GPR132 (gp132_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR132
GENE
GPR132 (G2A)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 132, G2 accumulation protein
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
C
|
P
|
M
|
L
|
L
|
K
|
N
|
G
|
Y
|
10 |
N
|
G
|
N
|
A
|
T
|
P
|
V
|
T
|
T
|
T
|
20 |
A
|
P
|
W
|
A
|
S
|
L
|
G
|
L
|
S
|
A
|
30 |
TM1 | |||||||||
K
|
T
|
C
|
N
|
N
|
V
|
S
|
F
|
E
|
E
|
40 |
S
|
R
|
I
|
V
|
L
|
V
|
V
|
V
|
Y
|
S
|
50 |
A
|
V
|
C
|
T
|
L
|
G
|
V
|
P
|
A
|
N
|
60 |
C
|
L
|
T
|
A
|
W
|
L
|
A
|
L
|
L
|
Q
|
70 |
ICL1 | TM2 | ||||||||
V
|
L
|
Q
|
G
|
N
|
V
|
L
|
A
|
V
|
Y
|
80 |
L
|
L
|
C
|
L
|
A
|
L
|
C
|
E
|
L
|
L
|
90 |
Y
|
T
|
G
|
T
|
L
|
P
|
L
|
W
|
V
|
I
|
100 |
ECL1 | |||||||||
Y
|
I
|
R
|
N
|
Q
|
H
|
R
|
W
|
T
|
L
|
110 |
TM3 | |||||||||
G
|
L
|
L
|
A
|
C
|
K
|
V
|
T
|
A
|
Y
|
120 |
I
|
F
|
F
|
C
|
N
|
I
|
Y
|
V
|
S
|
I
|
130 |
L
|
F
|
L
|
C
|
C
|
I
|
S
|
C
|
D
|
R
|
140 |
ICL2 | |||||||||
F
|
V
|
A
|
V
|
V
|
Y
|
A
|
L
|
E
|
S
|
150 |
TM4 | |||||||||
R
|
G
|
R
|
R
|
R
|
R
|
R
|
T
|
A
|
I
|
160 |
L
|
I
|
S
|
A
|
C
|
I
|
F
|
I
|
L
|
V
|
170 |
G
|
I
|
V
|
H
|
Y
|
P
|
V
|
F
|
Q
|
T
|
180 |
ECL2 | |||||||||
E
|
D
|
K
|
E
|
T
|
C
|
F
|
D
|
M
|
L
|
190 |
TM5 | |||||||||
Q
|
M
|
D
|
S
|
R
|
I
|
A
|
G
|
Y
|
Y
|
200 |
Y
|
A
|
R
|
F
|
T
|
V
|
G
|
F
|
A
|
I
|
210 |
P
|
L
|
S
|
I
|
I
|
A
|
F
|
T
|
N
|
H
|
220 |
R
|
I
|
F
|
R
|
S
|
I
|
K
|
Q
|
S
|
M
|
230 |
ICL3 | TM6 | ||||||||
G
|
L
|
S
|
A
|
A
|
Q
|
K
|
A
|
K
|
V
|
240 |
K
|
H
|
S
|
A
|
I
|
A
|
V
|
V
|
V
|
I
|
250 |
F
|
L
|
V
|
C
|
F
|
A
|
P
|
Y
|
H
|
L
|
260 |
V
|
L
|
L
|
V
|
K
|
A
|
A
|
A
|
F
|
S
|
270 |
ECL3 | TM7 | ||||||||
Y
|
Y
|
R
|
G
|
D
|
R
|
N
|
A
|
M
|
C
|
280 |
G
|
L
|
E
|
E
|
R
|
L
|
Y
|
T
|
A
|
S
|
290 |
V
|
V
|
F
|
L
|
C
|
L
|
S
|
T
|
V
|
N
|
300 |
G
|
V
|
A
|
D
|
P
|
I
|
I
|
Y
|
V
|
L
|
310 |
H8 | |||||||||
A
|
T
|
D
|
H
|
S
|
R
|
Q
|
E
|
V
|
S
|
320 |
R
|
I
|
H
|
K
|
G
|
W
|
K
|
E
|
W
|
S
|
330 |
C-term | |||||||||
M
|
K
|
T
|
D
|
V
|
T
|
R
|
L
|
T
|
H
|
340 |
S
|
R
|
D
|
T
|
E
|
E
|
L
|
Q
|
S
|
P
|
350 |
V
|
A
|
L
|
A
|
D
|
H
|
Y
|
T
|
F
|
S
|
360 |
R
|
P
|
V
|
H
|
P
|
P
|
G
|
S
|
P
|
C
|
370 |
P
|
A
|
K
|
R
|
L
|
I
|
E
|
E
|
S
|
C
|
380 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
9-hydroxyoctadecadienoic acid
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page