5-HT1B receptor (5ht1b_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT1B receptor
GENE
HTR1B (HTR1DB)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta receptor, 5-HT-1D-beta, Serotonin receptor 1B
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
E
|
P
|
G
|
A
|
Q
|
C
|
A
|
P
|
10 |
P
|
P
|
P
|
A
|
G
|
S
|
E
|
T
|
W
|
V
|
20 |
P
|
Q
|
A
|
N
|
L
|
S
|
S
|
A
|
P
|
S
|
30 |
Q
|
N
|
C
|
S
|
A
|
K
|
D
|
Y
|
I
|
Y
|
40 |
TM1 | |||||||||
Q
|
D
|
S
|
I
|
S
|
L
|
P
|
W
|
K
|
V
|
50 |
L
|
L
|
V
|
M
|
L
|
L
|
A
|
L
|
I
|
T
|
60 |
L
|
A
|
T
|
T
|
L
|
S
|
N
|
A
|
F
|
V
|
70 |
I
|
A
|
T
|
V
|
Y
|
R
|
T
|
R
|
K
|
L
|
80 |
ICL1 | TM2 | ||||||||
H
|
T
|
P
|
A
|
N
|
Y
|
L
|
I
|
A
|
S
|
90 |
L
|
A
|
V
|
T
|
D
|
L
|
L
|
V
|
S
|
I
|
100 |
L
|
V
|
M
|
P
|
I
|
S
|
T
|
M
|
Y
|
T
|
110 |
ECL1 | TM3 | ||||||||
V
|
T
|
G
|
R
|
W
|
T
|
L
|
G
|
Q
|
V
|
120 |
V
|
C
|
D
|
F
|
W
|
L
|
S
|
S
|
D
|
I
|
130 |
T
|
C
|
C
|
T
|
A
|
S
|
I
|
L
|
H
|
L
|
140 |
C
|
V
|
I
|
A
|
L
|
D
|
R
|
Y
|
W
|
A
|
150 |
ICL2 | |||||||||
I
|
T
|
D
|
A
|
V
|
E
|
Y
|
S
|
A
|
K
|
160 |
TM4 | |||||||||
R
|
T
|
P
|
K
|
R
|
A
|
A
|
V
|
M
|
I
|
170 |
A
|
L
|
V
|
W
|
V
|
F
|
S
|
I
|
S
|
I
|
180 |
S
|
L
|
P
|
P
|
F
|
F
|
W
|
R
|
Q
|
A
|
190 |
ECL2 | |||||||||
K
|
A
|
E
|
E
|
E
|
V
|
S
|
E
|
C
|
V
|
200 |
TM5 | |||||||||
V
|
N
|
T
|
D
|
H
|
I
|
L
|
Y
|
T
|
V
|
210 |
Y
|
S
|
T
|
V
|
G
|
A
|
F
|
Y
|
F
|
P
|
220 |
T
|
L
|
L
|
L
|
I
|
A
|
L
|
Y
|
G
|
R
|
230 |
I
|
Y
|
V
|
E
|
A
|
R
|
S
|
R
|
I
|
L
|
240 |
ICL3 | |||||||||
K
|
Q
|
T
|
P
|
N
|
R
|
T
|
G
|
K
|
R
|
250 |
L
|
T
|
R
|
A
|
Q
|
L
|
I
|
T
|
D
|
S
|
260 |
P
|
G
|
S
|
T
|
S
|
S
|
V
|
T
|
S
|
I
|
270 |
N
|
S
|
R
|
V
|
P
|
D
|
V
|
P
|
S
|
E
|
280 |
S
|
G
|
S
|
P
|
V
|
Y
|
V
|
N
|
Q
|
V
|
290 |
K
|
V
|
R
|
V
|
S
|
D
|
A
|
L
|
L
|
E
|
300 |
TM6 | |||||||||
K
|
K
|
K
|
L
|
M
|
A
|
A
|
R
|
E
|
R
|
310 |
K
|
A
|
T
|
K
|
T
|
L
|
G
|
I
|
I
|
L
|
320 |
G
|
A
|
F
|
I
|
V
|
C
|
W
|
L
|
P
|
F
|
330 |
F
|
I
|
I
|
S
|
L
|
V
|
M
|
P
|
I
|
C
|
340 |
ECL3 | TM7 | ||||||||
K
|
D
|
A
|
C
|
W
|
F
|
H
|
L
|
A
|
I
|
350 |
F
|
D
|
F
|
F
|
T
|
W
|
L
|
G
|
Y
|
L
|
360 |
N
|
S
|
L
|
I
|
N
|
P
|
I
|
I
|
Y
|
T
|
370 |
H8 | |||||||||
M
|
S
|
N
|
E
|
D
|
F
|
K
|
Q
|
A
|
F
|
380 |
C-term | |||||||||
H
|
K
|
L
|
I
|
R
|
F
|
K
|
C
|
T
|
S
|
390 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine, 5-HT-moduline, tryptamine