MRGPRG homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

MRGPRG

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

AT2 receptor (sequence similarity: 24%) PDB: 5UNG
Align

TEMPLATES

6D27 (DP2 receptor)
5UNG (AT2 receptor)
4XNW (P2Y1 receptor)
6OMM (FPR2/ALX)
3VW7 (PAR1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.2 18.5 8.3
Side-chains 15.1 58.5 26.4

Number of backbone templates: 5
Number of rotamer templates: 48

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 12 D 1.32x32 DP2 receptor 6D27 DP2 receptor 6D27
TM1 13 S 1.33x33 AT2 receptor 5UNG - -
TM1 14 V 1.34x34 AT2 receptor 5UNG OX2 receptor 7L1V
TM1 15 V 1.35x35 AT2 receptor 5UNG CXCR2 6LFO
TM1 16 F 1.36x36 AT2 receptor 5UNG FFA1 receptor 5TZY
TM1 17 Y 1.37x37 AT2 receptor 5UNG - -
TM1 18 L 1.38x38 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 19 T 1.39x39 AT2 receptor 5UNG M1 receptor 6OIJ
TM1 20 L 1.40x40 AT2 receptor 5UNG CB1 receptor 5XRA
TM1 21 I 1.41x41 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 22 V 1.42x42 AT2 receptor 5UNG CXCR2 6LFO
TM1 23 G 1.43x43 AT2 receptor 5UNG CB1 receptor 6N4B
TM1 24 L 1.44x44 AT2 receptor 5UNG CXCR2 6LFO
TM1 25 G 1.45x45 AT2 receptor 5UNG NOP receptor 5DHG
TM1 26 G 1.46x46 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 27 P 1.47x47 AT2 receptor 5UNG - -
TM1 28 V 1.48x48 AT2 receptor 5UNG κ receptor 6B73
TM1 29 G 1.49x49 AT2 receptor 5UNG AT1 receptor 6DO1
TM1 30 N 1.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 31 G 1.51x51 AT2 receptor 5UNG FPR2/ALX 6OMM
TM1 32 L 1.52x52 AT2 receptor 5UNG AT1 receptor 6DO1
TM1 33 V 1.53x53 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 34 L 1.54x54 AT2 receptor 5UNG CB1 receptor 6N4B
TM1 35 W 1.55x55 AT2 receptor 5UNG FPR2/ALX 6OMM
TM1 36 N 1.56x56 AT2 receptor 5UNG - -
TM1 37 L 1.57x57 AT2 receptor 5UNG EP4 receptor 7D7M
TM1 38 G 1.58x58 AT2 receptor 5UNG FPR2/ALX 6OMM
TM1 39 F 1.59x59 AT2 receptor 5UNG AT1 receptor 6DO1
TM1 40 R 1.60x60 DP2 receptor 6D27 DP2 receptor 6D27
ICL1 41 I - - - - -
ICL1 42 K - DP2 receptor 6D27 - -
ICL1 43 K - - - - -
TM2 44 G 2.37x37 DP2 receptor 6D27 - -
TM2 45 P 2.38x38 AT2 receptor 5UNG CB2 receptor 6PT0
TM2 46 F 2.39x39 AT2 receptor 5UNG EP3 receptor 6AK3
TM2 47 S 2.40x40 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 48 I 2.41x41 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 49 Y 2.42x42 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 50 L 2.43x43 AT2 receptor 5UNG AT1 receptor 6DO1
TM2 51 L 2.44x44 AT2 receptor 5UNG AT1 receptor 6DO1
TM2 52 H 2.45x45 AT2 receptor 5UNG DP2 receptor 6D27
TM2 53 L 2.46x46 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 54 A 2.47x47 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 55 A 2.48x48 AT2 receptor 5UNG US28 5WB1
TM2 56 A 2.49x49 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 57 D 2.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 58 F 2.51x51 AT2 receptor 5UNG FPR2/ALX 6OMM
TM2 59 L 2.52x52 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 60 F 2.53x53 AT2 receptor 5UNG AT1 receptor 6DO1
TM2 61 L 2.54x54 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 62 S 2.55x55 AT2 receptor 5UNG μ receptor 5C1M
TM2 63 C 2.56x56 AT2 receptor 5UNG OX2 receptor 7L1V
TM2 64 R 2.57x57 AT2 receptor 5UNG - -
TM2 65 V 2.58x58 AT2 receptor 5UNG CB1 receptor 6N4B
TM2 66 G 2.59x59 AT2 receptor 5UNG - -
TM2 67 F 2.60x60 AT2 receptor 5UNG DP2 receptor 6D27
TM2 68 S 2.61x61 AT2 receptor 5UNG μ receptor 5C1M
TM2 69 V 2.62x62 AT2 receptor 5UNG AT1 receptor 6DO1
TM2 70 A 2.63x63 AT2 receptor 5UNG 5-HT2C receptor 6BQG
ECL1 71 Q - - - - -
ECL1 72 A - - - - -
ECL1 73 A - - - - -
ECL1 74 L - - - - -
ECL1 75 G - - - - -
ECL1 76 A - - - - -
TM3 77 Q 3.24x24 AT2 receptor 5UNG S1P1 receptor 3V2Y
TM3 78 D 3.25x25 AT2 receptor 5UNG MC4 receptor 6W25
TM3 79 T 3.26x26 AT2 receptor 5UNG US28 5WB1
TM3 80 L 3.27x27 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 81 Y 3.28x28 AT2 receptor 5UNG NTS1 receptor 6OSA
TM3 82 F 3.29x29 AT2 receptor 5UNG CCR7 6QZH
TM3 83 V 3.30x30 AT2 receptor 5UNG CXCR4 3ODU
TM3 84 L 3.31x31 AT2 receptor 5UNG CXCR2 6LFO
TM3 85 T 3.32x32 AT2 receptor 5UNG - -
TM3 86 F 3.33x33 AT2 receptor 5UNG DP2 receptor 6D27
TM3 87 L 3.34x34 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 88 W 3.35x35 AT2 receptor 5UNG - -
TM3 89 F 3.36x36 AT2 receptor 5UNG CXCR2 6LFO
TM3 90 A 3.37x37 AT2 receptor 5UNG A2A receptor 4UHR
TM3 91 V 3.38x38 AT2 receptor 5UNG OX2 receptor 7L1V
TM3 92 G 3.39x39 AT2 receptor 5UNG CXCR2 6LFO
TM3 93 L 3.40x40 AT2 receptor 5UNG US28 5WB1
TM3 94 W 3.41x41 AT2 receptor 5UNG AT2 receptor 7C6A
TM3 95 L 3.42x42 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 96 L 3.43x43 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 97 A 3.44x44 AT2 receptor 5UNG CXCR2 6LFO
TM3 98 A 3.45x45 AT2 receptor 5UNG EP3 receptor 6AK3
TM3 99 F 3.46x46 AT2 receptor 5UNG - -
TM3 100 S 3.47x47 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 101 V 3.48x48 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 102 E 3.49x49 AT2 receptor 5UNG EP3 receptor 6AK3
TM3 103 R 3.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 104 C 3.51x51 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 105 L 3.52x52 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 106 S 3.53x53 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 107 D 3.54x54 AT2 receptor 5UNG - -
TM3 108 L 3.55x55 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 109 F 3.56x56 AT2 receptor 5UNG CysLT1 receptor 6RZ4
ICL2 110 P 34.50x50 - - - -
ICL2 111 A 34.51x51 DP2 receptor 6D27 C5a1 receptor 5O9H
ICL2 112 C 34.52x52 DP2 receptor 6D27 - -
ICL2 113 Y 34.53x53 DP2 receptor 6D27 CB1 receptor 6N4B
ICL2 114 Q 34.54x54 DP2 receptor 6D27 DP2 receptor 6D27
ICL2 115 G 34.55x55 DP2 receptor 6D27 A2A receptor 4UHR
ICL2 116 C 34.56x56 DP2 receptor 6D27 - -
ICL2 117 R 34.57x57 - - - -
TM4 118 P 4.38x38 DP2 receptor 6D27 US28 5WB1
TM4 119 R 4.39x39 DP2 receptor 6D27 CB1 receptor 6N4B
TM4 120 H 4.40x40 DP2 receptor 6D27 - -
TM4 121 A 4.41x41 AT2 receptor 5UNG EP3 receptor 6M9T
TM4 122 S 4.42x42 AT2 receptor 5UNG CCR6 6WWZ
TM4 123 A 4.43x43 AT2 receptor 5UNG A1 receptor 6D9H
TM4 124 V 4.44x44 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 125 L 4.45x45 AT2 receptor 5UNG D1 receptor 7JVQ
TM4 126 C 4.46x46 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 127 A 4.47x47 AT2 receptor 5UNG A2A receptor 4UHR
TM4 128 L 4.48x48 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 129 V 4.49x49 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 130 W 4.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 131 T 4.51x51 AT2 receptor 5UNG CB1 receptor 5XRA
TM4 132 P 4.52x52 AT2 receptor 5UNG CXCR4 3ODU
TM4 133 T 4.53x53 AT2 receptor 5UNG MT2 receptor 6ME7
TM4 134 L 4.54x54 AT2 receptor 5UNG FPR2/ALX 6OMM
TM4 135 P 4.55x55 AT2 receptor 5UNG - -
TM4 136 A 4.56x56 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 137 V 4.57x57 P2Y1 receptor 4XNW PAR1 3VW7
TM4 138 P 4.58x58 P2Y1 receptor 4XNW - -
TM4 139 L 4.59x59 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 140 P 4.60x60 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 141 A 4.61x61 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 142 N 4.62x62 AT2 receptor 5UNG - -
TM4 143 A 4.63x63 AT2 receptor 5UNG OX1 receptor 6TO7
TM4 144 C 4.64x64 AT2 receptor 5UNG - -
ECL2 145 G - - - - -
ECL2 146 L - - - - -
ECL2 147 L - - - - -
TM5 148 R 5.26x26 FPR2/ALX 6OMM - -
TM5 149 N 5.27x27 FPR2/ALX 6OMM - -
TM5 150 S 5.28x28 FPR2/ALX 6OMM - -
TM5 151 A 5.29x29 FPR2/ALX 6OMM - -
TM5 152 C 5.30x30 FPR2/ALX 6OMM - -
TM5 153 P 5.31x31 AT2 receptor 5UNG δ receptor 6PT2
TM5 154 L 5.32x32 AT2 receptor 5UNG PAR2 5NDD
TM5 155 V 5.33x33 AT2 receptor 5UNG PAR2 5NDD
TM5 156 C 5.34x34 AT2 receptor 5UNG - -
TM5 157 P 5.35x35 AT2 receptor 5UNG PAF receptor 5ZKQ
TM5 158 R 5.36x36 AT2 receptor 5UNG CXCR2 6LFO
TM5 159 Y 5.37x37 AT2 receptor 5UNG PAR1 3VW7
TM5 160 H 5.38x38 AT2 receptor 5UNG S1P1 receptor 3V2Y
TM5 161 V 5.39x39 AT2 receptor 5UNG NTS1 receptor 6OSA
TM5 162 A 5.40x40 AT2 receptor 5UNG AT2 receptor 5UNG
TM5 163 S 5.41x41 AT2 receptor 5UNG EP3 receptor 6AK3
TM5 164 V 5.42x42 AT2 receptor 5UNG NTS1 receptor 6OSA
TM5 165 T 5.43x43 AT2 receptor 5UNG M1 receptor 6OIJ
TM5 166 W 5.44x44 AT2 receptor 5UNG - -
TM5 167 F 5.45x45 AT2 receptor 5UNG EP3 receptor 6AK3
TM5 168 L 5.46x46 PAR1 3VW7 AT2 receptor 5UNG
TM5 169 V 5.47x47 PAR1 3VW7 CB1 receptor 5XRA
TM5 170 L 5.48x48 AT2 receptor 5UNG AT1 receptor 6DO1
TM5 171 A 5.49x49 AT2 receptor 5UNG OX2 receptor 7L1V
TM5 172 R 5.50x50 AT2 receptor 5UNG - -
TM5 173 V 5.51x51 AT2 receptor 5UNG μ receptor 5C1M
TM5 174 A 5.52x52 AT2 receptor 5UNG GPR52 6LI3
TM5 175 W 5.53x53 AT2 receptor 5UNG - -
TM5 176 T 5.54x54 AT2 receptor 5UNG EP3 receptor 6AK3
TM5 177 A 5.55x55 AT2 receptor 5UNG AT2 receptor 5UNG
TM5 178 G 5.56x56 AT2 receptor 5UNG A2A receptor 4UHR
TM5 179 V 5.57x57 AT2 receptor 5UNG A2A receptor 4UHR
TM5 180 V 5.58x58 AT2 receptor 5UNG - -
TM5 181 L 5.59x59 AT2 receptor 5UNG OX2 receptor 7L1V
TM5 182 F 5.60x60 AT2 receptor 5UNG CXCR2 6LFO
TM5 183 V 5.61x61 AT2 receptor 5UNG CB2 receptor 6PT0
TM5 184 W 5.62x62 AT2 receptor 5UNG AT1 receptor 6DO1
TM5 185 V 5.63x63 AT2 receptor 5UNG D3 receptor 7CMV
TM5 186 T 5.64x64 AT2 receptor 5UNG CXCR2 6LFO
TM5 187 C 5.65x65 AT2 receptor 5UNG - -
TM5 188 C 5.66x66 AT2 receptor 5UNG GPR52 6LI3
TM5 189 S 5.67x67 AT2 receptor 5UNG μ receptor 5C1M
ICL3 190 T - AT2 receptor 5UNG - -
ICL3 191 R - AT2 receptor 5UNG - -
ICL3 192 P - AT2 receptor 5UNG - -
TM6 193 R 6.30x30 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 194 P 6.31x31 AT2 receptor 5UNG - -
TM6 195 R 6.32x32 AT2 receptor 5UNG FPR2/ALX 6OMM
TM6 196 L 6.33x33 AT2 receptor 5UNG CB1 receptor 6N4B
TM6 197 Y 6.34x34 AT2 receptor 5UNG - -
TM6 198 G 6.35x35 AT2 receptor 5UNG - -
TM6 199 I 6.36x36 AT2 receptor 5UNG AT1 receptor 6DO1
TM6 200 V 6.37x37 AT2 receptor 5UNG μ receptor 5C1M
TM6 201 L 6.38x38 AT2 receptor 5UNG μ receptor 5C1M
TM6 202 G 6.39x39 AT2 receptor 5UNG EP3 receptor 6AK3
TM6 203 A 6.40x40 AT2 receptor 5UNG GPBA receptor 7CFN
TM6 204 L 6.41x41 AT2 receptor 5UNG OX2 receptor 7L1V
TM6 205 L 6.42x42 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 206 L 6.43x43 AT2 receptor 5UNG A2A receptor 4UHR
TM6 207 L 6.44x44 AT2 receptor 5UNG EP3 receptor 6AK3
TM6 208 F 6.45x45 AT2 receptor 5UNG AT1 receptor 6DO1
TM6 209 F 6.46x46 AT2 receptor 5UNG AT1 receptor 6DO1
TM6 210 C 6.47x47 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 211 G 6.48x48 AT2 receptor 5UNG - -
TM6 212 L 6.49x49 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 213 P 6.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 214 S 6.51x51 AT2 receptor 5UNG PAR2 5NDD
TM6 215 V 6.52x52 AT2 receptor 5UNG EP4 receptor 7D7M
TM6 216 F 6.53x53 AT2 receptor 5UNG α2B-adrenoceptor 6K42
TM6 217 Y 6.54x54 AT2 receptor 5UNG μ receptor 5C1M
TM6 218 W 6.55x55 AT2 receptor 5UNG - -
TM6 219 S 6.56x56 AT2 receptor 5UNG α2B-adrenoceptor 6K42
TM6 220 L 6.57x57 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 221 Q 6.58x58 AT2 receptor 5UNG CCR7 6QZH
TM6 222 P 6.59x59 AT2 receptor 5UNG D1 receptor 7JVQ
TM6 223 L 6.60x60 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 224 L 6.61x61 AT2 receptor 5UNG PAR2 5NDD
ECL3 225 N - - - - -
ECL3 226 F - - - - -
ECL3 227 L - - - - -
ECL3 228 L - - - - -
TM7 229 P 7.32x31 AT2 receptor 5UNG GPR52 6LI3
TM7 230 V 7.33x32 AT2 receptor 5UNG μ receptor 5C1M
TM7 231 F 7.34x33 AT2 receptor 5UNG EP3 receptor 6AK3
TM7 232 S 7.35x34 AT2 receptor 5UNG GPR52 6LI3
TM7 233 P 7.36x35 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 234 L 7.37x36 AT2 receptor 5UNG US28 5WB1
TM7 235 A 7.38x37 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 236 T 7.39x38 AT2 receptor 5UNG GPR52 6LI3
TM7 237 L 7.40x39 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 238 L 7.41x40 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 239 A 7.42x41 AT2 receptor 5UNG AT1 receptor 6DO1
TM7 240 C 7.43x42 AT2 receptor 5UNG CCR7 6QZH
TM7 241 V 7.44x43 AT2 receptor 5UNG EP4 receptor 7D7M
TM7 242 N 7.45x45 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 243 S 7.46x46 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 244 S 7.47x47 AT2 receptor 5UNG κ receptor 6B73
TM7 245 S 7.48x48 AT2 receptor 5UNG - -
TM7 246 K 7.49x49 DP2 receptor 6D27 OT receptor 6TPK
TM7 247 P 7.50x50 DP2 receptor 6D27 DP2 receptor 6D27
TM7 248 L 7.51x51 DP2 receptor 6D27 AT1 receptor 6DO1
TM7 249 I 7.52x52 DP2 receptor 6D27 CXCR2 6LFO
TM7 250 Y 7.53x53 DP2 receptor 6D27 DP2 receptor 6D27
TM7 251 S 7.54x54 DP2 receptor 6D27 GPR52 6LI3
TM7 252 G 7.55x55 DP2 receptor 6D27 - -
TM7 253 L 7.56x56 DP2 receptor 6D27 AT1 receptor 6DO1
H8 254 G 8.47x47 DP2 receptor 6D27 AT2 receptor 5UNG
H8 255 R 8.48x48 DP2 receptor 6D27 A2A receptor 4UHR
H8 256 Q 8.49x49 DP2 receptor 6D27 Rhodopsin 4X1H
H8 257 P 8.50x50 DP2 receptor 6D27 - -
H8 258 G 8.51x51 DP2 receptor 6D27 - -
H8 259 K 8.52x52 DP2 receptor 6D27 D2 receptor 7JVR
H8 260 R 8.53x53 DP2 receptor 6D27 FPR2/ALX 6OMM
H8 261 E 8.54x54 DP2 receptor 6D27 - -
H8 262 P 8.55x55 DP2 receptor 6D27 - -
H8 263 L 8.56x56 DP2 receptor 6D27 M1 receptor 6OIJ
H8 264 R 8.57x57 DP2 receptor 6D27 - -
H8 265 S 8.58x58 DP2 receptor 6D27 GPR52 6LI3
H8 266 V 8.59x59 DP2 receptor 6D27 MT1 receptor 6ME2
H8 267 L 8.60x60 DP2 receptor 6D27 - -
H8 268 R 8.61x61 DP2 receptor 6D27 - -
H8 269 R 8.62x62 DP2 receptor 6D27 US28 4XT1
H8 270 A 8.63x63 DP2 receptor 6D27 CCR9 5LWE
H8 271 L 8.64x64 DP2 receptor 6D27 - -
C-term 272 G - - - - -
C-term 273 E - - - - -
C-term 274 G - - - - -
C-term 275 A - - - - -
C-term 276 E - - - - -