M2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Jan. 25, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
I 217 - ICL3 D 341 G.H5.13 hydrophobic
I 217 - ICL3 D 341 G.H5.13 van-der-waals
V 125 3x54 TM3 L 348 G.H5.20 hydrophobic
R 381 6x29 TM6 L 348 G.H5.20 hydrophobic
N 444 8x47 H8 G 350 G.H5.22 polar
I 389 6x37 TM6 L 353 G.H5.25 hydrophobic
I 209 5x61 TM5 L 353 G.H5.25 hydrophobic
I 209 5x61 TM5 L 353 G.H5.25 van-der-waals
T 388 6x36 TM6 L 353 G.H5.25 polar
T 388 6x36 TM6 L 353 G.H5.25 hydrophobic
R 121 3x50 TM3 C 351 G.H5.23 polar
R 121 3x50 TM3 C 351 G.H5.23 hydrophobic
R 121 3x50 TM3 C 351 G.H5.23 van-der-waals
P 128 - ICL2 I 344 G.H5.16 hydrophobic
P 128 - ICL2 I 344 G.H5.16 van-der-waals
S 213 5x65 TM5 L 348 G.H5.20 hydrophobic
P 128 - ICL2 I 343 G.H5.15 hydrophobic
V 385 6x33 TM6 L 348 G.H5.20 hydrophobic
V 385 6x33 TM6 L 348 G.H5.20 van-der-waals
C 443 - ICL4 G 352 G.H5.24 hydrophobic
C 443 - ICL4 G 352 G.H5.24 van-der-waals
P 128 - ICL2 N 347 G.H5.19 polar
P 128 - ICL2 N 347 G.H5.19 van-der-waals
K 384 6x32 TM6 Y 354 G.H5.26 aromatic
K 384 6x32 TM6 Y 354 G.H5.26 hydrophobic
V 385 6x33 TM6 L 353 G.H5.25 hydrophobic
S 215 - ICL3 D 341 G.H5.13 polar
R 381 6x29 TM6 D 341 G.H5.13 ionic
R 381 6x29 TM6 D 341 G.H5.13 polar
C 124 3x53 TM3 N 347 G.H5.19 polar
N 444 8x47 H8 G 352 G.H5.24 hydrophobic
I 217 - ICL3 D 337 G.H5.09 hydrophobic
R 381 6x29 TM6 A 345 G.H5.17 hydrophobic
R 381 6x29 TM6 A 345 G.H5.17 van-der-waals
R 381 6x29 TM6 Y 354 G.H5.26 hydrophobic
R 381 6x29 TM6 Y 354 G.H5.26 van-der-waals
C 124 3x53 TM3 C 351 G.H5.23 hydrophobic