MC5 receptor (mc5r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC5 receptor
GENE
MC5R
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Melanocortin receptor 5, MC5-R, MC-2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
S
|
S
|
F
|
H
|
L
|
H
|
F
|
L
|
10 |
D
|
L
|
N
|
L
|
N
|
A
|
T
|
E
|
G
|
N
|
20 |
L
|
S
|
G
|
P
|
N
|
V
|
K
|
N
|
K
|
S
|
30 |
S
|
P
|
C
|
E
|
D
|
M
|
G
|
I
|
A
|
V
|
40 |
TM1 | |||||||||
E
|
V
|
F
|
L
|
T
|
L
|
G
|
V
|
I
|
S
|
50 |
L
|
L
|
E
|
N
|
I
|
L
|
V
|
I
|
G
|
A
|
60 |
ICL1 | |||||||||
I
|
V
|
K
|
N
|
K
|
N
|
L
|
H
|
S
|
P
|
70 |
TM2 | |||||||||
M
|
Y
|
F
|
F
|
V
|
C
|
S
|
L
|
A
|
V
|
80 |
A
|
D
|
M
|
L
|
V
|
S
|
M
|
S
|
S
|
A
|
90 |
W
|
E
|
T
|
I
|
T
|
I
|
Y
|
L
|
L
|
N
|
100 |
ECL1 | TM3 | ||||||||
N
|
K
|
H
|
L
|
V
|
I
|
A
|
D
|
A
|
F
|
110 |
V
|
R
|
H
|
I
|
D
|
N
|
V
|
F
|
D
|
S
|
120 |
M
|
I
|
C
|
I
|
S
|
V
|
V
|
A
|
S
|
M
|
130 |
C
|
S
|
L
|
L
|
A
|
I
|
A
|
V
|
D
|
R
|
140 |
ICL2 | |||||||||
Y
|
V
|
T
|
I
|
F
|
Y
|
A
|
L
|
R
|
Y
|
150 |
TM4 | |||||||||
H
|
H
|
I
|
M
|
T
|
A
|
R
|
R
|
S
|
G
|
160 |
A
|
I
|
I
|
A
|
G
|
I
|
W
|
A
|
F
|
C
|
170 |
T
|
G
|
C
|
G
|
I
|
V
|
F
|
I
|
L
|
Y
|
180 |
ECL2 | TM5 | ||||||||
S
|
E
|
S
|
T
|
Y
|
V
|
I
|
L
|
C
|
L
|
190 |
I
|
S
|
M
|
F
|
F
|
A
|
M
|
L
|
F
|
L
|
200 |
L
|
V
|
S
|
L
|
Y
|
I
|
H
|
M
|
F
|
L
|
210 |
L
|
A
|
R
|
T
|
H
|
V
|
K
|
R
|
I
|
A
|
220 |
ICL3 | |||||||||
A
|
L
|
P
|
G
|
A
|
S
|
S
|
A
|
R
|
Q
|
230 |
TM6 | |||||||||
R
|
T
|
S
|
M
|
Q
|
G
|
A
|
V
|
T
|
V
|
240 |
T
|
M
|
L
|
L
|
G
|
V
|
F
|
T
|
V
|
C
|
250 |
W
|
A
|
P
|
F
|
F
|
L
|
H
|
L
|
T
|
L
|
260 |
ECL3 | |||||||||
M
|
L
|
S
|
C
|
P
|
Q
|
N
|
L
|
Y
|
C
|
270 |
TM7 | |||||||||
S
|
R
|
F
|
M
|
S
|
H
|
F
|
N
|
M
|
Y
|
280 |
L
|
I
|
L
|
I
|
M
|
C
|
N
|
S
|
V
|
M
|
290 |
H8 | |||||||||
D
|
P
|
L
|
I
|
Y
|
A
|
F
|
R
|
S
|
Q
|
300 |
E
|
M
|
R
|
K
|
T
|
F
|
K
|
E
|
I
|
I
|
310 |
C-term | |||||||||
C
|
C
|
R
|
G
|
F
|
R
|
I
|
A
|
C
|
S
|
320 |
F
|
P
|
R
|
R
|
D
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
γ-MSH, agouti-related protein, β-MSH, α-MSH, ACTH
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page