HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Feb. 26, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL2057618 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

butyric acid, β-D-hydroxybutyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 P 132 - G.H5 N 347 G.H5.19
Hydrophobic TM6 I 226 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 226 6x30 G.H5 F 354 G.H5.26
Polar TM7 S 297 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 S 297 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 297 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL3 M 220 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 220 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 220 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Polar C-term S 298 - G.H5 L 353 G.H5.25
Polar TM6 K 225 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 225 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM7 S 297 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic C-term S 298 - G.H5 G 352 G.H5.24
Van-der-waals C-term S 298 - G.H5 G 352 G.H5.24
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Polar TM6 R 228 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 228 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 228 6x32 G.H5 F 354 G.H5.26
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 M 220 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 220 - G.H5 K 345 G.H5.17
Polar TM6 H 223 6x27 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 H 223 6x27 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 H 223 6x27 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 225 6x29 G.H5 K 349 G.H5.21
Hydrophobic TM6 F 232 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 132 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 132 - G.H5 I 343 G.H5.15
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 H 133 - G.H5 F 336 G.H5.08
Ionic ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 H 133 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 133 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 H 133 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 H 133 - G.S3 L 194 G.S3.01
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 125 3x50 G.H5 L 353 G.H5.25
Polar ICL2 H 133 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 133 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 - G.H5 T 340 G.H5.12
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25