M2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Jan. 25, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
N19C23L25G.H5GproteinT6x36C3x53R3x50GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H5GPCR segments:TM3TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x533x545x585x616x296x326x336x366x37G.H5.26G.H5.25G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.S6.02G.S3.01G.hns1.03G.hns1.02G.HN.52G.HN.51Res. Pos.M2 (7T94)- (7T94)-----------RCVYIRKVTIRCVYIRKVTIICLNLDIAYIGILYAK

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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