hGR3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
S
|
T
|
T
|
R
|
G
|
P
|
R
|
10 |
V
|
S
|
D
|
L
|
F
|
S
|
G
|
L
|
P
|
P
|
20 |
A
|
V
|
T
|
T
|
P
|
A
|
N
|
Q
|
S
|
A
|
30 |
E
|
A
|
S
|
A
|
G
|
N
|
G
|
S
|
V
|
A
|
40 |
G
|
A
|
D
|
A
|
P
|
A
|
V
|
T
|
P
|
F
|
50 |
TM1 | |||||||||
Q
|
S
|
L
|
Q
|
L
|
V
|
H
|
Q
|
L
|
K
|
60 |
G
|
L
|
I
|
V
|
L
|
L
|
Y
|
S
|
V
|
V
|
70 |
V
|
V
|
V
|
G
|
L
|
V
|
G
|
N
|
C
|
L
|
80 |
L
|
V
|
L
|
V
|
I
|
A
|
R
|
V
|
R
|
R
|
90 |
ICL1 | TM2 | ||||||||
L
|
H
|
N
|
V
|
T
|
N
|
F
|
L
|
I
|
G
|
100 |
N
|
L
|
A
|
L
|
S
|
D
|
V
|
L
|
M
|
C
|
110 |
T
|
A
|
C
|
V
|
P
|
L
|
T
|
L
|
A
|
Y
|
120 |
ECL1 | |||||||||
A
|
F
|
E
|
P
|
R
|
G
|
W
|
V
|
F
|
G
|
130 |
TM3 | |||||||||
G
|
G
|
L
|
C
|
H
|
L
|
V
|
F
|
F
|
L
|
140 |
Q
|
P
|
V
|
T
|
V
|
Y
|
V
|
S
|
V
|
F
|
150 |
T
|
L
|
T
|
T
|
I
|
A
|
V
|
D
|
R
|
Y
|
160 |
ICL2 | |||||||||
V
|
V
|
L
|
V
|
H
|
P
|
L
|
R
|
R
|
R
|
170 |
TM4 | |||||||||
I
|
S
|
L
|
R
|
L
|
S
|
A
|
Y
|
A
|
V
|
180 |
L
|
A
|
I
|
W
|
A
|
L
|
S
|
A
|
V
|
L
|
190 |
A
|
L
|
P
|
A
|
A
|
V
|
H
|
T
|
Y
|
H
|
200 |
ECL2 | |||||||||
V
|
E
|
L
|
K
|
P
|
H
|
D
|
V
|
R
|
L
|
210 |
C
|
E
|
E
|
F
|
W
|
G
|
S
|
Q
|
E
|
R
|
220 |
TM5 | |||||||||
Q
|
R
|
Q
|
L
|
Y
|
A
|
W
|
G
|
L
|
L
|
230 |
L
|
V
|
T
|
Y
|
L
|
L
|
P
|
L
|
L
|
V
|
240 |
I
|
L
|
L
|
S
|
Y
|
V
|
R
|
V
|
S
|
V
|
250 |
K
|
L
|
R
|
N
|
R
|
V
|
V
|
P
|
G
|
C
|
260 |
ICL3 | TM6 | ||||||||
V
|
T
|
Q
|
S
|
Q
|
A
|
D
|
W
|
D
|
R
|
270 |
A
|
R
|
R
|
R
|
R
|
T
|
F
|
C
|
L
|
L
|
280 |
V
|
V
|
I
|
V
|
V
|
V
|
F
|
A
|
V
|
C
|
290 |
W
|
L
|
P
|
L
|
H
|
V
|
F
|
N
|
L
|
L
|
300 |
ECL3 | |||||||||
R
|
D
|
L
|
D
|
P
|
H
|
A
|
I
|
D
|
P
|
310 |
TM7 | |||||||||
Y
|
A
|
F
|
G
|
L
|
V
|
Q
|
L
|
L
|
C
|
320 |
H
|
W
|
L
|
A
|
M
|
S
|
S
|
A
|
C
|
Y
|
330 |
H8 | |||||||||
N
|
P
|
F
|
I
|
Y
|
A
|
W
|
L
|
H
|
D
|
340 |
S
|
F
|
R
|
E
|
E
|
L
|
R
|
K
|
L
|
L
|
350 |
V
|
A
|
W
|
P
|
R
|
K
|
I
|
A
|
P
|
H
|
360 |
C-term | |||||||||
G
|
Q
|
N
|
M
|
T
|
V
|
S
|
V
|
V
|
I
|
370 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PrRP-20, neuropeptide Y, PrRP-31, PTHrP
STRUCTURE MODELS
STRUCTURES
No structures available