ADGRG5 (agrg5_human)

FAMILY

Class B2 (Adhesion) Adhesion receptors ADGRG ADGRG5

GENE

ADGRG5 (GPR114, PGR27, UNQ2524/PRO6017)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Adhesion G-protein coupled receptor G5, G-protein coupled receptor 114, G-protein coupled receptor PGR27

SOURCE

SWISSPROT

SEQUENCE

N-term A.H4
M
D
H
C
G
A
L
F
L
C
10
                   
L
C
L
L
T
L
Q
N
A
T
20
                   
T
E
T
W
E
E
L
L
S
Y
30
                   
M
E
N
M
Q
V
S
R
G
R
40
A.h4h5 A.H6
S
S
V
F
S
S
R
Q
L
H
50
                   
Q
L
E
Q
M
L
L
N
T
S
60
A.h6s1 B.S1
F
P
G
Y
N
L
T
L
Q
T
70
B.s1s2 B.S2
P
T
I
Q
S
L
A
F
K
L
80
B.s2s3 B.S3
S
C
D
F
S
G
L
S
L
T
90
B.s3s4        
S
A
T
L
K
R
V
P
Q
A
100
                   
G
G
Q
H
A
R
G
Q
H
A
110
B.S5 B.s5s6
M
Q
F
P
A
E
L
T
R
D
120
                   
A
C
K
T
R
P
R
E
L
R
130
B.S6            
L
I
C
I
Y
F
S
N
T
H
140
B.s6s7        
F
F
K
D
E
N
N
S
S
L
150
B.S7 B.s7s8 B.S8
L
N
N
Y
V
L
G
A
Q
L
160
B.s8s9
S
H
G
H
V
N
N
L
R
D
170
  B.S9          
P
V
N
I
S
F
W
H
N
Q
180
B.s9s10 B.S10
S
L
E
G
Y
T
L
T
C
V
190
               
F
W
K
E
G
A
R
K
Q
P
200
B.s10s11 B.S11
W
G
G
W
S
P
E
G
C
R
210
B.S12    
T
E
Q
P
S
H
S
Q
V
L
220
B.S13 B.GPS
C
R
C
N
H
L
T
Y
F
A
230
B.S14          
V
L
M
Q
L
S
P
A
L
V
240
TM1              
P
A
E
L
L
A
P
L
T
Y
250
                   
I
S
L
V
G
C
S
I
S
I
260
                   
V
A
S
L
I
T
V
L
L
H
270
      ICL1 TM2
F
H
F
R
K
Q
S
D
S
L
280
                   
T
R
I
H
M
N
L
H
A
S
290
                   
V
L
L
L
N
I
A
F
L
L
300
            ECL1
S
P
A
F
A
M
S
P
V
P
310
TM3              
G
S
A
C
T
A
L
A
A
A
320
                   
L
H
Y
A
L
L
S
C
L
T
330
                   
W
M
A
I
E
G
F
N
L
Y
340
          ICL2  
L
L
L
G
R
V
Y
N
I
Y
350
    TM4          
I
R
R
Y
V
F
K
L
G
V
360
                   
L
G
W
G
A
P
A
L
L
V
370
                   
L
L
S
L
S
V
K
S
S
V
380
ECL2            
Y
G
P
C
T
I
P
V
F
D
390
                   
S
W
E
N
G
T
G
F
Q
N
400
              TM5
M
S
I
C
W
V
R
S
P
V
410
                   
V
H
S
V
L
V
M
G
Y
G
420
                   
G
L
T
S
L
F
N
L
V
V
430
                   
L
A
W
A
L
W
T
L
R
R
440
    ICL3        
L
R
E
R
A
D
A
P
S
V
450
TM6              
R
A
C
H
D
T
V
T
V
L
460
                   
G
L
T
V
L
L
G
T
T
W
470
                   
A
L
A
F
F
S
F
G
V
F
480
ECL3 TM7      
L
L
P
Q
L
F
L
F
T
I
490
                   
L
N
S
L
Y
G
F
F
L
F
500
              H8  
L
W
F
C
S
Q
R
C
R
S
510
                   
E
A
E
A
K
A
Q
I
E
A
520
      C-term
F
S
S
S
Q
T
T
Q

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

GAIN domain

S R G R S A.h4h5 T S F P G Y A.h6s1 T P T B.s1s2 S C D F S G B.s2s3 S A T L K R V P Q A G G Q H A R G Q B.s3s4 P A E L T R D A C K T R P R E B.s5s6 S N T H F F K D E N N S B.s6s7 N N B.s7s8 S H G H V N N L R D P B.s8s9 H N Q S L E G B.s9s10 E G A R K Q P W G B.s10s11 P E G B.s11s12 H S B.s12s13 N B.s13gps H C G A L F L C L C L L T L Q N A T T E T W E E L L S Y M E N M Q V S V F S S R Q L H Q L E Q M L L N N L T L Q I Q S L A F K L L S L T H A M Q F L R L I C I Y F S L L Y V L G A Q L V N I S F W Y T L T C V F W K G W S C R T E Q P S Q V L C R C H L T Y F A V L M Q L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

7TM

ICL1 R K Q S ICL1ECL1 S P V ECL1ICL2 V Y N I Y I R ICL2ECL2 S S V Y G P C T I P V F D S W E N G T G F Q N M S I C W V R ECL2ICL3 E R A D A P S V ICL3ECL3 V F L ECL3N-term M D N-termC-term S Q T T Q C-term P A E L L A P L T Y I S L V G C S I S I V A S L I T V L L H F H F D S L T R I H M N L H A S V L L L N I A F L L S P A F A M P G S A C T A L A A A L H Y A L L S C L T W M A I E G F N L Y L L L G R R Y V F K L G V L G W G A P A L L V L L S L S V K S P V V H S V L V M G Y G G L T S L F N L V V L A W A L W T L R R L R R A C H D T V T V L G L T V L L G T T W A L A F F S F G L P Q L F L F T I L N S L Y G F F L F L W F C S Q R C R S K A Q S S E A E A I E A F
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L S A V I S I S C G V L S I Y T L P A L 1 M N L H A S V L L L N I A F L L S P A F 2 I A M W T L C S L L A Y H L A A A L A T 3 Y V F K L G V G L W G A P A L L V L L S L 4 L V V L N F L S T L G G Y G M V L V S H V 5 L G L T V L L G T T W A L A F F S F G 6 L F L F F G Y L S N L I T F L F L Q P 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

agrg5_human active,

agrg5_human inactive

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 7EQ1