STE2 (ste2_yeast)
FAMILY
Class D1 (Ste2-like fungal pheromone) Ste2-like receptors STE2 STE2
GENE
STE2 (YFL026W)
ORGANISM
strain ATCC 204508 / S288c (Saccharomyces cerevisiae)
ALT. NAMES
Pheromone alpha factor receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
D
|
A
|
A
|
P
|
S
|
L
|
S
|
N
|
10 |
L
|
F
|
Y
|
D
|
P
|
T
|
Y
|
N
|
P
|
G
|
20 |
D1S1 | |||||||||
Q
|
S
|
T
|
I
|
N
|
Y
|
T
|
S
|
I
|
Y
|
30 |
D1S2 | TM1 | ||||||||
G
|
N
|
G
|
S
|
T
|
I
|
T
|
F
|
D
|
E
|
40 |
L
|
Q
|
G
|
L
|
V
|
N
|
S
|
T
|
V
|
T
|
50 |
Q
|
A
|
I
|
M
|
F
|
G
|
V
|
R
|
C
|
G
|
60 |
A
|
A
|
A
|
L
|
T
|
L
|
I
|
V
|
M
|
W
|
70 |
ICL1 | TM2 | ||||||||
M
|
T
|
S
|
R
|
S
|
R
|
K
|
T
|
P
|
I
|
80 |
F
|
I
|
I
|
N
|
Q
|
V
|
S
|
L
|
F
|
L
|
90 |
I
|
I
|
L
|
H
|
S
|
A
|
L
|
Y
|
F
|
K
|
100 |
D1e1 | |||||||||
Y
|
L
|
L
|
S
|
N
|
Y
|
S
|
S
|
V
|
T
|
110 |
Y
|
A
|
L
|
T
|
G
|
F
|
P
|
Q
|
F
|
I
|
120 |
TM3 | |||||||||
S
|
R
|
G
|
D
|
V
|
H
|
V
|
Y
|
G
|
A
|
130 |
T
|
N
|
I
|
I
|
Q
|
V
|
L
|
L
|
V
|
A
|
140 |
S
|
I
|
E
|
T
|
S
|
L
|
V
|
F
|
Q
|
I
|
150 |
ICL2 | |||||||||
K
|
V
|
I
|
F
|
T
|
G
|
D
|
N
|
F
|
K
|
160 |
TM4 | |||||||||
R
|
I
|
G
|
L
|
M
|
L
|
T
|
S
|
I
|
S
|
170 |
F
|
T
|
L
|
G
|
I
|
A
|
T
|
V
|
T
|
M
|
180 |
Y
|
F
|
V
|
S
|
A
|
V
|
K
|
G
|
M
|
I
|
190 |
ECL2 | |||||||||
V
|
T
|
Y
|
N
|
D
|
V
|
S
|
A
|
T
|
Q
|
200 |
TM5 | |||||||||
D
|
K
|
Y
|
F
|
N
|
A
|
S
|
T
|
I
|
L
|
210 |
L
|
A
|
S
|
S
|
I
|
N
|
F
|
M
|
S
|
F
|
220 |
V
|
L
|
V
|
V
|
K
|
L
|
I
|
L
|
A
|
I
|
230 |
ICL3 | |||||||||
R
|
S
|
R
|
R
|
F
|
L
|
G
|
L
|
K
|
Q
|
240 |
TM6 | |||||||||
F
|
D
|
S
|
F
|
H
|
I
|
L
|
L
|
I
|
M
|
250 |
S
|
C
|
Q
|
S
|
L
|
L
|
V
|
P
|
S
|
I
|
260 |
I
|
F
|
I
|
L
|
A
|
Y
|
S
|
L
|
K
|
P
|
270 |
ECL3 | TM7 | ||||||||
N
|
Q
|
G
|
T
|
D
|
V
|
L
|
T
|
T
|
V
|
280 |
A
|
T
|
L
|
L
|
A
|
V
|
L
|
S
|
L
|
P
|
290 |
L
|
S
|
S
|
M
|
W
|
A
|
T
|
A
|
A
|
N
|
300 |
N
|
A
|
S
|
K
|
T
|
N
|
T
|
I
|
T
|
S
|
310 |
C-term | |||||||||
D
|
F
|
T
|
T
|
S
|
T
|
D
|
R
|
F
|
Y
|
320 |
P
|
G
|
T
|
L
|
S
|
S
|
F
|
Q
|
T
|
D
|
330 |
S
|
I
|
N
|
N
|
D
|
A
|
K
|
S
|
S
|
L
|
340 |
R
|
S
|
R
|
L
|
Y
|
D
|
L
|
Y
|
P
|
R
|
350 |
R
|
K
|
E
|
T
|
T
|
S
|
D
|
K
|
H
|
S
|
360 |
E
|
R
|
T
|
F
|
V
|
S
|
E
|
T
|
A
|
D
|
370 |
D
|
I
|
E
|
K
|
N
|
Q
|
F
|
Y
|
Q
|
L
|
380 |
P
|
T
|
P
|
T
|
S
|
S
|
K
|
N
|
T
|
R
|
390 |
I
|
G
|
P
|
F
|
A
|
D
|
A
|
S
|
Y
|
K
|
400 |
E
|
G
|
E
|
V
|
E
|
P
|
V
|
D
|
M
|
Y
|
410 |
T
|
P
|
D
|
T
|
A
|
A
|
D
|
E
|
E
|
A
|
420 |
R
|
K
|
F
|
W
|
T
|
E
|
D
|
N
|
N
|
N
|
430 |
L
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7AD3