GPR52 (gpr52_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR52
GENE
GPR52 (ECO:0000312|HGNC:HGNC:4508})
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 52
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
E
|
S
|
R
|
W
|
T
|
E
|
W
|
R
|
10 |
I
|
L
|
N
|
M
|
S
|
S
|
G
|
I
|
V
|
N
|
20 |
V
|
S
|
E
|
R
|
H
|
S
|
C
|
P
|
L
|
G
|
30 |
F
|
G
|
H
|
Y
|
S
|
V
|
V
|
D
|
V
|
C
|
40 |
TM1 | |||||||||
I
|
F
|
E
|
T
|
V
|
V
|
I
|
V
|
L
|
L
|
50 |
T
|
F
|
L
|
I
|
I
|
A
|
G
|
N
|
L
|
T
|
60 |
V
|
I
|
F
|
V
|
F
|
H
|
C
|
A
|
P
|
L
|
70 |
ICL1 | TM2 | ||||||||
L
|
H
|
H
|
Y
|
T
|
T
|
S
|
Y
|
F
|
I
|
80 |
Q
|
T
|
M
|
A
|
Y
|
A
|
D
|
L
|
F
|
V
|
90 |
G
|
V
|
S
|
C
|
L
|
V
|
P
|
T
|
L
|
S
|
100 |
ECL1 | |||||||||
L
|
L
|
H
|
Y
|
S
|
T
|
G
|
V
|
H
|
E
|
110 |
TM3 | |||||||||
S
|
L
|
T
|
C
|
Q
|
V
|
F
|
G
|
Y
|
I
|
120 |
I
|
S
|
V
|
L
|
K
|
S
|
V
|
S
|
M
|
A
|
130 |
C
|
L
|
A
|
C
|
I
|
S
|
V
|
D
|
R
|
Y
|
140 |
ICL2 | |||||||||
L
|
A
|
I
|
T
|
K
|
P
|
L
|
S
|
Y
|
N
|
150 |
TM4 | |||||||||
Q
|
L
|
V
|
T
|
P
|
C
|
R
|
L
|
R
|
I
|
160 |
C
|
I
|
I
|
L
|
I
|
W
|
I
|
Y
|
S
|
C
|
170 |
L
|
I
|
F
|
L
|
P
|
S
|
F
|
F
|
G
|
W
|
180 |
ECL2 | |||||||||
G
|
K
|
P
|
G
|
Y
|
H
|
G
|
D
|
I
|
F
|
190 |
E
|
W
|
C
|
A
|
T
|
S
|
W
|
L
|
T
|
S
|
200 |
TM5 | |||||||||
A
|
Y
|
F
|
T
|
G
|
F
|
I
|
V
|
C
|
L
|
210 |
L
|
Y
|
A
|
P
|
A
|
A
|
F
|
V
|
V
|
C
|
220 |
F
|
T
|
Y
|
F
|
H
|
I
|
F
|
K
|
I
|
C
|
230 |
R
|
Q
|
H
|
T
|
K
|
E
|
I
|
N
|
D
|
R
|
240 |
ICL3 | |||||||||
R
|
A
|
R
|
F
|
P
|
S
|
H
|
E
|
V
|
D
|
250 |
TM6 | |||||||||
S
|
S
|
R
|
E
|
T
|
G
|
H
|
S
|
P
|
D
|
260 |
R
|
R
|
Y
|
A
|
M
|
V
|
L
|
F
|
R
|
I
|
270 |
T
|
S
|
V
|
F
|
Y
|
M
|
L
|
W
|
L
|
P
|
280 |
Y
|
I
|
I
|
Y
|
F
|
L
|
L
|
E
|
S
|
S
|
290 |
ECL3 | TM7 | ||||||||
R
|
V
|
L
|
D
|
N
|
P
|
T
|
L
|
S
|
F
|
300 |
L
|
T
|
T
|
W
|
L
|
A
|
I
|
S
|
N
|
S
|
310 |
F
|
C
|
N
|
C
|
V
|
I
|
Y
|
S
|
L
|
S
|
320 |
H8 | |||||||||
N
|
S
|
V
|
F
|
R
|
L
|
G
|
L
|
R
|
R
|
330 |
L
|
S
|
E
|
T
|
M
|
C
|
T
|
S
|
C
|
M
|
340 |
C-term | |||||||||
C
|
V
|
K
|
D
|
Q
|
E
|
A
|
Q
|
E
|
P
|
350 |
K
|
P
|
R
|
K
|
R
|
A
|
N
|
S
|
C
|
S
|
360 |
I
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available