GPR26 (gpr26_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR26
GENE
GPR26
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 26
SOURCE
SWISSPROT
SEQUENCE
N-term | TM1 | ||||||||
M
|
N
|
S
|
W
|
D
|
A
|
G
|
L
|
A
|
G
|
10 |
L
|
L
|
V
|
G
|
T
|
M
|
G
|
V
|
S
|
L
|
20 |
L
|
S
|
N
|
A
|
L
|
V
|
L
|
L
|
C
|
L
|
30 |
ICL1 | TM2 | ||||||||
L
|
H
|
S
|
A
|
D
|
I
|
R
|
R
|
Q
|
A
|
40 |
P
|
A
|
L
|
F
|
T
|
L
|
N
|
L
|
T
|
C
|
50 |
G
|
N
|
L
|
L
|
C
|
T
|
V
|
V
|
N
|
M
|
60 |
P
|
L
|
T
|
L
|
A
|
G
|
V
|
V
|
A
|
Q
|
70 |
ECL1 | TM3 | ||||||||
R
|
Q
|
P
|
A
|
G
|
D
|
R
|
L
|
C
|
R
|
80 |
L
|
A
|
A
|
F
|
L
|
D
|
T
|
F
|
L
|
A
|
90 |
A
|
N
|
S
|
M
|
L
|
S
|
M
|
A
|
A
|
L
|
100 |
S
|
I
|
D
|
R
|
W
|
V
|
A
|
V
|
V
|
F
|
110 |
ICL2 | |||||||||
P
|
L
|
S
|
Y
|
R
|
A
|
K
|
M
|
R
|
L
|
120 |
TM4 | |||||||||
R
|
D
|
A
|
A
|
L
|
M
|
V
|
A
|
Y
|
T
|
130 |
W
|
L
|
H
|
A
|
L
|
T
|
F
|
P
|
A
|
A
|
140 |
ECL2 | |||||||||
A
|
L
|
A
|
L
|
S
|
W
|
L
|
G
|
F
|
H
|
150 |
Q
|
L
|
Y
|
A
|
S
|
C
|
T
|
L
|
C
|
S
|
160 |
R
|
R
|
P
|
D
|
E
|
R
|
L
|
R
|
F
|
A
|
170 |
TM5 | |||||||||
V
|
F
|
T
|
G
|
A
|
F
|
H
|
A
|
L
|
S
|
180 |
F
|
L
|
L
|
S
|
F
|
V
|
V
|
L
|
C
|
C
|
190 |
T
|
Y
|
L
|
K
|
V
|
L
|
K
|
V
|
A
|
R
|
200 |
F
|
H
|
C
|
K
|
R
|
I
|
D
|
V
|
I
|
T
|
210 |
ICL3 | |||||||||
M
|
Q
|
T
|
L
|
V
|
L
|
L
|
V
|
D
|
L
|
220 |
H
|
P
|
S
|
V
|
R
|
E
|
R
|
C
|
L
|
E
|
230 |
TM6 | |||||||||
E
|
Q
|
K
|
R
|
R
|
R
|
Q
|
R
|
A
|
T
|
240 |
K
|
K
|
I
|
S
|
T
|
F
|
I
|
G
|
T
|
F
|
250 |
L
|
V
|
C
|
F
|
A
|
P
|
Y
|
V
|
I
|
T
|
260 |
R
|
L
|
V
|
E
|
L
|
F
|
S
|
T
|
V
|
P
|
270 |
ECL3 | TM7 | ||||||||
I
|
G
|
S
|
H
|
W
|
G
|
V
|
L
|
S
|
K
|
280 |
C
|
L
|
A
|
Y
|
S
|
K
|
A
|
A
|
S
|
D
|
290 |
H8 | |||||||||
P
|
F
|
V
|
Y
|
S
|
L
|
L
|
R
|
H
|
Q
|
300 |
Y
|
R
|
K
|
S
|
C
|
K
|
E
|
I
|
L
|
N
|
310 |
C-term | |||||||||
R
|
L
|
L
|
H
|
R
|
R
|
S
|
I
|
H
|
S
|
320 |
S
|
G
|
L
|
T
|
G
|
D
|
S
|
H
|
S
|
Q
|
330 |
N
|
I
|
L
|
P
|
V
|
S
|
E
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available