M2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7T94

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Jan. 25, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

17 interactions (Click to see)

LIGANDS

LY2119620 - PAM pubchem gtoplig chembl_ligand ,

acetylcholine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central gtoplig

ENDOGENOUS LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 128 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 128 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 128 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 133 - G.HN I 28 G.HN.52
Aromatic TM6 K 384 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 T 130 - G.hns1 K 32 G.hns1.03
Hydrophobic TM6 V 385 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 385 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 385 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 385 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 V 385 6x33 G.H5 Y 354 G.H5.26
Polar TM6 T 388 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 T 388 6x36 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 I 217 - G.H5 D 341 G.H5.13
Hydrophobic TM6 R 381 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM5 Y 206 5x58 G.H5 L 353 G.H5.25
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 389 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 389 6x37 G.H5 L 353 G.H5.25
Ionic TM6 R 381 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 381 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 381 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 381 6x29 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 128 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 129 - G.S3 L 195 G.S3.01
Hydrophobic ICL3 S 213 - G.H5 L 348 G.H5.20
Hydrophobic TM6 R 381 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 381 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 V 133 - G.HN G 27 G.HN.51
Hydrophobic TM6 R 381 6x29 G.H5 A 345 G.H5.17
Van-der-waals TM6 R 381 6x29 G.H5 A 345 G.H5.17
Hydrophobic ICL3 I 217 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 I 217 - G.S6 Y 320 G.S6.02
Polar TM3 C 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 124 3x53 G.H5 N 347 G.H5.19
Polar TM6 T 388 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 134 - G.HN I 28 G.HN.52
Hydrophobic TM5 I 209 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 133 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 133 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 121 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 129 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 129 - G.H5 I 343 G.H5.15