GPR61 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8KGK

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-023-41654-3

PUBLICATION DATE

Oct. 11, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL4 N 345 - G.H5 Q 380 G.H5.22
Van-der-waals ICL4 N 345 - G.H5 Q 380 G.H5.22
Hydrophobic TM3 V 144 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL2 M 148 34x51 G.H5 C 369 G.H5.11
Hydrophobic TM5 M 231 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 M 231 5x61 G.H5 L 383 G.H5.25
Hydrophobic TM3 V 144 3x54 G.H5 H 377 G.H5.19
Van-der-waals TM3 V 144 3x54 G.H5 H 377 G.H5.19
Hydrophobic TM5 A 238 5x68 G.H5 L 384 G.H5.26
Hydrophobic ICL2 M 148 34x51 G.S1 H 41 G.S1.02
Polar TM3 V 144 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 V 144 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM5 V 234 5x64 G.H5 L 378 G.H5.20
Hydrophobic ICL2 M 148 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 M 148 34x51 G.H5 R 370 G.H5.12
Van-der-waals ICL2 M 148 34x51 G.H5 R 370 G.H5.12
Hydrophobic ICL2 P 147 34x50 G.H5 Q 374 G.H5.16
Van-der-waals ICL2 P 147 34x50 G.H5 Q 374 G.H5.16
Polar TM3 Y 143 3x53 G.H5 Q 380 G.H5.22
Hydrophobic TM3 Y 143 3x53 G.H5 Q 380 G.H5.22
Van-der-waals TM3 Y 143 3x53 G.H5 Q 380 G.H5.22
Hydrophobic TM5 Y 228 5x58 G.H5 L 383 G.H5.25
Hydrophobic ICL2 P 147 34x50 G.H5 R 370 G.H5.12
Hydrophobic ICL2 M 148 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 M 148 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL4 L 344 - G.H5 Y 381 G.H5.23
Ionic ICL4 R 346 - G.H5 E 382 G.H5.24
Polar ICL4 R 346 - G.H5 E 382 G.H5.24
Hydrophobic ICL4 R 346 - G.H5 E 382 G.H5.24
Van-der-waals ICL4 R 346 - G.H5 E 382 G.H5.24
Hydrophobic TM6 V 288 6x36 G.H5 L 383 G.H5.25
Van-der-waals TM6 V 288 6x36 G.H5 L 383 G.H5.25
Hydrophobic ICL4 N 345 - G.H5 Y 381 G.H5.23
Van-der-waals ICL4 N 345 - G.H5 Y 381 G.H5.23
Van-der-waals H8 Q 347 8x49 G.H5 Q 380 G.H5.22
Polar TM3 Y 143 3x53 G.H5 H 377 G.H5.19
Aromatic TM3 Y 143 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 Y 143 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 Y 143 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM6 K 284 6x32 G.H5 L 383 G.H5.25
Polar ICL4 R 346 - G.H5 R 379 G.H5.21
Hydrophobic ICL4 R 346 - G.H5 R 379 G.H5.21
Van-der-waals ICL4 R 346 - G.H5 R 379 G.H5.21
Hydrophobic TM5 A 235 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 A 235 5x65 G.H5 L 378 G.H5.20
Hydrophobic TM3 V 144 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 H 377 G.H5.19
Van-der-waals ICL2 P 147 34x50 G.H5 H 377 G.H5.19
Aromatic TM3 R 140 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM6 K 284 6x32 G.H5 E 382 G.H5.24
Van-der-waals TM6 K 284 6x32 G.H5 E 382 G.H5.24
Hydrophobic TM3 Y 143 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 Y 143 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM6 V 288 6x36 G.H5 E 382 G.H5.24
Polar TM3 V 145 3x55 G.H5 R 370 G.H5.12
Hydrophobic ICL2 M 148 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL2 M 148 34x51 G.H5 I 373 G.H5.15
Ionic H8 R 349 8x51 G.H5 E 382 G.H5.24
Polar H8 R 349 8x51 G.H5 E 382 G.H5.24
Hydrophobic H8 R 349 8x51 G.H5 E 382 G.H5.24
Van-der-waals H8 R 349 8x51 G.H5 E 382 G.H5.24
Hydrophobic TM5 A 235 5x65 G.H5 L 383 G.H5.25
Van-der-waals TM5 A 235 5x65 G.H5 L 383 G.H5.25
Hydrophobic TM5 A 238 5x68 G.H5 R 375 G.H5.17
Van-der-waals TM5 A 238 5x68 G.H5 R 375 G.H5.17
Hydrophobic ICL2 P 147 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 373 G.H5.15
Hydrophobic TM5 M 231 5x61 G.H5 L 378 G.H5.20
Van-der-waals TM5 M 231 5x61 G.H5 L 378 G.H5.20
Polar TM3 V 145 3x55 G.H5 Q 374 G.H5.16
Van-der-waals TM3 V 145 3x55 G.H5 Q 374 G.H5.16
Hydrophobic TM5 M 231 5x61 G.H5 Y 381 G.H5.23
Hydrophobic TM5 A 235 5x65 G.H5 L 384 G.H5.26
Polar ICL4 R 346 - G.H5 Q 380 G.H5.22
Hydrophobic ICL4 R 346 - G.H5 Q 380 G.H5.22
Van-der-waals ICL4 R 346 - G.H5 Q 380 G.H5.22
Polar TM6 A 285 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM6 A 285 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 A 285 6x33 G.H5 L 383 G.H5.25
Hydrophobic ICL2 M 148 34x51 G.S3 V 217 G.S3.01