MRGPRG (mrgrg_human)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRG

GENE

MRGPRG (GPR169, MRGG)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Mas-related G-protein coupled receptor member G, G-protein coupled receptor 169

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
F
G
L
F
G
L
W
R
T
10
  TM1            
F
D
S
V
V
F
Y
L
T
L
20
                   
I
V
G
L
G
G
P
V
G
N
30
                   
G
L
V
L
W
N
L
G
F
R
40
  ICL1 TM2    
I
K
K
G
P
F
S
I
Y
L
50
                   
L
H
L
A
A
A
D
F
L
F
60
                   
L
S
C
R
V
G
F
S
V
A
70
ECL1     TM3  
Q
A
A
L
G
A
Q
D
T
L
80
                   
Y
F
V
L
T
F
L
W
F
A
90
                   
V
G
L
W
L
L
A
A
F
S
100
                   
V
E
R
C
L
S
D
L
F
P
110
ICL2       TM4
A
C
Y
Q
G
C
R
P
R
H
120
                   
A
S
A
V
L
C
A
L
V
W
130
                   
T
P
T
L
P
A
V
P
L
P
140
        ECL2    
A
N
A
C
G
L
L
R
N
S
150
      TM5        
A
C
P
L
V
C
P
R
Y
H
160
                   
V
A
S
V
T
W
F
L
V
L
170
                   
A
R
V
A
W
T
A
G
V
V
180
                   
L
F
V
W
V
T
C
C
S
T
190
ICL3 TM6      
R
P
R
P
R
L
Y
G
I
V
200
                   
L
G
A
L
L
L
L
F
F
C
210
                   
G
L
P
S
V
F
Y
W
S
L
220
        ECL3    
Q
P
L
L
N
F
L
L
P
V
230
TM7              
F
S
P
L
A
T
L
L
A
C
240
                   
V
N
S
S
S
K
P
L
I
Y
250
      H8          
S
G
L
G
R
Q
P
G
K
R
260
                   
E
P
L
R
S
V
L
R
R
A
270
C-term        
L
G
E
G
A
E
L
G
A
R
280
                 
G
Q
S
L
P
M
G
L
L

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 K K ICL1ECL1 Q A A L G A ECL1ICL2 P A C Y Q G C R ICL2ECL2 G L L R N S A C P ECL2ICL3 T R P ICL3ECL3 N F L L ECL3N-term M F G L F G L W R T F N-termC-term R A L G E G A E L G A R G Q S L P M G L L C-term D S V V F Y L T L I V G L G G P V G N G L V L W N L G F R I G P F S I Y L L H L A A A D F L F L S C R V G F S V A Q D T L Y F V L T F L W F A V G L W L L A A F S V E R C L S D L F P R H A S A V L C A L V W T P T L P A V P L P A N A C L V C P R Y H V A S V T W F L V L A R V A W T A G V V L F V W V T C C S R P R L Y G I V L G A L L L L F F C G L P S V F Y W S L Q P L L P V F S P L A T L L A C V N S S S K P L I Y S G L G R Q E P L R P G K R R S V L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G V P G G L G V I L T L Y F V V S D 1 L H L A A A D F L F L S C R V G F S V A 2 A A L L W L G V A F W L F T L V F Y L T 3 S A V L C A L V W T P T L P A V P L P A 4 V V G A T W A V R A L V L F W T V S A V 5 L G A L L L L F F C G L P S V F Y W S L 6 L P K S S S N V C A L L T A L P S F V 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

mrgrg_human active,

mrgrg_human inactive

STRUCTURES

No structures available