HCA2 receptor (hcar2_human)
FAMILY
Class A (Rhodopsin) Alicarboxylic acid receptors Hydroxycarboxylic acid receptors HCA2 receptor
GENE
HCAR2 (GPR109A, HCA2, HM74A, NIACR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
R
|
H
|
H
|
L
|
Q
|
D
|
H
|
F
|
10 |
L
|
E
|
I
|
D
|
K
|
K
|
N
|
C
|
C
|
V
|
20 |
TM1 | |||||||||
F
|
R
|
D
|
D
|
F
|
I
|
V
|
K
|
V
|
L
|
30 |
P
|
P
|
V
|
L
|
G
|
L
|
E
|
F
|
I
|
F
|
40 |
G
|
L
|
L
|
G
|
N
|
G
|
L
|
A
|
L
|
W
|
50 |
ICL1 | |||||||||
I
|
F
|
C
|
F
|
H
|
L
|
K
|
S
|
W
|
K
|
60 |
TM2 | |||||||||
S
|
S
|
R
|
I
|
F
|
L
|
F
|
N
|
L
|
A
|
70 |
V
|
A
|
D
|
F
|
L
|
L
|
I
|
I
|
C
|
L
|
80 |
P
|
F
|
L
|
M
|
D
|
N
|
Y
|
V
|
R
|
R
|
90 |
ECL1 | TM3 | ||||||||
W
|
D
|
W
|
K
|
F
|
G
|
D
|
I
|
P
|
C
|
100 |
R
|
L
|
M
|
L
|
F
|
M
|
L
|
A
|
M
|
N
|
110 |
R
|
Q
|
G
|
S
|
I
|
I
|
F
|
L
|
T
|
V
|
120 |
V
|
A
|
V
|
D
|
R
|
Y
|
F
|
R
|
V
|
V
|
130 |
ICL2 | |||||||||
H
|
P
|
H
|
H
|
A
|
L
|
N
|
K
|
I
|
S
|
140 |
TM4 | |||||||||
N
|
R
|
T
|
A
|
A
|
I
|
I
|
S
|
C
|
L
|
150 |
L
|
W
|
G
|
I
|
T
|
I
|
G
|
L
|
T
|
V
|
160 |
ECL2 | |||||||||
H
|
L
|
L
|
K
|
K
|
K
|
M
|
P
|
I
|
Q
|
170 |
N
|
G
|
G
|
A
|
N
|
L
|
C
|
S
|
S
|
F
|
180 |
TM5 | |||||||||
S
|
I
|
C
|
H
|
T
|
F
|
Q
|
W
|
H
|
E
|
190 |
A
|
M
|
F
|
L
|
L
|
E
|
F
|
F
|
L
|
P
|
200 |
L
|
G
|
I
|
I
|
L
|
F
|
C
|
S
|
A
|
R
|
210 |
I
|
I
|
W
|
S
|
L
|
R
|
Q
|
R
|
Q
|
M
|
220 |
ICL3 | TM6 | ||||||||
D
|
R
|
H
|
A
|
K
|
I
|
K
|
R
|
A
|
I
|
230 |
T
|
F
|
I
|
M
|
V
|
V
|
A
|
I
|
V
|
F
|
240 |
V
|
I
|
C
|
F
|
L
|
P
|
S
|
V
|
V
|
V
|
250 |
R
|
I
|
R
|
I
|
F
|
W
|
L
|
L
|
H
|
T
|
260 |
ECL3 | |||||||||
S
|
G
|
T
|
Q
|
N
|
C
|
E
|
V
|
Y
|
R
|
270 |
TM7 | |||||||||
S
|
V
|
D
|
L
|
A
|
F
|
F
|
I
|
T
|
L
|
280 |
S
|
F
|
T
|
Y
|
M
|
N
|
S
|
M
|
L
|
D
|
290 |
H8 | |||||||||
P
|
V
|
V
|
Y
|
Y
|
F
|
S
|
S
|
P
|
S
|
300 |
F
|
P
|
N
|
F
|
F
|
S
|
T
|
L
|
I
|
N
|
310 |
C-term | |||||||||
R
|
C
|
L
|
Q
|
R
|
K
|
M
|
T
|
G
|
E
|
320 |
P
|
D
|
N
|
N
|
R
|
S
|
T
|
S
|
V
|
E
|
330 |
L
|
T
|
G
|
D
|
P
|
N
|
K
|
T
|
R
|
G
|
340 |
A
|
P
|
E
|
A
|
L
|
M
|
A
|
N
|
S
|
G
|
350 |
E
|
P
|
W
|
S
|
P
|
S
|
Y
|
L
|
G
|
P
|
360 |
T
|
S
|
P
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
β-D-hydroxybutyric acid, butyric acid