ADGRG5 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

7EQ1

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-022-04619-Y

PUBLICATION DATE

May 11, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
V 346 - ICL2 Q 384 G.H5.16 hydrophobic
V 346 - ICL2 Q 384 G.H5.16 van-der-waals
G 344 3x59 TM3 R 380 G.H5.12 polar
G 344 3x59 TM3 R 380 G.H5.12 van-der-waals
S 505 7x59 TM7 L 393 G.H5.25 hydrophobic
S 505 7x59 TM7 L 393 G.H5.25 van-der-waals
L 339 3x54 TM3 Y 391 G.H5.23 hydrophobic
D 278 2x44 TM2 Q 390 G.H5.22 polar
L 441 5x64 TM5 Q 384 G.H5.16 hydrophobic
L 441 5x64 TM5 Q 384 G.H5.16 van-der-waals
Y 347 - ICL2 H 41 G.S1.02 aromatic
Y 347 - ICL2 H 41 G.S1.02 hydrophobic
Q 517 8x57 H8 R 283 G.h3s5.01 hydrophobic
Q 517 8x57 H8 R 283 G.h3s5.01 van-der-waals
L 441 5x64 TM5 L 388 G.H5.20 hydrophobic
L 438 5x61 TM5 L 388 G.H5.20 hydrophobic
L 438 5x61 TM5 L 388 G.H5.20 van-der-waals
T 458 6x41 TM6 E 392 G.H5.24 hydrophobic
L 465 6x48 TM6 Y 391 G.H5.23 hydrophobic
L 465 6x48 TM6 Y 391 G.H5.23 van-der-waals
Y 347 - ICL2 V 217 G.S3.01 hydrophobic
Y 347 - ICL2 V 217 G.S3.01 van-der-waals
Y 350 - ICL2 K 34 G.HN.51 hydrophobic
Y 350 - ICL2 K 34 G.HN.51 van-der-waals
Y 347 - ICL2 F 376 G.H5.08 polar
Y 347 - ICL2 F 376 G.H5.08 aromatic
Y 347 - ICL2 F 376 G.H5.08 hydrophobic
Y 347 - ICL2 F 376 G.H5.08 van-der-waals
L 441 5x64 TM5 R 385 G.H5.17 polar
L 441 5x64 TM5 R 385 G.H5.17 hydrophobic
L 441 5x64 TM5 R 385 G.H5.17 van-der-waals
L 280 2x46 TM2 Y 391 G.H5.23 hydrophobic
L 280 2x46 TM2 Y 391 G.H5.23 van-der-waals
Q 506 7x60 TM7 L 393 G.H5.25 hydrophobic
Q 506 7x60 TM7 L 393 G.H5.25 van-der-waals
L 343 3x58 TM3 Q 384 G.H5.16 polar
L 343 3x58 TM3 Q 384 G.H5.16 hydrophobic
L 343 3x58 TM3 Q 384 G.H5.16 van-der-waals
L 462 6x45 TM6 Y 391 G.H5.23 hydrophobic
L 462 6x45 TM6 Y 391 G.H5.23 van-der-waals
R 509 8x49 H8 E 392 G.H5.24 ionic
R 509 8x49 H8 E 392 G.H5.24 polar
R 509 8x49 H8 E 392 G.H5.24 hydrophobic
R 509 8x49 H8 E 392 G.H5.24 van-der-waals
Y 347 - ICL2 F 219 G.S3.03 hydrophobic
G 461 6x44 TM6 L 393 G.H5.25 hydrophobic
R 442 5x65 TM5 L 388 G.H5.20 hydrophobic
R 442 5x65 TM5 L 388 G.H5.20 van-der-waals
L 343 3x58 TM3 L 388 G.H5.20 hydrophobic
L 343 3x58 TM3 L 388 G.H5.20 van-der-waals
T 458 6x41 TM6 Y 391 G.H5.23 polar
T 458 6x41 TM6 Y 391 G.H5.23 van-der-waals
N 348 - ICL2 K 216 G.s2s3.02 polar
I 349 - ICL2 H 387 G.H5.19 hydrophobic
I 349 - ICL2 H 387 G.H5.19 van-der-waals
V 346 - ICL2 I 383 G.H5.15 hydrophobic
V 346 - ICL2 I 383 G.H5.15 van-der-waals
Y 350 - ICL2 R 38 G.hns1.02 aromatic
Y 350 - ICL2 R 38 G.hns1.02 hydrophobic
L 280 2x46 TM2 Q 390 G.H5.22 hydrophobic
L 280 2x46 TM2 Q 390 G.H5.22 van-der-waals
L 342 3x57 TM3 Q 390 G.H5.22 hydrophobic
L 342 3x57 TM3 Q 390 G.H5.22 van-der-waals
W 502 7x56 TM7 Y 391 G.H5.23 hydrophobic
R 509 8x49 H8 L 393 G.H5.25 hydrophobic
R 509 8x49 H8 L 393 G.H5.25 van-der-waals
T 437 5x60 TM5 Q 384 G.H5.16 polar
T 437 5x60 TM5 Q 384 G.H5.16 van-der-waals
Y 347 - ICL2 C 379 G.H5.11 polar
Y 347 - ICL2 C 379 G.H5.11 hydrophobic
Y 347 - ICL2 C 379 G.H5.11 van-der-waals
L 342 3x57 TM3 H 387 G.H5.19 polar
L 342 3x57 TM3 H 387 G.H5.19 hydrophobic
L 342 3x57 TM3 H 387 G.H5.19 van-der-waals
L 342 3x57 TM3 Y 391 G.H5.23 hydrophobic
W 502 7x56 TM7 L 393 G.H5.25 hydrophobic
Y 350 - ICL2 Q 35 G.HN.52 hydrophobic
L 441 5x64 TM5 D 381 G.H5.13 hydrophobic
L 441 5x64 TM5 D 381 G.H5.13 van-der-waals
V 346 - ICL2 R 380 G.H5.12 hydrophobic
V 346 - ICL2 R 380 G.H5.12 van-der-waals
Y 347 - ICL2 I 383 G.H5.15 hydrophobic
Y 347 - ICL2 R 380 G.H5.12 polar
Y 347 - ICL2 R 380 G.H5.12 aromatic
Y 347 - ICL2 R 380 G.H5.12 hydrophobic
Y 347 - ICL2 R 380 G.H5.12 van-der-waals