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G PROTEIN
STRUCTURE
RECEPTOR
OTHER PROTEINS
STRUCTURE LIGAND
ENDOGENOUS LIGAND
REFERENCE
Fam. α Species Note % of Seq β Species γ Species Method
PDB
 Refined
structure
 Resolution
UniProt
 IUPHAR Receptor family Class Species Receptor fusion Antibodies Other Name Type Function Name Type Authors Reference PDB Date
GPa1 family αPa1 strain ATCC 204508 / S288c Two alpha subunits bound to STE2 dimer 46 STE4 strain ATCC 204508 / S288c γ strain ATCC 204508 / S288c cryo-EM 7AD3 - 3.5 STE2 STE2 STE2 D1 (Ste2-like fungal pheromone) strain ATCC 204508 / S288c - - Gpa1 Alpha-factor mating pheromone pubchem
peptide Agonist - - Velazhahan V, Ma N, Pándy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG 10.1038/S41586-020-2994-1 2020-12-09
Gi/o αi1 Human Non-canonical conformation 62 β1 Human γ2 Human cryo-EM 6OSA 6OSA_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - - - JMV449 pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide Kato HE, Zhang Y, Hu H, Suomivuori C, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6OS9 6OS9_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - scFv16 - JMV449 pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide Kato HE, Zhang Y, Hu H, Suomivuori C, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10
Gs αs Bovine - 58 β1 Rat γ2 Bovine cryo-EM 6NBF 6NBF_refined 3.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyroid hormone analog
peptide Agonist PTHrP, TIP39, PTH, PTHrP-(1-36) protein Zhao L, Ma S, Sutkeviciute I, Shen D, Zhou XE, de Waal PW, Li C, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang M, Vilardaga J, Xu HE, Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17
Gs αs Bovine - 56 β1 Rat γ2 Bovine cryo-EM 6NBI 6NBI_refined 4.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyroid hormone analog
peptide Agonist PTHrP, TIP39, PTH, PTHrP-(1-36) protein Zhao L, Ma S, Sutkeviciute I, Shen D, Zhou XE, de Waal PW, Li C, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang M, Vilardaga J, Xu HE, Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17
Gs αs Bovine - 57 β1 Rat γ2 Bovine cryo-EM 6NBH - 3.5 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyroid hormone analog
peptide Agonist PTHrP, TIP39, PTH, PTHrP-(1-36) protein Zhao L, Ma S, Sutkeviciute I, Shen D, Zhou XE, de Waal PW, Li C, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang M, Vilardaga J, Xu HE, Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFM 6LFM_refined 3.5 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 protein Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu Z 10.1038/S41586-020-2492-5 2020-09-02
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFO 6LFO_refined 3.4 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 protein Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu Z 10.1038/S41586-020-2492-5 2020-09-02
Gi/o αi1 Human - 62 β1 Mouse γ2 Human cryo-EM 6K42 - 4.1 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline small molecule Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang H, Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15
Gi/o αo Human - 60 β1 Mouse γ2 Human cryo-EM 6K41 - 2.9 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline small molecule Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang H, Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15
Gi/o αo Human - 59 β1 Human γ2 Human cryo-EM 6G79 6G79_refined 3.8 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human - - - Donitriptan pubchem
small molecule Agonist 5-hydroxytryptamine, tryptamine, 5-HT-moduline small molecule García-Nafría J, Nehmé R, Edwards PC, Tate CG 10.1038/S41586-018-0241-9 2018-06-20
Gs αs Human Engineered G alpha 60 β1 Human γ2 Human cryo-EM 7JVQ 7JVQ_refined 3.0 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - Apomorphine pubchem chembl_ligand
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang X, Shen D, Xu T, Liu Y, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 7JVR 7JVR_refined 2.8 DRD2 D2 Dopamine A (Rhodopsin) Human - scFv16 - Bromocriptine pubchem
small molecule Agonist dopamine small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang X, Shen D, Xu T, Liu Y, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7JV5 - 3.0 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 743408-71-1 pubchem chembl_ligand
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang X, Shen D, Xu T, Liu Y, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7JVP 7JVP_refined 2.9 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 39YLC3L0ZU pubchem
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang X, Shen D, Xu T, Liu Y, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gi/o αo Human - 59 β1 Rat γ2 Mouse cryo-EM 6WWZ 6WWZ_refined 3.3 CCR6 CCR6 Chemokine A (Rhodopsin) Human - scFv16 - CCL20
protein Agonist CCL20, beta-defensin 4A protein Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H 10.1038/S41467-020-16820-6 2020-06-24
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 6PB1 6PB1_refined 2.8 CRFR2 CRF2 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, corticotrophin-releasing hormone, urocortin 1, urocortin 3 peptide Ma S, Shen Q, Zhao L, Mao C, Zhou XE, Shen D, de Waal PW, Bi P, Li C, Jiang Y, Wang M, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12
Gs αs Human Gs-Gi1 chimera 58 β1 Human γ2 Human cryo-EM 6PB0 6PB0_refined 3.0 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, corticotrophin-releasing hormone, urocortin 1 peptide Ma S, Shen Q, Zhao L, Mao C, Zhou XE, Shen D, de Waal PW, Bi P, Li C, Jiang Y, Wang M, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12
Gi/o αo Human - 61 β1 Human γ2 Human cryo-EM 7D77 7D77_refined 2.9 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human - scFv16 - Hydrocortisone pubchem
small molecule Agonist - - Ping Y, Mao C, Xiao P, Zhao R, Jiang Y, Yang Z, An W, Shen D, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li Z, Li S, Wang G, Tao X, Wen X, Zhong Y, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun J 10.1038/S41586-020-03083-W 2021-02-03
Gi/o αo Human - 59 β1 Human γ2 Human cryo-EM 7D76 - 3.1 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human - - - Beclomethasone pubchem
small molecule Agonist - - Ping Y, Mao C, Xiao P, Zhao R, Jiang Y, Yang Z, An W, Shen D, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li Z, Li S, Wang G, Tao X, Wen X, Zhong Y, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun J 10.1038/S41586-020-03083-W 2021-02-03
Gi/o αo Human - 61 β1 Human γ2 Human cryo-EM 6OIK 6OIK_refined 3.6 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human - - - Iperoxo pubchem
2CU pubchem
small molecule
small molecule 		Agonist
PAM 		acetylcholine small molecule Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08
Gq/11 α11 Human - 63 β1 Human γ2 Human cryo-EM 6OIJ 6OIJ_refined 3.3 ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human - Antibody fragment - Iperoxo pubchem
small molecule Agonist acetylcholine small molecule Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08
Gs αs Human - 58 β1 Rat γ2 Bovine cryo-EM 7CZ5 7CZ5_refined 2.6 GHRHR GHRH Glucagon B1 (Secretin) Human - Nanobody-35 - Somatoliberin pubchem
peptide Agonist GHRH peptide Zhou F, Zhang H, Cong Z, Zhao L, Zhou Q, Mao C, Cheng X, Shen D, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang M 10.1038/S41467-020-18945-0 2020-11-18
Gs αs Human Mini-Gs 61 β1 Human γ2 Human cryo-EM 6LI3 6LI3_refined 3.3 GPR52 GPR52 A orphans A (Rhodopsin) Human - Nanobody-35 - Apo (no ligand)
none Apo (no ligand) - - Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han G, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F 10.1038/S41586-020-2019-0 2020-02-26
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6PT0 6PT0_refined 3.2 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - Win 55212-2 pubchem chembl_ligand
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Xing C, Zhuang Y, Xu T, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie X 10.1016/J.CELL.2020.01.007 2020-02-12
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 7CMU 7CMU_refined 3.0 DRD3 D3 Dopamine A (Rhodopsin) Human BRIL scFv16 - Pramipexole pubchem
small molecule Agonist dopamine small molecule Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang X, Liu Y, Shen D, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE 10.1016/J.MOLCEL.2021.01.003 2021-03-10
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 7CMV 7CMV_refined 2.7 DRD3 D3 Dopamine A (Rhodopsin) Human BRIL scFv16 Gi (4Ar,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol pubchem chembl_ligand
small molecule Agonist dopamine small molecule Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang X, Liu Y, Shen D, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE 10.1016/J.MOLCEL.2021.01.003 2021-03-10
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CFM 7CFM_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody-35 - P395 pubchem chembl_ligand
small molecule Agonist chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid small molecule Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen D, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun J, Xie X, Yu X, Zhang Y 10.1038/S41586-020-2569-1 2020-09-09
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 7CFN 7CFN_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody-35 - INT-777 pubchem
INT-777 pubchem
small molecule
small molecule 		Agonist
PAM 		chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid small molecule Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen D, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun J, Xie X, Yu X, Zhang Y 10.1038/S41586-020-2569-1 2020-09-09
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WPW 6WPW_refined 3.1 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - Glucagon derivative ZP3780
peptide Agonist glucagon peptide Hilger D, Kumar KK, Hu H, Pedersen MF, O’Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK 10.1126/SCIENCE.ABA3373 2020-08-12
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6N4B 6N4B_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - Fub-mdmb pubchem
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G 10.1016/J.CELL.2018.11.040 2019-01-30
Gs αs Human Engineered G protein 50 - - - - X-ray 5G53 - 3.4 AA2AR A2A Adenosine A (Rhodopsin) Human - - - NECA pubchem
small molecule Agonist adenosine small molecule Carpenter B, Nehmé R, Warne T, Leslie AGW, Tate CG 10.1038/NATURE18966 2016-08-03
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6WI9 6WI9_refined 4.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Dong M, Deganutti G, Piper SJ, Liang Y, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ 10.1038/S41467-020-17791-4 2020-08-12
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6WZG 6WZG_refined 2.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Dong M, Deganutti G, Piper SJ, Liang Y, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ 10.1038/S41467-020-17791-4 2020-08-12
Gq/11 αq Human Gq-Gi2-Gs chimera 59 β1 Human γ2 Human cryo-EM 6WHA 6WHA_refined 3.4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human BRIL scFv16 Gq 25-CN-NBOH pubchem
small molecule Agonist 5-hydroxytryptamine, tryptamine small molecule Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL 10.1016/J.CELL.2020.08.024 2020-09-23
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6P9Y 6P9Y_refined 3.0 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Liang Y, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D 10.1016/J.MOLCEL.2020.01.012 2020-02-05
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6P9X 6P9X_refined 2.9 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Corticoliberin pubchem
peptide Agonist urocortin 2, corticotrophin-releasing hormone, urocortin 1 peptide Liang Y, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D 10.1016/J.MOLCEL.2020.01.012 2020-02-05
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6VN7 6VN7_refined 3.2 VIPR1 VPAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist secretin, GHRH, VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Duan J, Shen D, Zhou XE, Bi P, Liu Q, Tan Y, Zhuang Y, Zhang H, Xu P, Huang S, Ma S, He X, Melcher K, Zhang Y, Xu HE, Jiang Y 10.1038/S41467-020-17933-8 2020-09-02
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X1A 6X1A_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - PF-06882961 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang Y, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D 10.1101/2020.08.16.252585 2020-09-09
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X19 - 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - CHU-128 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang Y, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D 10.1101/2020.08.16.252585 2020-09-09
Gs αs Human - 90 β1 Human γ2 Human cryo-EM 6X18 6X18_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - GLP-1
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang Y, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D 10.1101/2020.08.16.252585 2020-09-09
Gs αs Human Engineered G alpha 58 β1 Human γ2 Human cryo-EM 7L1U 7L1U_refined 3.2 OX2R OX2 Orexin A (Rhodopsin) Human - scFv16 - orexin-A
peptide Agonist orexin-A, orexin-B peptide Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O’Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K 10.1038/S41467-021-21087-6 2021-02-10
Gs αs Human Engineered G alpha 58 β1 Human γ2 Human cryo-EM 7L1V 7L1V_refined 3.0 OX2R OX2 Orexin A (Rhodopsin) Human - scFv16 Sb51 4'-Methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl)phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide pubchem
small molecule Agonist orexin-A, orexin-B peptide Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O’Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K 10.1038/S41467-021-21087-6 2021-02-10
Gi/o αi2 Human - 59 β1 Human γ2 Human cryo-EM 6D9H 6D9H_refined 3.6 AA1R A1 Adenosine A (Rhodopsin) Human - - - adenosine pubchem
small molecule Agonist adenosine small molecule Draper-Joyce CJ, Khoshouei M, Thal DM, Liang Y, Nguyen ATN, Furness SGB, Venugopal H, Baltos J, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A 10.1038/S41586-018-0236-6 2018-06-20
Gs αs Human - 43 β1 Human γ2 Human cryo-EM 6NIY 6NIY_refined 3.3 CALCR CT Calcitonin B1 (Secretin) Human - - - calcitonin
peptide Agonist calcitonin, adrenomedullin, amylin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin peptide dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramírez-Aportela E, Carazo J, Hick CA, Furness SGB, Hay DL, Liang Y, Miller LJ, Christopoulos A, Wang M, Wootten D, Sexton PM 10.1021/ACSPTSCI.8B00056 2019-01-23
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUN 6UUN_refined 3.0 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP2 		- adrenomedullin
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang Y, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM 10.1021/ACSPTSCI.9B00080 2020-03-25
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUS 6UUS_refined 2.4 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3 		- adrenomedullin
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang Y, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UVA 6UVA_refined 2.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3 		- Adrenomedullin-2
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang Y, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBK 6XBK_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBM 6XBM_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - 24,25-Epoxy-cholesterol pubchem
24,25-Epoxy-cholesterol pubchem
small molecule
small molecule 		Agonist
PAM 		constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBJ 6XBJ_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBL 6XBL_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
SAG pubchem
N/A
small molecule 		Agonist
PAM 		constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gs αs Bovine - 89 β1 Rat γ2 Bovine X-ray 3SN6 3SN6_refined 3.2 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human T4-Lysozyme Antibody - BI-167107 pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ small molecule Rasmussen SGF, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah STA, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK 10.1038/NATURE10361 2011-07-20
Gs αs Human - 56 β1 Rat γ2 Bovine cryo-EM 7BW0 7BW0_refined 3.9 GPBAR GPBA Bile acid A (Rhodopsin) Human BRIL Nanobody-35 - - - - chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid small molecule Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R 10.1038/S41392-020-00262-Z 2020-09-02
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6E3Y 6E3Y_refined 3.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP1 		- Calcitonin gene-related peptide 1 pubchem
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang Y, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM 10.1038/S41586-018-0535-Y 2018-09-19
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6B3J 6B3J_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - - - Exendin-P5
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Liang Y, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang M, Miller LJ, Christopoulos A, Sexton PM, Wootten D 10.1038/NATURE25773 2018-02-21
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6GDG 6GDG_refined 4.1 AA2AR A2A Adenosine A (Rhodopsin) Human TrxA Nanobody - NECA pubchem
small molecule Agonist adenosine small molecule García-Nafría J, Lee Y, Bai X, Carpenter B, Tate CG 10.7554/ELIFE.35946 2018-05-16
Gs αs Human - 58 β1 Rat γ2 Bovine cryo-EM 7D3S 7D3S_refined 2.9 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O 10.1016/J.BBRC.2020.08.042 2020-11-04
Gs αs Human - 57 β1 Rat γ2 Bovine cryo-EM 6LPB 6LPB_refined 3.9 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O 10.1038/S41594-020-0386-8 2020-03-11
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6KPF 6KPF_refined 2.9 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol pubchem
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu Z 10.1016/J.CELL.2020.01.008 2020-02-12
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6KPG 6KPG_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol pubchem
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu Z 10.1016/J.CELL.2020.01.008 2020-02-12
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKZ 7CKZ_refined 3.1 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - dopamine pubchem
Mevidalen pubchem
small molecule
small molecule 		Agonist
PAM 		dopamine, 5-hydroxytryptamine, noradrenaline small molecule Xiao P, Yan W, Gou L, Zhong Y, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang C, Xia A, Hu Z, Zhang Q, He Y, Zhang D, Zhang C, Hou G, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun J, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKW 7CKW_refined 3.2 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - Fenoldopam pubchem
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Xiao P, Yan W, Gou L, Zhong Y, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang C, Xia A, Hu Z, Zhang Q, He Y, Zhang D, Zhang C, Hou G, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun J, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKX 7CKX_refined 3.5 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Xiao P, Yan W, Gou L, Zhong Y, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang C, Xia A, Hu Z, Zhang Q, He Y, Zhang D, Zhang C, Hou G, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun J, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKY 7CKY_refined 3.2 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 6-[4-[3-(Difluoromethoxy)pyridin-2-yl]oxy-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione pubchem chembl_ligand
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Xiao P, Yan W, Gou L, Zhong Y, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang C, Xia A, Hu Z, Zhang Q, He Y, Zhang D, Zhang C, Hou G, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun J, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CRH 7CRH_refined 3.3 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, (1S)- pubchem chembl_ligand
small molecule Agonist dopamine, 5-hydroxytryptamine, noradrenaline small molecule Xiao P, Yan W, Gou L, Zhong Y, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang C, Xia A, Hu Z, Zhang Q, He Y, Zhang D, Zhang C, Hou G, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun J, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6OMM 6OMM_refined 3.2 FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human - - - WKYMVX
peptide Agonist annexin I, humanin, LL-37, serum amyloid A, PrP106-126, CRAMP, LXA4, aspirin triggered lipoxin A4, resolvin D1, aspirin-triggered resolvin D1 protein Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu T, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C 10.1038/S41467-020-14728-9 2020-02-26
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6VCB 6VCB_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - GLP-1
LSN3160440 pubchem
peptide
small molecule 		Agonist
PAM 		glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jiménez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW 10.1038/S41589-020-0589-7 2020-07-22
Gs αs Human - 54 β1 Human γ2 Human cryo-EM 6M1H 6M1H_refined 3.6 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - Maxadilan pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang H, Ma Y 10.1038/S41422-020-0280-2 2020-03-11
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6M1I 6M1I_refined 3.5 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang H, Ma Y 10.1038/S41422-020-0280-2 2020-03-11
Gi/o αt1 Bovine - 59 β1 Bovine γT1 Bovine cryo-EM 6OYA 6OYA_refined 3.3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Camelid antibody VHH fragment - Retinal pubchem
small molecule Agonist Retinal small molecule Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24
Gi/o αt1 Bovine - 64 β1 Bovine γT1 Bovine cryo-EM 6OY9 6OY9_refined 3.9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal pubchem
small molecule Agonist Retinal small molecule Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24
Gs αs Bovine - 51 β1 Bovine γ2 Bovine cryo-EM 7JJO 7JJO_refined 2.6 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey - Nanobody-35 - Isoprenaline pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, noradrenaline small molecule Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee M, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang X 10.1016/J.MOLCEL.2020.08.001 2020-09-02
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6VMS 6VMS_refined 3.8 DRD2 D2 Dopamine A (Rhodopsin) Human T4-Lysozyme scFv16 - Bromocriptine pubchem
small molecule Agonist dopamine small molecule Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai X, Sunahara RK, Barth P, Rosenbaum DM 10.1038/S41586-020-2379-5 2020-06-17
Gs αs Human Engineered G alpha 58 β1 Rat γ2 Bovine cryo-EM 7LJD - 3.2 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - dopamine pubchem
Mevidalen pubchem
small molecule
small molecule 		Agonist
PAM 		dopamine, 5-hydroxytryptamine, noradrenaline small molecule Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang X, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE 10.1101/2021.02.07.430101 2021-03-03
Gs αs Human Engineered G alpha 58 β1 Rat γ2 Bovine cryo-EM 7LJC - 3.0 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 743408-71-1 pubchem chembl_ligand
Mevidalen pubchem
small molecule
small molecule 		Agonist
PAM 		dopamine, 5-hydroxytryptamine, noradrenaline small molecule Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang X, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE 10.1101/2021.02.07.430101 2021-03-03
Gs αs Human - 47 β1 Human γ2 Human cryo-EM 5UZ7 5UZ7_refined 4.1 CALCR CT Calcitonin B1 (Secretin) Human - - - - - - calcitonin, adrenomedullin, amylin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin peptide Liang Y, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM 10.1038/NATURE22327 2017-05-03
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WHC 6WHC_refined 3.4 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - Dual-agonist peptide P15
peptide Agonist glucagon peptide Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang Y, Ma L, Han S, Yang D, Danev R, Wang M, Wootten D, Wu B, Sexton PM 10.1074/JBC.RA120.013793 2020-05-27
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6XOX 6XOX_refined 3.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - scFv16
Nanobody-35 		- LY3502970 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW 10.1073/PNAS.2014879117 2020-11-18
Gs αs Human - 50 β1 Bovine γ2 Bovine cryo-EM 7BZ2 7BZ2_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Formoterol pubchem chembl_ligand
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ small molecule Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C 10.1038/S41421-020-0176-9 2020-08-05
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6OT0 - 3.9 SMO SMO Frizzled F (Frizzled) Human - Fab light chain
Fab heavy chain 		- 24,25-Epoxy-cholesterol pubchem
small molecule Agonist constitutive constitutive Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X 10.1038/S41586-019-1286-0 2019-06-12
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDF 6DDF_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - - - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Met]enkephalin, dynorphin A-(1-13), dynorphin A, dynorphin A-(1-8), dynorphin B, endomorphin-1, β-endorphin, endomorphin-2 peptide Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDE 6DDE_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - Antibody - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Met]enkephalin, dynorphin A-(1-13), dynorphin A, dynorphin A-(1-8), dynorphin B, endomorphin-1, β-endorphin, endomorphin-2 peptide Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13
Gs αs Human - 59 β1 Rat γ2 Bovine cryo-EM 5VAI 5VAI_refined 4.1 G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit - - - GLP-1
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G 10.1038/NATURE22394 2017-05-24
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine cryo-EM 6CMO 6CMO_refined 4.5 OPSD Rhodopsin Opsins A (Rhodopsin) Human BRIL Fab - Apo (no ligand)
none Apo (no ligand) Retinal small molecule Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE 10.1038/S41586-018-0215-Y 2018-06-20
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 6LML 6LML_refined 3.9 GLR glucagon Glucagon B1 (Secretin) Human - scFv16 - glucagon pubchem
peptide Agonist glucagon peptide Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang M, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6LMK 6LMK_refined 3.7 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - glucagon pubchem
peptide Agonist glucagon peptide Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang M, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01
Gi/o αo Human Mini-Go 51 - - - - X-ray 6FUF - 3.1 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal pubchem
small molecule Agonist Retinal small molecule Tsai C, Pamula F, Nehmé R, Mühle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX 10.1126/SCIADV.AAT7052 2018-10-03
Gs αs Human - 55 β1 Bovine γ2 Bovine cryo-EM 7DHI 7DHI_refined 3.3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Salbutamol pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ small molecule Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C 10.1093/NSR/NWAA284 2020-12-16
Gs αs Human - 49 β1 Bovine γ2 Bovine cryo-EM 7DHR 7DHR_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Isoprenaline pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ small molecule Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C 10.1093/NSR/NWAA284 2020-12-16
Gi/o αi1 Human - 60 β1 Bovine γT1 Bovine cryo-EM 6QNO 6QNO_refined 4.4 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Fab antibody fragment light chain
Fab antibody fragment heavy chain 		- Retinal pubchem
small molecule Agonist Retinal small molecule Tsai C, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G 10.7554/ELIFE.46041 2019-07-10
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 7C2E 7C2E_refined 4.2 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE 10.1038/S41422-020-0384-8 2020-08-26
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6ORV - 3.0 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - TT-OAD2 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhao P, Liang Y, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang M, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D 10.1038/s41586-019-1902-z 2020-01-08
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6NI3 6NI3_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - BI-167107 pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ small molecule Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang L, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ 10.1038/S41594-019-0330-Y 2019-11-20
Gi/o αi1 Human - 95 β1 Human γT1 Human cryo-EM 7L0Q 7L0Q_refined 4.3 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem chembl_ligand
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7D7M 7D7M_refined 3.3 PE2R4 EP4 Prostanoid A (Rhodopsin) Human - Nanobody-35 - Prostaglandin E2 pubchem chembl_ligand
small molecule Agonist PGE1, PGD2, PGE2, PGF2α, PGI2 small molecule - - 2020-11-18
Gi/o αi1 Human Non-canonical conformation 63 β1 Human γT1 Human cryo-EM 7L0R 7L0R_refined 4.2 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem chembl_ligand
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gs αs Human - 62 β1 Human γ2 Human cryo-EM 7LCI 7LCI_refined 2.9 GLP1R GLP-1 Glucagon B1 (Secretin) Human - - - PF-06882961 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide - - 2021-01-20
Gi/o αi1 Human Non-canonical conformation 95 β1 Human γT1 Human cryo-EM 7L0S 7L0S_refined 4.5 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem chembl_ligand
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gi/o αi1 Human - 63 β1 Human γT1 Human cryo-EM 7L0P 7L0P_refined 4.1 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem chembl_ligand
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gq/11 αq Human - 63 β1 Human γ2 Human cryo-EM 7DFL 7DFL_refined 3.3 HRH1 H1 Histamine A (Rhodopsin) Human - scFv16 Gq histamine pubchem
small molecule Agonist histamine small molecule - - 2021-03-31
Gs αs Human - 96 - - - - X-ray 6AU6 - 1.7 - - - - - - - - - - - - - Hu Q, Shokat KM 29628140 2018-05-09
Gs αs Human - 100 - - - - X-ray 6E67 - 3.7 - - - - - - - - - - - - - Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK 31080070 2019-06-05
Gs αs Human - 97 β1 Human γ2 Human X-ray 6EG8 - 2.8 - - - - - - - - - - - - - Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK 31080070 2019-06-05
Gs αs Human - 96 - - - - X-ray 7BPH - 1.6 - - - - - - - - - - - - - - - 2021-03-31
Gs αs Bovine - 100 - - - - X-ray 2GVZ - 3.3 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR 16766715 2006-07-04
Gs αs Bovine - 100 - - - - X-ray 2GVD - 2.9 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR 16766715 2006-07-04
Gs αs Bovine - 100 - - - - X-ray 3G82 - 3.1 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - - - 2010-02-16
Gs αs Bovine - 100 - - - - X-ray 3MAA - 3.0 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2010-04-07
Gs αs Bovine - 100 - - - - X-ray 3C14 - 2.7 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2009-02-03
Gs αs Bovine - 100 - - - - X-ray 3C15 - 2.8 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2009-02-03
Gs αs Bovine - 100 - - - - X-ray 3C16 - 2.9 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2009-02-03
Gs αs Bovine - 100 - - - - cryo-EM 6R3Q - 3.4 - - - - - - - Adenylate cyclase 9 - - - - - Qi C, Sorrentino S, Medalia O, Korkhov VM 31023924 2019-05-08
Gs αs Bovine - 100 - - - - cryo-EM 6R4P - 3.1 - - - - - - - Adenylate cyclase 9 - - - - - Qi C, Sorrentino S, Medalia O, Korkhov VM 31023924 2019-05-08
Gs αs Bovine - 100 - - - - cryo-EM 6R4O - 4.2 - - - - - - - Adenylate cyclase 9 - - - - - Qi C, Sorrentino S, Medalia O, Korkhov VM 31023924 2019-05-08
Gs αs Bovine - 100 - - - - X-ray 1CJK - 3.0 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CJV - 3.0 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CJU - 2.8 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CJT - 2.8 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CS4 - 2.5 - - - - - - - TYPE V ADENYLATE CYCLASE
TYPE II ADENYLATE CYCLASE 		- - - - - Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR 11087399 2001-01-10
Gs αs Bovine - 96 - - - - X-ray 1CUL - 2.4 - - - - - - - TYPE V ADENYLYL CYCLASE
TYPE II ADENYLYL CYCLASE 		- - - - - Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR 11087399 2001-01-10
Gs αs Bovine - 100 - - - - X-ray 1AZT - 2.3 - - - - - - - - - - - - - Sunahara RK, Tesmer JJ, Gilman AG, Sprang SR 9395396 1998-02-25
Gs αs Bovine - 100 - - - - X-ray 1AZS - 2.3 - - - - - - - VC1
IIC2 		- - - - - Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR 9417641 1998-02-25
Gs αs Bovine - 100 - - - - X-ray 1TL7 - 2.8 - - - - - - - Adenylate cyclase
type V
Adenylate cyclase
type II 		- - - - - Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR 15591060 2004-12-14
Gs αs Bovine - 100 - - - - X-ray 1U0H - 2.9 - - - - - - - Adenylate cyclase
type V
Adenylate cyclase
type II 		- - - - - Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR 15591060 2004-12-14
Gi/o αi1 Human - 91 - - - - X-ray 2GTP - 2.6 - - - - - - - Regulator of G-protein signaling 1 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2006-05-23
Gi/o αi1 Human - 88 - - - - X-ray 2G83 - 2.8 - - - - - - - KB-1753 phage display peptide - - - - - Johnston CA, Lobanova ES, Shavkunov AS, Low J, Ramer JK, Blaesius R, Fredericks Z, Willard FS, Kuhlman B, Arshavsky VY, Siderovski DP 16981699 2006-10-10
Gi/o αi1 Human - 93 - - - - X-ray 3ONW - 2.4 - - - - - - - Regulator of G-protein signaling 14 - - - - - Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP 21115486 2010-11-24
Gi/o αi1 Human - 100 - - - - X-ray 3UMS - 2.3 - - - - - - - - - - - - - - - 2012-02-08
Gi/o αi1 Human - 100 - - - - X-ray 3UMR - 2.0 - - - - - - - - - - - - - - - 2012-10-24
Gi/o αi1 Human - 92 - - - - X-ray 3QE0 - 3.0 - - - - - - - KB752 peptide - - - - - Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP 22383884 2012-01-25
Gi/o αi1 Human - 93 - - - - X-ray 3QI2 - 2.8 - - - - - - - Regulator of G-protein signaling 14 - - - - - Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP 22383884 2012-02-01
Gi/o αi1 Human - 93 - - - - X-ray 4G5Q - 2.9 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi1 Human - 92 - - - - X-ray 2XNS - 3.4 - - - - - - - Regulator of G-protein signaling 14 - - - - - Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B 21388199 2011-06-08
Gi/o αi1 Human - 92 - - - - X-ray 2OM2 - 2.2 - - - - - - - Regulator of G-protein signalling 14 GoLoco motif peptide - - - - - Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B 17603074 2007-07-10
Gi/o αi1 Human - 100 β1 Human γ2 Human X-ray 6CRK - 2.0 - - - - - - single-chain Fv - - - - - - Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK 30213947 2018-10-24
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine X-ray 5TDH - 3.0 - - - - - - - - - - - - - Liu P, Jia MZ, Zhou XE, De Waal PW, Dickson BM, Liu B, Hou L, Yin YT, Kang YY, Shi Y, Melcher K, Xu HE, Jiang Y 27498775 2016-11-09
Gi/o αi1 Human - 92 - - - - X-ray 2IK8 - 2.7 - - - - - - - Regulator of G-protein signaling 16 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2006-11-21
Gi/o αi1 Human - 100 - - - - cryo-EM 6VU8 - 4.1 - - - - - - - Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G 32126208 2020-03-18
Gi/o αi1 Human - 92 - - - - X-ray 1KJY - 2.7 - - - - - - - Regulator of G-protein signaling 14 - - - - - Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP 11976690 2002-05-08
Gi/o αi1 Human - 93 - - - - X-ray 1Y3A - 2.5 - - - - - - - KB752 peptide - - - - - Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP 16004878 2005-07-12
Gi/o αi1 Rat - 100 - - - - X-ray 2RGN - 3.5 - - - - - - - Rho guanine nucleotide exchange factor 25
Transforming protein RhoA 		- - - - - Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ 18096806 2008-01-15
Gi/o αi1 Rat - 100 - - - - X-ray 3D7M - 2.9 - - - - - - - - - - - - - Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM 19222191 2009-03-03
Gi/o αi1 Rat - 100 - - - - X-ray 3V00 - 2.9 - - - - - - - - - - - - - Singh G, Ramachandran S, Cerione RA 22448927 2012-04-18
Gi/o αi1 Rat - 100 - - - - X-ray 2ZJZ - 2.6 - - - - - - - - - - - - - - - 2009-03-24
Gi/o αi1 Rat - 100 - - - - X-ray 2ZJY - 2.8 - - - - - - - - - - - - - - - 2009-03-24
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 3AH8 - 2.9 - - - - - - - YM-254890 - - - - - Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H 20639466 2010-07-21
Gi/o αi1 Rat - 100 - - - - X-ray 3FFA - 2.3 - - - - - - - - - - - - - Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP 19703466 2009-10-06
Gi/o αi1 Rat - 100 - - - - X-ray 3FFB - 2.6 - - - - - - - - - - - - - Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP 19703466 2009-10-06
Gi/o αi1 Rat - 100 - - - - X-ray 4PAM - 2.1 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4PAN - 2.4 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4PAO - 2.0 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4PAQ - 2.0 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 6M8H - 2.1 - - - - - - - - - - - - - - - 2019-08-21
Gi/o αi1 Rat - 100 - - - - X-ray 5KDL - 2.7 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 27462082 2016-08-03
Gi/o αi1 Rat - 100 β1 Bovine γT1 Bovine X-ray 5KDO - 1.9 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 27462082 2016-08-03
Gi/o αi1 Rat - 100 - - - - X-ray 4N0D - 1.6 - - - - - - - - - - - - - Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM 24596087 2014-03-12
Gi/o αi1 Rat - 100 - - - - X-ray 4N0E - 2.1 - - - - - - - - - - - - - Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM 24596087 2014-03-12
Gi/o αi1 Rat - 91 - - - - cryo-EM 6UKT - 3.9 - - - - - - NB8109
NB8117
NB8119
NB9156 		Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR 32103024 2020-03-11
Gi/o αi1 Rat - 100 - - - - X-ray 1AGR - 2.8 - - - - - - - RGS4 - - - - - Tesmer JJ, Berman DM, Gilman AG, Sprang SR 9108480 1997-06-16
Gi/o αi1 Rat - 100 - - - - X-ray 1CIP - 1.5 - - - - - - - - - - - - - Coleman DE, Sprang SR 10358003 1999-04-09
Gi/o αi1 Rat - 100 - - - - X-ray 6TYL - 3.3 - - - - - - Nanobody A
Nanobody B
Nanobody C 		Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR 32103024 2020-03-11
Gi/o αi1 Rat - 100 - - - - X-ray 1AS3 - 2.4 - - - - - - - - - - - - - Raw AS, Coleman DE, Gilman AG, Sprang SR 9398294 1997-11-12
Gi/o αi1 Rat - 100 - - - - X-ray 1AS2 - 2.8 - - - - - - - - - - - - - Raw AS, Coleman DE, Gilman AG, Sprang SR 9398294 1997-11-12
Gi/o αi1 Rat - 100 - - - - X-ray 1AS0 - 2.0 - - - - - - - - - - - - - Raw AS, Coleman DE, Gilman AG, Sprang SR 9398294 1997-11-12
Gi/o αi1 Rat - 89 - - - - X-ray 1BH2 - 2.1 - - - - - - - - - - - - - Posner BA, Mixon MB, Wall MA, Sprang SR, Gilman AG 9705312 1998-11-04
Gi/o αi1 Rat - 100 - - - - X-ray 1BOF - 2.2 - - - - - - - - - - - - - Coleman DE, Sprang SR 9772163 1999-01-06
Gi/o αi1 Rat - 92 - - - - X-ray 1FQK - 2.3 - - - - - - - Regulator of G-protein signaling 9 - - - - - Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB 11234020 2001-02-28
Gi/o αi1 Rat - 92 - - - - X-ray 1FQJ - 2.0 - - - - - - - Regulator of G-protein signaling 9 - - - - - Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB 11234020 2001-02-28
Gi/o αi1 Rat - 100 - - - - X-ray 1GDD - 2.2 - - - - - - - - - - - - - Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR 7481799 1995-11-27
Gi/o αi1 Rat - 100 - - - - X-ray 1GFI - 2.2 - - - - - - - - - - - - - Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR 8073283 1995-03-31
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 1GG2 - 2.4 - - - - - - - - - - - - - Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR 8521505 1997-02-12
Gi/o αi1 Rat - 100 - - - - X-ray 1GIL - 2.3 - - - - - - - - - - - - - Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR 8073283 1995-02-14
Gi/o αi1 Rat - 100 - - - - X-ray 1GIA - 2.0 - - - - - - - - - - - - - Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR 8073283 1994-09-30
Gi/o αi1 Rat - 100 - - - - X-ray 1GIT - 2.6 - - - - - - - - - - - - - Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR 8939752 1997-02-12
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 1GP2 - 2.3 - - - - - - - - - - - - - Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR 8521505 1997-02-12
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 2BCJ - 3.1 - - - - - - - G-protein-coupled receptor kinase 2 - - - - - Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ 16339447 2005-12-20
Gi/o αi1 Rat - 100 - - - - X-ray 1SVK - 2.0 - - - - - - - - - - - - - Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR 15128951 2004-06-01
Gi/o αi1 Rat - 100 - - - - X-ray 1SVS - 1.5 - - - - - - - - - - - - - Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR 15128951 2004-06-01
Gi/o αi1 Rat - 96 - - - - X-ray 1SHZ - 2.9 - - - - - - - Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera
Rho guanine nucleotide exchange factor 1 		- - - - - Chen Z, Singer WD, Sternweis PC, Sprang SR 15665872 2005-01-18
Gi/o αi3 Human - 91 - - - - X-ray 2IHB - 2.7 - - - - - - - Regulator of G-protein signalling 10 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2006-11-21
Gi/o αi3 Human - 93 - - - - X-ray 4G5R - 3.5 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi3 Human - 93 - - - - X-ray 4G5S - 3.6 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi3 Human - 93 - - - - X-ray 4G5O - 2.9 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi3 Human - 99 - - - - X-ray 2V4Z - 2.8 - - - - - - - REGULATOR OF G-PROTEIN SIGNALING 2 - - - - - Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP 19478087 2008-11-04
Gi/o αi3 Human - 99 - - - - X-ray 2ODE - 1.9 - - - - - - - Regulator of G-protein signaling 8 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2007-02-06
Gi/o αi3 Rat - 99 - - - - X-ray 6MHF - 2.0 - - - - - - - Girdin - - - - - Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I 31363053 2019-07-31
Gi/o αi3 Rat - 99 - - - - X-ray 6MHE - 2.2 - - - - - - - KB752 peptide - - - - - Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I 31363053 2019-07-31
Gi/o αt1 Human - 3 - - - - X-ray 3RBQ - 2.0 - - - - - - - Protein unc-119 homolog A - - - - - Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W 21642972 2011-06-08
Gi/o αt1 Bovine - 3 - - - - X-ray 3DQB - 3.2 - - - - - - - Rhodopsin - - - - - Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP 18818650 2008-09-23
Gi/o αt1 Bovine - 3 - - - - X-ray 2X72 - 3.0 - - - - - - - RHODOPSIN - - - - - Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF 21389983 2011-03-16
Gi/o αt1 Bovine - 3 - - - - X-ray 3PQR - 2.9 - - - - - - - Rhodopsin - - - - - Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP 21389988 2011-03-09
Gi/o αt1 Bovine - 3 - - - - X-ray 4J4Q - 2.7 - - - - - - - Rhodopsin - - - - - Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP 24038729 2013-10-30
Gi/o αt1 Bovine - 3 - - - - X-ray 4BEY - 2.9 - - - - - - - Rhodopsin - - - - - Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J 23579341 2013-05-08
Gi/o αt1 Bovine - 3 - - - - X-ray 4A4M - 3.3 - - - - - - - RHODOPSIN - - - - - Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J 22198838 2012-01-25
Gi/o αt1 Bovine - 100 - - - - cryo-EM 7JSN - 3.2 - - - - - - - Rod cGMP-specific 3'
5'-cyclic phosphodiesterase subunit alpha
Rod cGMP-specific 3'
5'-cyclic phosphodiesterase subunit beta 		- - - - - Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA 33007200 2020-10-21
Gi/o αt1 Bovine - 100 β1 Bovine γT1 Bovine X-ray 1GOT - 2.0 - - - - - - - - - - - - - Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB 8552184 1997-03-12
Gi/o αt1 Bovine - 93 - - - - X-ray 1TAD - 1.7 - - - - - - - - - - - - - Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB 7969474 1995-05-08
Gi/o αt1 Bovine - 93 - - - - X-ray 1TAG - 1.8 - - - - - - - - - - - - - Lambright DG, Noel JP, Hamm HE, Sigler PB 8208289 1995-02-07
Gi/o αt1 Bovine - 93 - - - - X-ray 1TND - 2.2 - - - - - - - - - - - - - Noel JP, Hamm HE, Sigler PB 8259210 1994-07-31
Gi/o αt2 Human - 100 - - - - X-ray 6N85 - 2.5 - - - - - - - Synembryn-A - - - - - Srivastava D, Gakhar L, Artemyev NO 31300652 2019-07-10
Gi/o αt2 Human - 100 - - - - X-ray 6N84 - 1.8 - - - - - - - - - - - - - Srivastava D, Gakhar L, Artemyev NO 31300652 2019-07-10
Gi/o αt2 Bovine - 3 - - - - X-ray 6PH7 - 2.9 - - - - - - - Rhodopsin - - - - - - - 2020-07-01
Gi/o αt2 Bovine - 3 - - - - X-ray 6PGS - 2.9 - - - - - - - Rhodopsin - - - - - - - 2020-07-01
Gi/o αo Mouse - 94 - - - - X-ray 3C7K - 2.9 - - - - - - - Regulator of G-protein signaling 16 - - - - - Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB 18434540 2008-05-06
Gq/11 αq Human - 100 - - - - cryo-EM 6VU5 - 3.5 - - - - - - - Resistance to inhibitors of cholinesterase-8A (Ric-8A) - - - - - Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G 32126208 2020-03-18
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ5 - 3.4 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Begley JA, Manett TD, Tesmer JJG 25435326 2014-10-22
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ3 - 3.0 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Begley JA, Manett TD, Tesmer JJG 25435326 2014-10-22
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ4 - 3.3 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Begley JA, Manett TD, Tesmer JJG 25435326 2014-10-22
Gq/11 αq Mouse - 91 - - - - X-ray 3OHM - 2.7 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK 20966218 2010-10-27
Gq/11 αq Mouse - 98 - - - - X-ray 4GNK - 4.0 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ 23377541 2013-02-06
Gq/11 αq Mouse - 97 - - - - X-ray 4EKC - 7.4 - - - - - - - Regulator of G-protein signaling 2 - - - - - Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ 23434405 2013-01-30
Gq/11 αq Mouse - 97 - - - - X-ray 4EKD - 2.7 - - - - - - - Regulator of G-protein signaling 2 - - - - - Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ 23434405 2013-01-30
Gq/11 αq Mouse - 87 - - - - X-ray 5DO9 - 2.6 - - - - - - - Regulator of G-protein signaling 8 - - - - - Taylor VG, Bommarito PA, Tesmer JJ 26755720 2016-01-20
G12/13 α12 Mouse - 95 - - - - X-ray 1ZCA - 2.9 - - - - - - - - - - - - - Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T 16388592 2005-11-15
G12/13 α13 Mouse - 90 - - - - X-ray 3CX8 - 2.0 - - - - - - - Rho guanine nucleotide exchange factor 11 - - - - - Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR 18940608 2008-10-28
G12/13 α13 Mouse - 90 - - - - X-ray 3CX6 - 2.5 - - - - - - - Rho guanine nucleotide exchange factor 11 - - - - - Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR 18940608 2008-10-28
G12/13 α13 Mouse - 90 - - - - X-ray 3CX7 - 2.3 - - - - - - - Glutamate Transporter Associated Protein 48 - - - - - Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR 18940608 2008-10-28
G12/13 α13 Mouse - 96 - - - - X-ray 3AB3 - 2.4 - - - - - - - Rho guanine nucleotide exchange factor 1 - - - - - Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T 21507947 2010-12-29
G12/13 α13 Mouse - 96 - - - - X-ray 1ZCB - 2.0 - - - - - - - - - - - - - Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T 16388592 2005-11-15