GPR61 (gpr61_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR61
GENE
GPR61 (BALGR, GPCR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 61, Biogenic amine receptor-like G-protein coupled receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
S
|
S
|
P
|
I
|
P
|
Q
|
S
|
S
|
10 |
G
|
N
|
S
|
S
|
T
|
L
|
G
|
R
|
V
|
P
|
20 |
Q
|
T
|
P
|
G
|
P
|
S
|
T
|
A
|
S
|
G
|
30 |
TM1 | |||||||||
V
|
P
|
E
|
V
|
G
|
L
|
R
|
D
|
V
|
A
|
40 |
S
|
E
|
S
|
V
|
A
|
L
|
F
|
F
|
M
|
L
|
50 |
L
|
L
|
D
|
L
|
T
|
A
|
V
|
A
|
G
|
N
|
60 |
A
|
A
|
V
|
M
|
A
|
V
|
I
|
A
|
K
|
T
|
70 |
ICL1 | TM2 | ||||||||
P
|
A
|
L
|
R
|
K
|
F
|
V
|
F
|
V
|
F
|
80 |
H
|
L
|
C
|
L
|
V
|
D
|
L
|
L
|
A
|
A
|
90 |
L
|
T
|
L
|
M
|
P
|
L
|
A
|
M
|
L
|
S
|
100 |
ECL1 | |||||||||
S
|
S
|
A
|
L
|
F
|
D
|
H
|
A
|
L
|
F
|
110 |
TM3 | |||||||||
G
|
E
|
V
|
A
|
C
|
R
|
L
|
Y
|
L
|
F
|
120 |
L
|
S
|
V
|
C
|
F
|
V
|
S
|
L
|
A
|
I
|
130 |
L
|
S
|
V
|
S
|
A
|
I
|
N
|
V
|
E
|
R
|
140 |
ICL2 | |||||||||
Y
|
Y
|
Y
|
V
|
V
|
H
|
P
|
M
|
R
|
Y
|
150 |
TM4 | |||||||||
E
|
V
|
R
|
M
|
T
|
L
|
G
|
L
|
V
|
A
|
160 |
S
|
V
|
L
|
V
|
G
|
V
|
W
|
V
|
K
|
A
|
170 |
L
|
A
|
M
|
A
|
S
|
V
|
P
|
V
|
L
|
G
|
180 |
ECL2 | |||||||||
R
|
V
|
S
|
W
|
E
|
E
|
G
|
A
|
P
|
S
|
190 |
V
|
P
|
P
|
G
|
C
|
S
|
L
|
Q
|
W
|
S
|
200 |
TM5 | |||||||||
H
|
S
|
A
|
Y
|
C
|
Q
|
L
|
F
|
V
|
V
|
210 |
V
|
F
|
A
|
V
|
L
|
Y
|
F
|
L
|
L
|
P
|
220 |
L
|
L
|
L
|
I
|
L
|
V
|
V
|
Y
|
C
|
S
|
230 |
M
|
F
|
R
|
V
|
A
|
R
|
V
|
A
|
A
|
M
|
240 |
ICL3 | |||||||||
Q
|
H
|
G
|
P
|
L
|
P
|
T
|
W
|
M
|
E
|
250 |
T
|
P
|
R
|
Q
|
R
|
S
|
E
|
S
|
L
|
S
|
260 |
S
|
R
|
S
|
T
|
M
|
V
|
T
|
S
|
S
|
G
|
270 |
TM6 | |||||||||
A
|
P
|
Q
|
T
|
T
|
P
|
H
|
R
|
T
|
F
|
280 |
G
|
G
|
G
|
K
|
A
|
A
|
V
|
V
|
L
|
L
|
290 |
A
|
V
|
G
|
G
|
Q
|
F
|
L
|
L
|
C
|
W
|
300 |
L
|
P
|
Y
|
F
|
S
|
F
|
H
|
L
|
Y
|
V
|
310 |
ECL3 | |||||||||
A
|
L
|
S
|
A
|
Q
|
P
|
I
|
S
|
T
|
G
|
320 |
TM7 | |||||||||
Q
|
V
|
E
|
S
|
V
|
V
|
T
|
W
|
I
|
G
|
330 |
Y
|
F
|
C
|
F
|
T
|
S
|
N
|
P
|
F
|
F
|
340 |
H8 | |||||||||
Y
|
G
|
C
|
L
|
N
|
R
|
Q
|
I
|
R
|
G
|
350 |
E
|
L
|
S
|
K
|
Q
|
F
|
V
|
C
|
F
|
F
|
360 |
C-term | |||||||||
K
|
P
|
A
|
P
|
E
|
E
|
E
|
L
|
R
|
L
|
370 |
P
|
S
|
R
|
E
|
G
|
S
|
I
|
E
|
E
|
N
|
380 |
F
|
L
|
Q
|
F
|
L
|
Q
|
G
|
T
|
G
|
C
|
390 |
P
|
S
|
E
|
S
|
W
|
V
|
S
|
R
|
P
|
L
|
400 |
P
|
S
|
P
|
K
|
Q
|
E
|
P
|
P
|
A
|
V
|
410 |
D
|
F
|
R
|
I
|
P
|
G
|
Q
|
I
|
A
|
E
|
420 |
E
|
T
|
S
|
E
|
F
|
L
|
E
|
Q
|
Q
|
L
|
430 |
T
|
S
|
D
|
I
|
I
|
M
|
S
|
D
|
S
|
Y
|
440 |
L
|
R
|
P
|
A
|
A
|
S
|
P
|
R
|
L
|
E
|
450 |
S
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page