MC5 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K3H

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.STR.2025.03.004

PUBLICATION DATE

Aug. 6, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

ACTH (Human), ACTH (Mouse), β-MSH (Human), α-MSH (Human), β-MSH (Mouse), γ-MSH (Human), β-MSH (Rat), agouti-related protein (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 211 5x64 G.H5 L 388 G.H5.20
Polar TM5 H 215 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 215 5x68 G.H5 Q 384 G.H5.16
Polar ICL2 R 149 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 V 216 5x69 G.H5 L 394 G.H5.26
Polar TM6 G 236 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 236 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 236 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 223 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 A 147 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 147 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 212 5x65 G.H5 L 388 G.H5.20
Polar TM6 Q 235 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 235 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 Q 235 6x32 G.H5 E 392 G.H5.24
Polar ICL2 L 148 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 148 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 148 34x51 G.S1 H 41 G.S1.02
Polar ICL3 G 224 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 G 224 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 G 224 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 H 215 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 215 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 M 208 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 219 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 219 5x72 G.H5 R 385 G.H5.17
Polar TM6 T 239 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 239 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 E 392 G.H5.24
Polar TM5 H 215 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 215 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 215 5x68 G.H5 R 385 G.H5.17
Ionic TM5 R 218 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 218 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 218 5x71 G.H5 D 381 G.H5.13
Aromatic TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 144 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 144 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 148 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM3 I 144 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 147 34x50 G.H5 Q 384 G.H5.16
Polar ICL2 H 151 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 151 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 151 34x54 G.hns1 R 38 G.hns1.02
Polar TM3 I 144 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 144 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 144 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 144 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 144 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 V 240 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 149 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 149 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL3 P 223 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 P 223 - G.H4 L 346 G.H4.16
Hydrophobic TM5 I 219 5x72 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 148 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM2 M 71 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 71 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 219 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 219 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 148 34x51 G.H5 C 379 G.H5.11
Polar TM3 T 143 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 T 143 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 143 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM7 R 298 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 148 34x51 G.H5 I 383 G.H5.15
Polar TM3 D 139 3x49 G.H5 Y 391 G.H5.23
Polar TM3 T 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 T 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 T 239 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 239 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM4 T 155 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 155 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL3 L 222 - G.H4 L 346 G.H4.16
Hydrophobic TM5 L 211 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 215 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 F 209 5x62 G.H5 L 393 G.H5.25
Hydrophobic ICL2 H 152 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 H 152 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 L 222 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 212 5x65 G.H5 L 393 G.H5.25