CRF1 receptor (crfr1_human)
FAMILY
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors CRF1 receptor
GENE
CRHR1 (CRFR, CRFR1, CRHR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Isoform CRF-R2 of Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
G
|
H
|
P
|
Q
|
L
|
R
|
L
|
V
|
10 |
K
|
A
|
L
|
L
|
L
|
L
|
G
|
L
|
N
|
P
|
20 |
V
|
S
|
A
|
S
|
L
|
Q
|
D
|
Q
|
H
|
C
|
30 |
E
|
S
|
L
|
S
|
L
|
A
|
S
|
N
|
I
|
S
|
40 |
G
|
L
|
Q
|
C
|
N
|
A
|
S
|
V
|
D
|
L
|
50 |
I
|
G
|
T
|
C
|
W
|
P
|
R
|
S
|
P
|
A
|
60 |
G
|
Q
|
L
|
V
|
V
|
R
|
P
|
C
|
P
|
A
|
70 |
F
|
F
|
Y
|
G
|
V
|
R
|
Y
|
N
|
T
|
T
|
80 |
N
|
N
|
G
|
Y
|
R
|
E
|
C
|
L
|
A
|
N
|
90 |
G
|
S
|
W
|
A
|
A
|
R
|
V
|
N
|
Y
|
S
|
100 |
TM1 | |||||||||
E
|
C
|
Q
|
E
|
I
|
L
|
N
|
E
|
E
|
K
|
110 |
K
|
S
|
K
|
V
|
H
|
Y
|
H
|
V
|
A
|
V
|
120 |
I
|
I
|
N
|
Y
|
L
|
G
|
H
|
C
|
I
|
S
|
130 |
L
|
V
|
A
|
L
|
L
|
V
|
A
|
F
|
V
|
L
|
140 |
ICL1 | |||||||||
F
|
L
|
R
|
L
|
R
|
S
|
I
|
R
|
C
|
L
|
150 |
TM2 | |||||||||
R
|
N
|
I
|
I
|
H
|
W
|
N
|
L
|
I
|
S
|
160 |
A
|
F
|
I
|
L
|
R
|
N
|
A
|
T
|
W
|
F
|
170 |
ECL1 | |||||||||
V
|
V
|
Q
|
L
|
T
|
M
|
S
|
P
|
E
|
V
|
180 |
TM3 | |||||||||
H
|
Q
|
S
|
N
|
V
|
G
|
W
|
C
|
R
|
L
|
190 |
V
|
T
|
A
|
A
|
Y
|
N
|
Y
|
F
|
H
|
V
|
200 |
T
|
N
|
F
|
F
|
W
|
M
|
F
|
G
|
E
|
G
|
210 |
C
|
Y
|
L
|
H
|
T
|
A
|
I
|
V
|
L
|
T
|
220 |
ICL2 | TM4 | ||||||||
Y
|
S
|
T
|
D
|
R
|
L
|
R
|
K
|
W
|
M
|
230 |
F
|
I
|
C
|
I
|
G
|
W
|
G
|
V
|
P
|
F
|
240 |
P
|
I
|
I
|
V
|
A
|
W
|
A
|
I
|
G
|
K
|
250 |
ECL2 | |||||||||
L
|
Y
|
Y
|
D
|
N
|
E
|
K
|
C
|
W
|
F
|
260 |
TM5 | |||||||||
G
|
K
|
R
|
P
|
G
|
V
|
Y
|
T
|
D
|
Y
|
270 |
I
|
Y
|
Q
|
G
|
P
|
M
|
I
|
L
|
V
|
L
|
280 |
L
|
I
|
N
|
F
|
I
|
F
|
L
|
F
|
N
|
I
|
290 |
V
|
R
|
I
|
L
|
M
|
T
|
K
|
L
|
R
|
A
|
300 |
ICL3 | TM6 | ||||||||
S
|
T
|
T
|
S
|
E
|
T
|
I
|
Q
|
Y
|
R
|
310 |
K
|
A
|
V
|
K
|
A
|
T
|
L
|
V
|
L
|
L
|
320 |
P
|
L
|
L
|
G
|
I
|
T
|
Y
|
M
|
L
|
F
|
330 |
ECL3 | TM7 | ||||||||
F
|
V
|
N
|
P
|
G
|
E
|
D
|
E
|
V
|
S
|
340 |
R
|
V
|
V
|
F
|
I
|
Y
|
F
|
N
|
S
|
F
|
350 |
L
|
E
|
S
|
F
|
Q
|
G
|
F
|
F
|
V
|
S
|
360 |
H8 | |||||||||
V
|
F
|
Y
|
C
|
F
|
L
|
N
|
S
|
E
|
V
|
370 |
R
|
S
|
A
|
I
|
R
|
K
|
R
|
W
|
H
|
R
|
380 |
W
|
Q
|
D
|
K
|
H
|
S
|
I
|
R
|
A
|
R
|
390 |
C-term | |||||||||
V
|
A
|
R
|
A
|
M
|
S
|
I
|
P
|
T
|
S
|
400 |
P
|
T
|
R
|
V
|
S
|
F
|
H
|
S
|
I
|
K
|
410 |
Q
|
S
|
T
|
A
|
V
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
corticotrophin-releasing hormone, urocortin 1, urocortin 2