GPR152 (gp152_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR152
GENE
GPR152 (PGR5)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 152, G-protein coupled receptor PGR5
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
T
|
T
|
M
|
E
|
A
|
D
|
L
|
G
|
10 |
A
|
T
|
G
|
H
|
R
|
P
|
R
|
T
|
E
|
L
|
20 |
TM1 | |||||||||
D
|
D
|
E
|
D
|
S
|
Y
|
P
|
Q
|
G
|
G
|
30 |
W
|
D
|
T
|
V
|
F
|
L
|
V
|
A
|
L
|
L
|
40 |
L
|
L
|
G
|
L
|
P
|
A
|
N
|
G
|
L
|
M
|
50 |
A
|
W
|
L
|
A
|
G
|
S
|
Q
|
A
|
R
|
H
|
60 |
ICL1 | TM2 | ||||||||
G
|
A
|
G
|
T
|
R
|
L
|
A
|
L
|
L
|
L
|
70 |
L
|
S
|
L
|
A
|
L
|
S
|
D
|
F
|
L
|
F
|
80 |
L
|
A
|
A
|
A
|
A
|
F
|
Q
|
I
|
L
|
E
|
90 |
ECL1 | |||||||||
I
|
R
|
H
|
G
|
G
|
H
|
W
|
P
|
L
|
G
|
100 |
TM3 | |||||||||
T
|
A
|
A
|
C
|
R
|
F
|
Y
|
Y
|
F
|
L
|
110 |
W
|
G
|
V
|
S
|
Y
|
S
|
S
|
G
|
L
|
F
|
120 |
L
|
L
|
A
|
A
|
L
|
S
|
L
|
D
|
R
|
C
|
130 |
ICL2 | |||||||||
L
|
L
|
A
|
L
|
C
|
P
|
H
|
W
|
Y
|
P
|
140 |
TM4 | |||||||||
G
|
H
|
R
|
P
|
V
|
R
|
L
|
P
|
L
|
W
|
150 |
V
|
C
|
A
|
G
|
V
|
W
|
V
|
L
|
A
|
T
|
160 |
L
|
F
|
S
|
V
|
P
|
W
|
L
|
V
|
F
|
P
|
170 |
ECL2 | |||||||||
E
|
A
|
A
|
V
|
W
|
W
|
Y
|
D
|
L
|
V
|
180 |
I
|
C
|
L
|
D
|
F
|
W
|
D
|
S
|
E
|
E
|
190 |
TM5 | |||||||||
L
|
S
|
L
|
R
|
M
|
L
|
E
|
V
|
L
|
G
|
200 |
G
|
F
|
L
|
P
|
F
|
L
|
L
|
L
|
L
|
V
|
210 |
C
|
H
|
V
|
L
|
T
|
Q
|
A
|
T
|
A
|
C
|
220 |
ICL3 | TM6 | ||||||||
R
|
T
|
C
|
H
|
R
|
Q
|
Q
|
Q
|
P
|
A
|
230 |
A
|
C
|
R
|
G
|
F
|
A
|
R
|
V
|
A
|
R
|
240 |
T
|
I
|
L
|
S
|
A
|
Y
|
V
|
V
|
L
|
R
|
250 |
L
|
P
|
Y
|
Q
|
L
|
A
|
Q
|
L
|
L
|
Y
|
260 |
ECL3 | |||||||||
L
|
A
|
F
|
L
|
W
|
D
|
V
|
Y
|
S
|
G
|
270 |
TM7 | |||||||||
Y
|
L
|
L
|
W
|
E
|
A
|
L
|
V
|
Y
|
S
|
280 |
D
|
Y
|
L
|
I
|
L
|
L
|
N
|
S
|
C
|
L
|
290 |
H8 | |||||||||
S
|
P
|
F
|
L
|
C
|
L
|
M
|
A
|
S
|
A
|
300 |
D
|
L
|
R
|
T
|
L
|
L
|
R
|
S
|
V
|
L
|
310 |
C-term | |||||||||
S
|
S
|
F
|
A
|
A
|
A
|
L
|
C
|
E
|
E
|
320 |
R
|
P
|
G
|
S
|
F
|
T
|
P
|
T
|
E
|
P
|
330 |
Q
|
T
|
Q
|
L
|
D
|
S
|
E
|
G
|
P
|
T
|
340 |
L
|
P
|
E
|
P
|
M
|
A
|
E
|
A
|
Q
|
S
|
350 |
Q
|
M
|
D
|
P
|
V
|
A
|
Q
|
P
|
Q
|
V
|
360 |
N
|
P
|
T
|
L
|
Q
|
P
|
R
|
S
|
D
|
P
|
370 |
T
|
A
|
Q
|
P
|
Q
|
L
|
N
|
P
|
T
|
A
|
380 |
Q
|
P
|
Q
|
S
|
D
|
P
|
T
|
A
|
Q
|
P
|
390 |
Q
|
L
|
N
|
L
|
M
|
A
|
Q
|
P
|
Q
|
S
|
400 |
D
|
S
|
V
|
A
|
Q
|
P
|
Q
|
A
|
D
|
T
|
410 |
N
|
V
|
Q
|
T
|
P
|
A
|
P
|
A
|
A
|
S
|
420 |
S
|
V
|
P
|
S
|
P
|
C
|
D
|
E
|
A
|
S
|
430 |
P
|
T
|
P
|
S
|
S
|
H
|
P
|
T
|
P
|
G
|
440 |
A
|
L
|
E
|
D
|
P
|
A
|
T
|
P
|
P
|
A
|
450 |
S
|
E
|
G
|
E
|
S
|
P
|
S
|
S
|
T
|
P
|
460 |
P
|
E
|
A
|
A
|
P
|
G
|
A
|
G
|
P
|
T
|
470 |
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available