HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Sept. 6, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

compound 9n [PMID: 18752940] - PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

β-D-hydroxybutyric acid, butyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
D09E12G.h4s6D13N19D22G.H5GproteinH-K-R3x53R-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM3ICL3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x373x503x533x545x656x37G.H5.26G.H5.25G.H5.24G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.h4s6.12G.h4s6.09G.S3.01G.hns1.03G.hns1.02Res. Pos.HCA2 (8JHY)- (8JHY)-------KRRVLIKRRVLIHDLNLITDIKGFLDEAR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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