CCR1 (ccr1_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CCR1
GENE
CCR1 (CMKBR1, CMKR1, SCYAR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
T
|
P
|
N
|
T
|
T
|
E
|
D
|
Y
|
10 |
D
|
T
|
T
|
T
|
E
|
F
|
D
|
Y
|
G
|
D
|
20 |
TM1 | |||||||||
A
|
T
|
P
|
C
|
Q
|
K
|
V
|
N
|
E
|
R
|
30 |
A
|
F
|
G
|
A
|
Q
|
L
|
L
|
P
|
P
|
L
|
40 |
Y
|
S
|
L
|
V
|
F
|
V
|
I
|
G
|
L
|
V
|
50 |
G
|
N
|
I
|
L
|
V
|
V
|
L
|
V
|
L
|
V
|
60 |
ICL1 | TM2 | ||||||||
Q
|
Y
|
K
|
R
|
L
|
K
|
N
|
M
|
T
|
S
|
70 |
I
|
Y
|
L
|
L
|
N
|
L
|
A
|
I
|
S
|
D
|
80 |
L
|
L
|
F
|
L
|
F
|
T
|
L
|
P
|
F
|
W
|
90 |
I
|
D
|
Y
|
K
|
L
|
K
|
D
|
D
|
W
|
V
|
100 |
ECL1 | TM3 | ||||||||
F
|
G
|
D
|
A
|
M
|
C
|
K
|
I
|
L
|
S
|
110 |
G
|
F
|
Y
|
Y
|
T
|
G
|
L
|
Y
|
S
|
E
|
120 |
I
|
F
|
F
|
I
|
I
|
L
|
L
|
T
|
I
|
D
|
130 |
R
|
Y
|
L
|
A
|
I
|
V
|
H
|
A
|
V
|
F
|
140 |
ICL2 | TM4 | ||||||||
A
|
L
|
R
|
A
|
R
|
T
|
V
|
T
|
F
|
G
|
150 |
V
|
I
|
T
|
S
|
I
|
I
|
I
|
W
|
A
|
L
|
160 |
A
|
I
|
L
|
A
|
S
|
M
|
P
|
G
|
L
|
Y
|
170 |
ECL2 | |||||||||
F
|
S
|
K
|
T
|
Q
|
W
|
E
|
F
|
T
|
H
|
180 |
H
|
T
|
C
|
S
|
L
|
H
|
F
|
P
|
H
|
E
|
190 |
TM5 | |||||||||
S
|
L
|
R
|
E
|
W
|
K
|
L
|
F
|
Q
|
A
|
200 |
L
|
K
|
L
|
N
|
L
|
F
|
G
|
L
|
V
|
L
|
210 |
P
|
L
|
L
|
V
|
M
|
I
|
I
|
C
|
Y
|
T
|
220 |
G
|
I
|
I
|
K
|
I
|
L
|
L
|
R
|
R
|
P
|
230 |
TM6 | |||||||||
N
|
E
|
K
|
K
|
S
|
K
|
A
|
V
|
R
|
L
|
240 |
I
|
F
|
V
|
I
|
M
|
I
|
I
|
F
|
F
|
L
|
250 |
F
|
W
|
T
|
P
|
Y
|
N
|
L
|
T
|
I
|
L
|
260 |
I
|
S
|
V
|
F
|
Q
|
D
|
F
|
L
|
F
|
T
|
270 |
ECL3 | TM7 | ||||||||
H
|
E
|
C
|
E
|
Q
|
S
|
R
|
H
|
L
|
D
|
280 |
L
|
A
|
V
|
Q
|
V
|
T
|
E
|
V
|
I
|
A
|
290 |
Y
|
T
|
H
|
C
|
C
|
V
|
N
|
P
|
V
|
I
|
300 |
H8 | |||||||||
Y
|
A
|
F
|
V
|
G
|
E
|
R
|
F
|
R
|
K
|
310 |
Y
|
L
|
R
|
Q
|
L
|
F
|
H
|
R
|
R
|
V
|
320 |
C-term | |||||||||
A
|
V
|
H
|
L
|
V
|
K
|
W
|
L
|
P
|
F
|
330 |
L
|
S
|
V
|
D
|
R
|
L
|
E
|
R
|
V
|
S
|
340 |
S
|
T
|
S
|
P
|
S
|
T
|
G
|
E
|
H
|
E
|
350 |
L
|
S
|
A
|
G
|
F
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL14, CCL15, CCL8, CCL5, CCL16, CCL4, CCL23, CCL13, CCL7, CCL3
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page