LPA4 receptor (lpar4_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA4 receptor
GENE
LPAR4 (GPR23, LPA4, P2RY9)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
D
|
R
|
R
|
F
|
I
|
D
|
F
|
Q
|
10 |
F
|
Q
|
D
|
S
|
N
|
S
|
S
|
L
|
R
|
P
|
20 |
R
|
L
|
G
|
N
|
A
|
T
|
A
|
N
|
N
|
T
|
30 |
TM1 | |||||||||
C
|
I
|
V
|
D
|
D
|
S
|
F
|
K
|
Y
|
N
|
40 |
L
|
N
|
G
|
A
|
V
|
Y
|
S
|
V
|
V
|
F
|
50 |
I
|
L
|
G
|
L
|
I
|
T
|
N
|
S
|
V
|
S
|
60 |
L
|
F
|
V
|
F
|
C
|
F
|
R
|
M
|
K
|
M
|
70 |
ICL1 | TM2 | ||||||||
R
|
S
|
E
|
T
|
A
|
I
|
F
|
I
|
T
|
N
|
80 |
L
|
A
|
V
|
S
|
D
|
L
|
L
|
F
|
V
|
C
|
90 |
T
|
L
|
P
|
F
|
K
|
I
|
F
|
Y
|
N
|
F
|
100 |
ECL1 | TM3 | ||||||||
N
|
R
|
H
|
W
|
P
|
F
|
G
|
D
|
T
|
L
|
110 |
C
|
K
|
I
|
S
|
G
|
T
|
A
|
F
|
L
|
T
|
120 |
N
|
I
|
Y
|
G
|
S
|
M
|
L
|
F
|
L
|
T
|
130 |
C
|
I
|
S
|
V
|
D
|
R
|
F
|
L
|
A
|
I
|
140 |
ICL2 | |||||||||
V
|
Y
|
P
|
F
|
R
|
S
|
R
|
T
|
I
|
R
|
150 |
TM4 | |||||||||
T
|
R
|
R
|
N
|
S
|
A
|
I
|
V
|
C
|
A
|
160 |
G
|
V
|
W
|
I
|
L
|
V
|
L
|
S
|
G
|
G
|
170 |
I
|
S
|
A
|
S
|
L
|
F
|
S
|
T
|
T
|
N
|
180 |
ECL2 | |||||||||
V
|
N
|
N
|
A
|
T
|
T
|
T
|
C
|
F
|
E
|
190 |
TM5 | |||||||||
G
|
F
|
S
|
K
|
R
|
V
|
W
|
K
|
T
|
Y
|
200 |
L
|
S
|
K
|
I
|
T
|
I
|
F
|
I
|
E
|
V
|
210 |
V
|
G
|
F
|
I
|
I
|
P
|
L
|
I
|
L
|
N
|
220 |
V
|
S
|
C
|
S
|
S
|
V
|
V
|
L
|
R
|
T
|
230 |
ICL3 | TM6 | |||||||||
L
|
R
|
K
|
P
|
A
|
T
|
L
|
S
|
Q
|
I
|
|
240 |
G
|
T
|
N
|
K
|
K
|
K
|
V
|
L
|
K
|
M
|
250 |
I
|
T
|
V
|
H
|
M
|
A
|
V
|
F
|
V
|
V
|
260 |
C
|
F
|
V
|
P
|
Y
|
N
|
S
|
V
|
L
|
F
|
270 |
L
|
Y
|
A
|
L
|
V
|
R
|
S
|
Q
|
A
|
I
|
280 |
ECL3 | TM7 | ||||||||
T
|
N
|
C
|
F
|
L
|
E
|
R
|
F
|
A
|
K
|
290 |
I
|
M
|
Y
|
P
|
I
|
T
|
L
|
C
|
L
|
A
|
300 |
T
|
L
|
N
|
C
|
C
|
F
|
D
|
P
|
F
|
I
|
310 |
H8 | |||||||||
Y
|
Y
|
F
|
T
|
L
|
E
|
S
|
F
|
Q
|
K
|
320 |
S
|
F
|
Y
|
I
|
N
|
A
|
H
|
I
|
R
|
M
|
330 |
C-term | |||||||||
E
|
S
|
L
|
F
|
K
|
T
|
E
|
T
|
P
|
L
|
340 |
T
|
T
|
K
|
P
|
S
|
L
|
P
|
A
|
I
|
Q
|
350 |
E
|
E
|
V
|
S
|
D
|
Q
|
T
|
T
|
N
|
N
|
360 |
G
|
G
|
E
|
L
|
M
|
L
|
E
|
S
|
T
|
F
|
370 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
LPA, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, farnesyl diphosphate, LYSOPHOSPHATIDIC ACID
STRUCTURE MODELS
STRUCTURES
No structures available