GPR132 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HQM

RESOLUTION

3.0 Å

REFERENCE

10.1038/S42255-023-00899-4

PUBLICATION DATE

Oct. 11, 2023

3D VIEW

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LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

CHEMBL3354065 - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

9-hydroxyoctadecadienoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL2 R 151 34x54 G.S3 L 194 G.S3.01
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 L 77 2x39 G.H5 C 351 G.H5.23
Ionic TM4 R 155 4x38 G.HN E 28 G.HN.52
Polar TM4 R 155 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 155 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Hydrophobic H8 T 312 8x47 G.H5 L 353 G.H5.25
Polar ICL2 R 151 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 151 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 151 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 153 34x56 G.hns1 R 32 G.hns1.03
Polar ICL3 G 231 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 231 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 G 231 - G.H5 D 341 G.H5.13
Hydrophobic TM5 I 226 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 S 229 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 147 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 147 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 148 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 148 34x51 G.S3 L 194 G.S3.01
Polar H8 H 314 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 H 314 8x49 G.H5 K 349 G.H5.21
Polar TM6 K 239 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 239 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 239 6x32 G.H5 L 353 G.H5.25
Polar H8 H 314 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 H 314 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 H 314 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 T 312 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 T 312 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 H 314 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 144 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 144 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 I 344 G.H5.16
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 L 77 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 L 77 2x39 G.H5 D 350 G.H5.22
Polar H8 D 313 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 240 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 243 6x36 G.H5 L 353 G.H5.25