5-HT1D receptor (5ht1d_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT1D receptor
GENE
HTR1D (HTR1DA, HTRL)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 1D, 5-HT-1D, 5-HT1D, Serotonin 1D alpha receptor, 5-HT-1D-alpha, Serotonin receptor 1D
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
P
|
L
|
N
|
Q
|
S
|
A
|
E
|
G
|
10 |
L
|
P
|
Q
|
E
|
A
|
S
|
N
|
R
|
S
|
L
|
20 |
N
|
A
|
T
|
E
|
T
|
S
|
E
|
A
|
W
|
D
|
30 |
TM1 | |||||||||
P
|
R
|
T
|
L
|
Q
|
A
|
L
|
K
|
I
|
S
|
40 |
L
|
A
|
V
|
V
|
L
|
S
|
V
|
I
|
T
|
L
|
50 |
A
|
T
|
V
|
L
|
S
|
N
|
A
|
F
|
V
|
L
|
60 |
ICL1 | |||||||||
T
|
T
|
I
|
L
|
L
|
T
|
R
|
K
|
L
|
H
|
70 |
TM2 | |||||||||
T
|
P
|
A
|
N
|
Y
|
L
|
I
|
G
|
S
|
L
|
80 |
A
|
T
|
T
|
D
|
L
|
L
|
V
|
S
|
I
|
L
|
90 |
V
|
M
|
P
|
I
|
S
|
I
|
A
|
Y
|
T
|
I
|
100 |
ECL1 | TM3 | ||||||||
T
|
H
|
T
|
W
|
N
|
F
|
G
|
Q
|
I
|
L
|
110 |
C
|
D
|
I
|
W
|
L
|
S
|
S
|
D
|
I
|
T
|
120 |
C
|
C
|
T
|
A
|
S
|
I
|
L
|
H
|
L
|
C
|
130 |
V
|
I
|
A
|
L
|
D
|
R
|
Y
|
W
|
A
|
I
|
140 |
ICL2 | |||||||||
T
|
D
|
A
|
L
|
E
|
Y
|
S
|
K
|
R
|
R
|
150 |
TM4 | |||||||||
T
|
A
|
G
|
H
|
A
|
A
|
T
|
M
|
I
|
A
|
160 |
I
|
V
|
W
|
A
|
I
|
S
|
I
|
C
|
I
|
S
|
170 |
I
|
P
|
P
|
L
|
F
|
W
|
R
|
Q
|
A
|
K
|
180 |
ECL2 | |||||||||
A
|
Q
|
E
|
E
|
M
|
S
|
D
|
C
|
L
|
V
|
190 |
TM5 | |||||||||
N
|
T
|
S
|
Q
|
I
|
S
|
Y
|
T
|
I
|
Y
|
200 |
S
|
T
|
C
|
G
|
A
|
F
|
Y
|
I
|
P
|
S
|
210 |
V
|
L
|
L
|
I
|
I
|
L
|
Y
|
G
|
R
|
I
|
220 |
Y
|
R
|
A
|
A
|
R
|
N
|
R
|
I
|
L
|
N
|
230 |
ICL3 | |||||||||
P
|
P
|
S
|
L
|
Y
|
G
|
K
|
R
|
F
|
T
|
240 |
T
|
A
|
H
|
L
|
I
|
T
|
G
|
S
|
A
|
G
|
250 |
S
|
S
|
L
|
C
|
S
|
L
|
N
|
S
|
S
|
L
|
260 |
H
|
E
|
G
|
H
|
S
|
H
|
S
|
A
|
G
|
S
|
270 |
P
|
L
|
F
|
F
|
N
|
H
|
V
|
K
|
I
|
K
|
280 |
L
|
A
|
D
|
S
|
A
|
L
|
E
|
R
|
K
|
R
|
290 |
TM6 | |||||||||
I
|
S
|
A
|
A
|
R
|
E
|
R
|
K
|
A
|
T
|
300 |
K
|
I
|
L
|
G
|
I
|
I
|
L
|
G
|
A
|
F
|
310 |
I
|
I
|
C
|
W
|
L
|
P
|
F
|
F
|
V
|
V
|
320 |
S
|
L
|
V
|
L
|
P
|
I
|
C
|
R
|
D
|
S
|
330 |
ECL3 | TM7 | ||||||||
C
|
W
|
I
|
H
|
P
|
A
|
L
|
F
|
D
|
F
|
340 |
F
|
T
|
W
|
L
|
G
|
Y
|
L
|
N
|
S
|
L
|
350 |
I
|
N
|
P
|
I
|
I
|
Y
|
T
|
V
|
F
|
N
|
360 |
H8 | |||||||||
E
|
E
|
F
|
R
|
Q
|
A
|
F
|
Q
|
K
|
I
|
370 |
C-term | ||||||
V
|
P
|
F
|
R
|
K
|
A
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine, 5-HT-moduline
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7E32