M2 receptor (acm2_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Acetylcholine receptors (muscarinic) M2 receptor
GENE
CHRM2
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Muscarinic acetylcholine receptor M2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
N
|
S
|
T
|
N
|
S
|
S
|
N
|
N
|
10 |
S
|
L
|
A
|
L
|
T
|
S
|
P
|
Y
|
K
|
T
|
20 |
TM1 | |||||||||
F
|
E
|
V
|
V
|
F
|
I
|
V
|
L
|
V
|
A
|
30 |
G
|
S
|
L
|
S
|
L
|
V
|
T
|
I
|
I
|
G
|
40 |
N
|
I
|
L
|
V
|
M
|
V
|
S
|
I
|
K
|
V
|
50 |
ICL1 | TM2 | ||||||||
N
|
R
|
H
|
L
|
Q
|
T
|
V
|
N
|
N
|
Y
|
60 |
F
|
L
|
F
|
S
|
L
|
A
|
C
|
A
|
D
|
L
|
70 |
I
|
I
|
G
|
V
|
F
|
S
|
M
|
N
|
L
|
Y
|
80 |
T
|
L
|
Y
|
T
|
V
|
I
|
G
|
Y
|
W
|
P
|
90 |
ECL1 | TM3 | ||||||||
L
|
G
|
P
|
V
|
V
|
C
|
D
|
L
|
W
|
L
|
100 |
A
|
L
|
D
|
Y
|
V
|
V
|
S
|
N
|
A
|
S
|
110 |
V
|
M
|
N
|
L
|
L
|
I
|
I
|
S
|
F
|
D
|
120 |
R
|
Y
|
F
|
C
|
V
|
T
|
K
|
P
|
L
|
T
|
130 |
ICL2 | TM4 | ||||||||
Y
|
P
|
V
|
K
|
R
|
T
|
T
|
K
|
M
|
A
|
140 |
G
|
M
|
M
|
I
|
A
|
A
|
A
|
W
|
V
|
L
|
150 |
S
|
F
|
I
|
L
|
W
|
A
|
P
|
A
|
I
|
L
|
160 |
F
|
W
|
Q
|
F
|
I
|
V
|
G
|
V
|
R
|
T
|
170 |
ECL2 | |||||||||
V
|
E
|
D
|
G
|
E
|
C
|
Y
|
I
|
Q
|
F
|
180 |
TM5 | |||||||||
F
|
S
|
N
|
A
|
A
|
V
|
T
|
F
|
G
|
T
|
190 |
A
|
I
|
A
|
A
|
F
|
Y
|
L
|
P
|
V
|
I
|
200 |
I
|
M
|
T
|
V
|
L
|
Y
|
W
|
H
|
I
|
S
|
210 |
R
|
A
|
S
|
K
|
S
|
R
|
I
|
K
|
K
|
D
|
220 |
ICL3 | |||||||||
K
|
K
|
E
|
P
|
V
|
A
|
N
|
Q
|
D
|
P
|
230 |
V
|
S
|
P
|
S
|
L
|
V
|
Q
|
G
|
R
|
I
|
240 |
V
|
K
|
P
|
N
|
N
|
N
|
N
|
M
|
P
|
S
|
250 |
S
|
D
|
D
|
G
|
L
|
E
|
H
|
N
|
K
|
I
|
260 |
Q
|
N
|
G
|
K
|
A
|
P
|
R
|
D
|
P
|
V
|
270 |
T
|
E
|
N
|
C
|
V
|
Q
|
G
|
E
|
E
|
K
|
280 |
E
|
S
|
S
|
N
|
D
|
S
|
T
|
S
|
V
|
S
|
290 |
A
|
V
|
A
|
S
|
N
|
M
|
R
|
D
|
D
|
E
|
300 |
I
|
T
|
Q
|
D
|
E
|
N
|
T
|
V
|
S
|
T
|
310 |
S
|
L
|
G
|
H
|
S
|
K
|
D
|
E
|
N
|
S
|
320 |
K
|
Q
|
T
|
C
|
I
|
R
|
I
|
G
|
T
|
K
|
330 |
T
|
P
|
K
|
S
|
D
|
S
|
C
|
T
|
P
|
T
|
340 |
N
|
T
|
T
|
V
|
E
|
V
|
V
|
G
|
S
|
S
|
350 |
G
|
Q
|
N
|
G
|
D
|
E
|
K
|
Q
|
N
|
I
|
360 |
V
|
A
|
R
|
K
|
I
|
V
|
K
|
M
|
T
|
K
|
370 |
TM6 | |||||||||
Q
|
P
|
A
|
K
|
K
|
K
|
P
|
P
|
P
|
S
|
380 |
R
|
E
|
K
|
K
|
V
|
T
|
R
|
T
|
I
|
L
|
390 |
A
|
I
|
L
|
L
|
A
|
F
|
I
|
I
|
T
|
W
|
400 |
A
|
P
|
Y
|
N
|
V
|
M
|
V
|
L
|
I
|
N
|
410 |
ECL3 | TM7 | ||||||||
T
|
F
|
C
|
A
|
P
|
C
|
I
|
P
|
N
|
T
|
420 |
V
|
W
|
T
|
I
|
G
|
Y
|
W
|
L
|
C
|
Y
|
430 |
I
|
N
|
S
|
T
|
I
|
N
|
P
|
A
|
C
|
Y
|
440 |
H8 | |||||||||
A
|
L
|
C
|
N
|
A
|
T
|
F
|
K
|
K
|
T
|
450 |
F
|
K
|
H
|
L
|
L
|
M
|
C
|
H
|
Y
|
K
|
460 |
C-term | |||||
N
|
I
|
G
|
A
|
T
|
R
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
acetylcholine