H2 receptor (hrh2_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Histamine receptors H2 receptor
GENE
HRH2
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Histamine H2 receptor, H2R, HH2R, Gastric receptor I
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
P
|
N
|
G
|
T
|
A
|
S
|
S
|
F
|
10 |
TM1 | |||||||||
C
|
L
|
D
|
S
|
T
|
A
|
C
|
K
|
I
|
T
|
20 |
I
|
T
|
V
|
V
|
L
|
A
|
V
|
L
|
I
|
L
|
30 |
I
|
T
|
V
|
A
|
G
|
N
|
V
|
V
|
V
|
C
|
40 |
ICL1 | |||||||||
L
|
A
|
V
|
G
|
L
|
N
|
R
|
R
|
L
|
R
|
50 |
TM2 | |||||||||
N
|
L
|
T
|
N
|
C
|
F
|
I
|
V
|
S
|
L
|
60 |
A
|
I
|
T
|
D
|
L
|
L
|
L
|
G
|
L
|
L
|
70 |
V
|
L
|
P
|
F
|
S
|
A
|
I
|
Y
|
Q
|
L
|
80 |
ECL1 | TM3 | ||||||||
S
|
C
|
K
|
W
|
S
|
F
|
G
|
K
|
V
|
F
|
90 |
C
|
N
|
I
|
Y
|
T
|
S
|
L
|
D
|
V
|
M
|
100 |
L
|
C
|
T
|
A
|
S
|
I
|
L
|
N
|
L
|
F
|
110 |
M
|
I
|
S
|
L
|
D
|
R
|
Y
|
C
|
A
|
V
|
120 |
ICL2 | |||||||||
M
|
D
|
P
|
L
|
R
|
Y
|
P
|
V
|
L
|
V
|
130 |
TM4 | |||||||||
T
|
P
|
V
|
R
|
V
|
A
|
I
|
S
|
L
|
V
|
140 |
L
|
I
|
W
|
V
|
I
|
S
|
I
|
T
|
L
|
S
|
150 |
F
|
L
|
S
|
I
|
H
|
L
|
G
|
W
|
N
|
S
|
160 |
ECL2 | |||||||||
R
|
N
|
E
|
T
|
S
|
K
|
G
|
N
|
H
|
T
|
170 |
T
|
S
|
K
|
C
|
K
|
V
|
Q
|
V
|
N
|
E
|
180 |
TM5 | |||||||||
V
|
Y
|
G
|
L
|
V
|
D
|
G
|
L
|
V
|
T
|
190 |
F
|
Y
|
L
|
P
|
L
|
L
|
I
|
M
|
C
|
I
|
200 |
T
|
Y
|
Y
|
R
|
I
|
F
|
K
|
V
|
A
|
R
|
210 |
D
|
Q
|
A
|
K
|
R
|
I
|
N
|
H
|
I
|
S
|
220 |
TM6 | |||||||||
S
|
W
|
K
|
A
|
A
|
T
|
I
|
R
|
E
|
H
|
230 |
K
|
A
|
T
|
V
|
T
|
L
|
A
|
A
|
V
|
M
|
240 |
G
|
A
|
F
|
I
|
I
|
C
|
W
|
F
|
P
|
Y
|
250 |
F
|
T
|
A
|
F
|
V
|
Y
|
R
|
G
|
L
|
R
|
260 |
ECL3 | TM7 | ||||||||
G
|
D
|
D
|
A
|
I
|
N
|
E
|
V
|
L
|
E
|
270 |
A
|
I
|
V
|
L
|
W
|
L
|
G
|
Y
|
A
|
N
|
280 |
S
|
A
|
L
|
N
|
P
|
I
|
L
|
Y
|
A
|
A
|
290 |
H8 | |||||||||
L
|
N
|
R
|
D
|
F
|
R
|
T
|
G
|
Y
|
Q
|
300 |
C-term | |||||||||
Q
|
L
|
F
|
C
|
C
|
R
|
L
|
A
|
N
|
R
|
310 |
N
|
S
|
H
|
K
|
T
|
S
|
L
|
R
|
S
|
N
|
320 |
A
|
S
|
Q
|
L
|
S
|
R
|
T
|
Q
|
S
|
R
|
330 |
E
|
P
|
R
|
Q
|
Q
|
E
|
E
|
K
|
P
|
L
|
340 |
K
|
L
|
Q
|
V
|
W
|
S
|
G
|
T
|
E
|
V
|
350 |
T
|
A
|
P
|
Q
|
G
|
A
|
T
|
D
|
R
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
histamine
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7UL3