GPR52 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HMP

RESOLUTION

2.8 Å

REFERENCE

10.1002/MCO2.260

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

derivative 17 [Nakahata et al., 2018] - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 269 6x39 G.H5 Y 391 G.H5.23
Polar TM5 H 233 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 233 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 233 5x69 G.H5 Q 384 G.H5.16
Polar TM5 R 240 5x76 G.S6 C 359 G.S6.01
Hydrophobic TM5 R 240 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 240 5x76 G.S6 C 359 G.S6.01
Hydrophobic TM5 R 240 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 R 240 5x76 G.S6 P 361 G.S6.03
Polar TM6 M 265 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM6 M 265 6x35 G.H5 Y 391 G.H5.23
Van-der-waals TM6 M 265 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM5 F 244 5x80 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 F 244 5x80 G.h4s6 T 350 G.h4s6.03
Aromatic ICL1 Y 74 - G.HN K 34 G.HN.51
Hydrophobic ICL1 Y 74 - G.HN K 34 G.HN.51
Van-der-waals ICL1 Y 74 - G.HN K 34 G.HN.51
Hydrophobic TM4 P 155 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM5 F 244 5x80 G.H4 R 347 G.H4.17
Hydrophobic ICL2 L 147 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 147 - G.H5 I 383 G.H5.15
Hydrophobic TM5 F 244 5x80 G.H4 L 346 G.H4.16
Van-der-waals TM5 F 244 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM6 A 264 6x34 G.H5 Q 390 G.H5.22
Polar TM6 Y 263 6x33 G.H5 Q 390 G.H5.22
Hydrophobic TM6 M 265 6x35 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 147 - G.H5 R 380 G.H5.12
Hydrophobic TM6 F 268 6x38 G.H5 Y 391 G.H5.23
Van-der-waals TM6 F 268 6x38 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 229 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 229 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 146 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 146 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 S 246 - G.h4s6 A 351 G.h4s6.04
Hydrophobic TM6 F 268 6x38 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 229 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 147 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 147 - G.H5 F 376 G.H5.08
Van-der-waals TM5 F 227 5x63 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 233 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 237 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 237 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 R 240 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 R 240 5x76 G.H4 L 346 G.H4.16
Polar TM5 H 233 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 233 5x69 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 147 - G.S3 V 217 G.S3.01
Ionic TM5 R 243 5x79 G.H4 D 343 G.H4.13
Polar TM5 R 243 5x79 G.H4 D 343 G.H4.13
Van-der-waals TM5 R 243 5x79 G.H4 D 343 G.H4.13
Ionic TM5 E 236 5x72 G.H5 R 385 G.H5.17
Polar TM5 E 236 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 237 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 237 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 H 233 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 233 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 147 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 L 147 - G.S3 F 219 G.S3.03
Hydrophobic TM5 C 230 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 C 230 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Polar ICL3 S 246 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 S 246 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 S 246 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 I 226 5x62 G.H5 Y 391 G.H5.23
Van-der-waals TM5 I 226 5x62 G.H5 Y 391 G.H5.23
Hydrophobic TM5 C 230 5x66 G.H5 L 394 G.H5.26
Van-der-waals TM5 C 230 5x66 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 146 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 226 5x62 G.H5 L 388 G.H5.20
Polar TM6 M 265 6x35 G.H5 Q 390 G.H5.22
Polar ICL2 L 147 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 147 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 147 - G.S1 H 41 G.S1.02
Polar ICL2 N 150 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 150 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 147 - G.H5 C 379 G.H5.11
Polar TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 F 244 5x80 G.H4 D 343 G.H4.13
Van-der-waals TM5 F 244 5x80 G.H4 D 343 G.H4.13
Hydrophobic TM3 I 143 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 143 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 R 240 5x76 G.h4s6 T 350 G.h4s6.03
Polar TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 Q 151 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 Q 151 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM6 A 264 6x34 G.H5 Y 391 G.H5.23
Van-der-waals TM6 A 264 6x34 G.H5 Y 391 G.H5.23
Polar TM5 C 230 5x66 G.H5 E 392 G.H5.24
Hydrophobic TM5 C 230 5x66 G.H5 E 392 G.H5.24
Van-der-waals TM5 C 230 5x66 G.H5 E 392 G.H5.24
Hydrophobic TM6 M 265 6x35 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 146 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 243 5x79 G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 Q 151 - G.hns1 A 39 G.hns1.03