HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Aug. 30, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

MK 6892 - Agonist pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

β-D-hydroxybutyric acid, butyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
A02G.hns1D09G.h4s6D09T12D13D22C23G24G.H5GproteinR5x68H6x27R3x53P-K-S2x39H-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.h4s6G.H5GPCR segments:TM2ICL2TM3TM5TM6C-term

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x545x655x686x276x296x306x336x366x37G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.09G.H5.08G.h4s6.09G.S3.01G.hns1.03G.hns1.02Res. Pos.HCA2 (8IHF)- (8IHF)-------------SRRVLRHKIAFISRRVLRHKIAFIHDCLNILDTDKDFFIGLAR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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