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G PROTEIN
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STRUCTURE
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RECEPTOR
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OTHER PROTEINS
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STRUCTURE LIGAND
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ENDOGENOUS LIGAND
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REFERENCE
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Fam. | α | Species | Note | % of Seq | β | Species | γ | Species | Method |
PDB
|
Refined structure |
Resolution |
UniProt
|
IUPHAR | Receptor family | Class | Species | Receptor fusion | Antibodies | Other | Name | Type | Function | Name | Type | Authors | Reference | PDB Date | ||
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7D7M | 7D7M_refined | 3.3 | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Dinoprostone
pubchem
chembl_ligand
|
small molecule | Agonist | PGE1, PGD2, PGE2, PGF2α, PGI2 | small molecule | - | - | 2020-11-18 | 107 | |
Gi/o | αo | Human | - | 59 | β1 | Rat | γ2 | Mouse | cryo-EM | 6WWZ | 6WWZ_refined | 3.3 | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
CCL20
|
protein | Agonist | CCL20, beta-defensin 4A | protein | Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H | 10.1038/S41467-020-16820-6 | 2020-06-24 | 228 | |
Gi/o | αo | Human | - | 60 | β1 | Mouse | γ2 | Human | cryo-EM | 6K41 | - | 2.9 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | scFv | - |
Dexmedetomidine
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small molecule | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang H, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | 225 | |
Gi/o | αo | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6G79 | - | 3.8 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | - | - |
Donitriptan
pubchem
|
small molecule | Agonist | 5-hydroxytryptamine, tryptamine, 5-HT-moduline | small molecule | García-Nafría J, Nehmé R, Edwards PC, Tate CG | 10.1038/S41586-018-0241-9 | 2018-06-20 | 219 | |
Gs | αs | Bovine | - | 56 | β1 | Rat | γ2 | Bovine | cryo-EM | 6NBI | 6NBI_refined | 4.0 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTHrP, TIP39, PTH, PTHrP-(1-36) | protein | Zhao L, Ma S, Sutkeviciute I, Shen D, Zhou XE, de Waal PW, Li C, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang M, Vilardaga J, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | 134 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 6PB1 | 6PB1_refined | 2.8 | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | - | Nanobody-35 | - |
Urocortin
pubchem
chembl_ligand
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1, urocortin 3 | peptide | Ma S, Shen Q, Zhao L, Mao C, Zhou XE, Shen D, de Waal PW, Bi P, Li C, Jiang Y, Wang M, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | 32 | |
Gi/o | αi1 | Human | Non-canonical conformation | 62 | β1 | Human | γ2 | Human | cryo-EM | 6OSA | 6OSA_refined | 3.0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | - | - | - |
JMV449
pubchem
|
peptide | Agonist | neurotensin, large neurotensin, neuromedin N, large neuromedin N | peptide | Kato HE, Zhang Y, Hu H, Suomivuori C, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41586-019-1337-6 | 2019-07-10 | 158 | |
Gs | αs | Human | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7CZ5 | 7CZ5_refined | 2.6 | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Somatoliberin
pubchem
|
peptide | Agonist | GHRH | peptide | Zhou F, Zhang H, Cong Z, Zhao L, Zhou Q, Mao C, Cheng X, Shen D, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang M | 10.1038/S41467-020-18945-0 | 2020-11-18 | 110 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 6VMS | 6VMS_refined | 3.8 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | T4-Lysozyme | scFv16 | - |
Bromocriptine
pubchem
|
small molecule | Agonist | dopamine | small molecule | Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai X, Sunahara RK, Barth P, Rosenbaum DM | 10.1038/S41586-020-2379-5 | 2020-06-17 | 182 | |
Gq/11 | α11 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 6OIJ | 6OIJ_refined | 3.3 | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | - | Antibody fragment | - |
Iperoxo
pubchem
|
small molecule | Agonist | acetylcholine | small molecule | Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | 237 | |
Gs | αs | Human | Mini-Gs | 61 | β1 | Human | γ2 | Human | cryo-EM | 6LI3 | 6LI3_refined | 3.3 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han G, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | 35 | |
Gi/o | αi1 | Human | - | 100 | β1 | Human | γ2 | Human | cryo-EM | 6PT0 | 6PT0_refined | 3.2 | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
Win 55212-2
pubchem
chembl_ligand
|
small molecule | Agonist | 2-arachidonoylglycerol, anandamide | small molecule | Xing C, Zhuang Y, Xu T, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie X | 10.1016/J.CELL.2020.01.007 | 2020-02-12 | 170 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7CFN | 7CFN_refined | 3.0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
INT-777
pubchem
INT-777 pubchem |
small molecule small molecule |
Agonist PAM |
chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid | small molecule | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen D, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun J, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | 89 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6WPW | 6WPW_refined | 3.1 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Glucagon derivative ZP3780
|
peptide | Agonist | glucagon | peptide | Hilger D, Kumar KK, Hu H, Pedersen MF, O’Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | 59 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 6N4B | 6N4B_refined | 3.0 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
Fub-mdmb
pubchem
|
small molecule | Agonist | 2-arachidonoylglycerol, anandamide | small molecule | Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | 149 | |
Gs | αs | Human | Engineered G protein | 50 | - | - | - | - | X-ray | 5G53 | 5G53_refined | 3.4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | - | - | - |
NECA
pubchem
|
small molecule | Agonist | adenosine | small molecule | Carpenter B, Nehmé R, Warne T, Leslie AGW, Tate CG | 10.1038/NATURE18966 | 2016-08-03 | 1 | |
Gs | αs | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6WZG | 6WZG_refined | 2.3 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
secretin
|
peptide | Agonist | secretin, VIP | peptide | Dong M, Deganutti G, Piper SJ, Liang Y, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | 65 | |
Gq/11 | αq | Human | Gq-Gi2 chimera | 59 | β1 | Human | γ2 | Human | cryo-EM | 6WHA | 6WHA_refined | 3.4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | BRIL | scFv16 | Gq |
25-CN-NBOH
pubchem
|
small molecule | Agonist | 5-hydroxytryptamine, tryptamine | small molecule | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | 240 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6P9Y | 6P9Y_refined | 3.0 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
PACAP
pubchem
|
peptide | Agonist | VIP, PACAP-27, PACAP-38, PHM, PHV, PHI | peptide | Liang Y, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | 26 | |
Gs | αs | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6VN7 | 6VN7_refined | 3.2 | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
PACAP
pubchem
|
peptide | Agonist | secretin, GHRH, VIP, PACAP-27, PACAP-38, PHM, PHV, PHI | peptide | Duan J, Shen D, Zhou XE, Bi P, Liu Q, Tan Y, Zhuang Y, Zhang H, Xu P, Huang S, Ma S, He X, Melcher K, Zhang Y, Xu HE, Jiang Y | 10.1038/S41467-020-17933-8 | 2020-09-02 | 101 | |
Gs | αs | Human | - | 89 | β1 | Human | γ2 | Human | cryo-EM | 6X19 | 6X19_refined | 2.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
CHU-128
pubchem
|
small molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang Y, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1101/2020.08.16.252585 | 2020-09-09 | 98 | |
Gi/o | αi1 | Human | - | 65 | β1 | Human | γ2 | Human | cryo-EM | 6LFO | 6LFO_refined | 3.4 | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
Interleukin-8
pubchem
|
protein | Agonist | CXCL6, CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 | protein | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu Z | 10.1038/S41586-020-2492-5 | 2020-09-02 | 185 | |
Gi/o | αi2 | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6D9H | 6D9H_refined | 3.6 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | - | - | - |
adenosine
pubchem
|
small molecule | Agonist | adenosine | small molecule | Draper-Joyce CJ, Khoshouei M, Thal DM, Liang Y, Nguyen ATN, Furness SGB, Venugopal H, Baltos J, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A | 10.1038/S41586-018-0236-6 | 2018-06-20 | 215 | |
Gs | αs | Human | - | 43 | β1 | Human | γ2 | Human | cryo-EM | 6NIY | 6NIY_refined | 3.3 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | - | - |
calcitonin
|
peptide | Agonist | calcitonin, adrenomedullin, amylin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin | peptide | dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramírez-Aportela E, Carazo J, Hick CA, Furness SGB, Hay DL, Liang Y, Miller LJ, Christopoulos A, Wang M, Wootten D, Sexton PM | 10.1021/ACSPTSCI.8B00056 | 2019-01-23 | 5 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6UUS | 6UUS_refined | 2.4 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP3 |
- |
adrenomedullin
|
peptide | Agonist | adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) | peptide | Liang Y, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | 41 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBM | 6XBM_refined | 3.2 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
24,25-Epoxy-cholesterol
pubchem
24,25-Epoxy-cholesterol pubchem |
small molecule small molecule |
Agonist PAM |
constitutive | constitutive | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 197 | |
Gs | αs | Bovine | - | 89 | β1 | Rat | γ2 | Bovine | X-ray | 3SN6 | 3SN6_refined | 3.2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | Antibody | - |
BI-167107
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ | small molecule | Rasmussen SGF, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah STA, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK | 10.1038/NATURE10361 | 2011-07-20 | 125 | |
Gs | αs | Human | - | 56 | β1 | Rat | γ2 | Bovine | cryo-EM | 7BW0 | 7BW0_refined | 3.9 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | BRIL | Nanobody-35 | - | - | - | - | chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid | small molecule | Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R | 10.1038/S41392-020-00262-Z | 2020-09-02 | 80 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6B3J | 6B3J_refined | 3.3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | - | - |
Exendin-P5
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Liang Y, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang M, Miller LJ, Christopoulos A, Sexton PM, Wootten D | 10.1038/NATURE25773 | 2018-02-21 | 11 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6E3Y | 6E3Y_refined | 3.3 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP1 |
- |
Calcitonin gene-related peptide 1
pubchem
|
peptide | Agonist | adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) | peptide | Liang Y, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM | 10.1038/S41586-018-0535-Y | 2018-09-19 | 20 | |
Gs | αs | Human | - | 57 | β1 | Human | γ2 | Human | cryo-EM | 6GDG | 6GDG_refined | 4.1 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | TrxA | Nanobody | - |
NECA
pubchem
|
small molecule | Agonist | adenosine | small molecule | García-Nafría J, Lee Y, Bai X, Carpenter B, Tate CG | 10.7554/ELIFE.35946 | 2018-05-16 | 14 | |
Gs | αs | Human | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7D3S | 7D3S_refined | 2.9 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
secretin
|
peptide | Agonist | secretin, VIP | peptide | Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O | 10.1016/J.BBRC.2020.08.042 | 2020-11-04 | 104 | |
Gs | αs | Bovine | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 6NBF | 6NBF_refined | 3.0 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTHrP, TIP39, PTH, PTHrP-(1-36) | protein | Zhao L, Ma S, Sutkeviciute I, Shen D, Zhou XE, de Waal PW, Li C, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang M, Vilardaga J, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | 128 | |
Gs | αs | Human | - | 57 | β1 | Rat | γ2 | Bovine | cryo-EM | 6LPB | 6LPB_refined | 3.9 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
PACAP
pubchem
|
peptide | Agonist | VIP, PACAP-27, PACAP-38, PHM, PHV, PHI | peptide | Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O | 10.1038/S41594-020-0386-8 | 2020-03-11 | 50 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 6KPG | 6KPG_refined | 3.0 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
(6Ar,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
pubchem
|
small molecule | Agonist | 2-arachidonoylglycerol, anandamide | small molecule | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu Z | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | 164 | |
Gs | αs | Human | Gs-Gi1 chimera | 58 | β1 | Human | γ2 | Human | cryo-EM | 6PB0 | 6PB0_refined | 3.0 | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | - | Nanobody-35 | - |
Urocortin
pubchem
chembl_ligand
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1 | peptide | Ma S, Shen Q, Zhao L, Mao C, Zhou XE, Shen D, de Waal PW, Bi P, Li C, Jiang Y, Wang M, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | 29 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBK | 6XBK_refined | 3.2 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
Cholesterol
pubchem
|
N/A | Agonist | constitutive | constitutive | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 191 | |
Gi/o | αo | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6OIK | 6OIK_refined | 3.6 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | - | - | - |
Iperoxo
pubchem
2CU pubchem |
small molecule small molecule |
Agonist PAM |
acetylcholine | small molecule | Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | 222 | |
GPa1 | αPa1 | strain ATCC 204508 / S288c | Two alpha subunits bound to STE2 dimer | 29 | STE4 | strain ATCC 204508 / S288c | γ | strain ATCC 204508 / S288c | cryo-EM | 7AD3 | - | 3.5 | STE2 | STE2 | STE2 | D1 (Ste2-like fungal pheromone) | strain ATCC 204508 / S288c | - | - | Gpa1 |
Alpha-factor mating pheromone
pubchem
|
peptide | Agonist | - | - | Velazhahan V, Ma N, Pándy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG | 10.1038/S41586-020-2994-1 | 2020-12-09 | 243 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6OMM | 6OMM_refined | 3.2 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | - | - | - |
WKYMVX
|
peptide | Agonist | annexin I, humanin, LL-37, serum amyloid A, PrP106-126, CRAMP, LXA4, aspirin triggered lipoxin A4, resolvin D1, aspirin-triggered resolvin D1 | protein | Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu T, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C | 10.1038/S41467-020-14728-9 | 2020-02-26 | 173 | |
Gi/o | αi1 | Human | - | 62 | β1 | Mouse | γ2 | Human | cryo-EM | 6K42 | - | 4.1 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | scFv | - |
Dexmedetomidine
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small molecule | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang H, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | 179 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBL | 6XBL_refined | 3.9 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
SAG
pubchem
Cholesterol pubchem |
small molecule N/A |
PAM Agonist |
constitutive | constitutive | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 200 | |
Gs | αs | Human | - | 57 | β1 | Human | γ2 | Human | cryo-EM | 6VCB | 6VCB_refined | 3.3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
GLP-1
LSN3160440 pubchem |
peptide small molecule |
Agonist PAM |
glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jiménez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW | 10.1038/S41589-020-0589-7 | 2020-07-22 | 53 | |
Gi/o | αi1 | Human | Non-canonical conformation | 95 | β1 | Human | γT1 | Human | cryo-EM | 7L0S | 7L0S_refined | 4.5 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
chembl_ligand
|
peptide | Agonist | neurotensin, large neurotensin, neuromedin N, large neuromedin N | peptide | - | - | 2021-01-06 | 212 | |
Gi/o | αi1 | Human | - | 65 | β1 | Human | γ2 | Human | cryo-EM | 6LFM | 6LFM_refined | 3.5 | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
Interleukin-8
pubchem
|
protein | Agonist | CXCL6, CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 | protein | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu Z | 10.1038/S41586-020-2492-5 | 2020-09-02 | 188 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6UUN | 6UUN_refined | 3.0 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP2 |
- |
adrenomedullin
|
peptide | Agonist | adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) | peptide | Liang Y, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-03-25 | 38 | |
Gs | αs | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7LCI | 7LCI_refined | 2.9 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | - | - |
PF-06882961
pubchem
|
small molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | - | - | 2021-01-20 | 122 | |
Gs | αs | Human | - | 90 | β1 | Human | γ2 | Human | cryo-EM | 6X18 | 6X18_refined | 2.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
GLP-1
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang Y, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1101/2020.08.16.252585 | 2020-09-09 | 95 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6M1I | 6M1I_refined | 3.5 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
PACAP
pubchem
|
peptide | Agonist | VIP, PACAP-27, PACAP-38, PHM, PHV, PHI | peptide | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang H, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | 71 | |
Gi/o | αt1 | Bovine | - | 59 | β1 | Bovine | γT1 | Bovine | cryo-EM | 6OYA | 6OYA_refined | 3.3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | Camelid antibody VHH fragment | - |
Retinal (11-cis)
pubchem
|
small molecule | Agonist | Retinal | small molecule | Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | 234 | |
Gs | αs | Bovine | - | 51 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7JJO | 7JJO_refined | 2.6 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | - | Nanobody-35 | - |
Isoprenaline
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline | small molecule | Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee M, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang X | 10.1016/J.MOLCEL.2020.08.001 | 2020-09-02 | 137 | |
Gs | αs | Human | - | 89 | β1 | Human | γ2 | Human | cryo-EM | 6X1A | 6X1A_refined | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
PF-06882961
pubchem
|
small molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang Y, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1101/2020.08.16.252585 | 2020-09-09 | 92 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7CFM | 7CFM_refined | 3.0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
P395
pubchem
chembl_ligand
|
none | Agonist | chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid | small molecule | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen D, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun J, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | 86 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6UVA | 6UVA_refined | 2.3 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP3 |
- |
Adrenomedullin-2
|
peptide | Agonist | adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) | peptide | Liang Y, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | 44 | |
Gs | αs | Human | - | 47 | β1 | Human | γ2 | Human | cryo-EM | 5UZ7 | 5UZ7_refined | 4.1 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | - | - | - | - | - | calcitonin, adrenomedullin, amylin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin | peptide | Liang Y, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM | 10.1038/NATURE22327 | 2017-05-03 | 2 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6WHC | 6WHC_refined | 3.4 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Dual-agonist peptide P15
|
peptide | Agonist | glucagon | peptide | Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang Y, Ma L, Han S, Yang D, Danev R, Wang M, Wootten D, Wu B, Sexton PM | 10.1074/JBC.RA120.013793 | 2020-05-27 | 56 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 6KPF | 6KPF_refined | 2.9 | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
(6Ar,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
pubchem
|
small molecule | Agonist | 2-arachidonoylglycerol, anandamide | small molecule | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu Z | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | 167 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 6OS9 | 6OS9_refined | 3.0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | - | scFv16 | - |
JMV449
pubchem
|
peptide | Agonist | neurotensin, large neurotensin, neuromedin N, large neuromedin N | peptide | Kato HE, Zhang Y, Hu H, Suomivuori C, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41586-019-1337-6 | 2019-07-10 | 155 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6WI9 | 6WI9_refined | 4.3 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
secretin
|
peptide | Agonist | secretin, VIP | peptide | Dong M, Deganutti G, Piper SJ, Liang Y, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | 62 | |
Gs | αs | Human | - | 54 | β1 | Human | γ2 | Human | cryo-EM | 6XOX | 6XOX_refined | 3.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - |
scFv16 Nanobody-35 |
- |
LY3502970
pubchem
|
small molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW | 10.1073/PNAS.2014879117 | 2020-11-18 | 113 | |
Gs | αs | Human | - | 50 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7BZ2 | 7BZ2_refined | 3.8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Formoterol
pubchem
chembl_ligand
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ | small molecule | Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C | 10.1038/S41421-020-0176-9 | 2020-08-05 | 77 | |
Gi/o | αi1 | Human | - | 100 | β1 | Human | γ2 | Human | cryo-EM | 6OT0 | 6OT0_refined | 3.9 | SMO | SMO | Frizzled | F (Frizzled) | Human | - |
Fab light chain Fab heavy chain |
- |
24,25-Epoxy-cholesterol
pubchem
|
small molecule | Agonist | constitutive | constitutive | Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X | 10.1038/S41586-019-1286-0 | 2019-06-12 | 152 | |
Gi/o | αi1 | Human | Non-canonical conformation | 63 | β1 | Human | γT1 | Human | cryo-EM | 7L0R | 7L0R_refined | 4.2 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
chembl_ligand
|
peptide | Agonist | neurotensin, large neurotensin, neuromedin N, large neuromedin N | peptide | - | - | 2021-01-06 | 209 | |
Gi/o | αi1 | Human | - | 95 | β1 | Human | γT1 | Human | cryo-EM | 7L0Q | 7L0Q_refined | 4.3 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
chembl_ligand
|
peptide | Agonist | neurotensin, large neurotensin, neuromedin N, large neuromedin N | peptide | - | - | 2021-01-06 | 206 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6DDF | 6DDF_refined | 3.5 | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | - | - | - |
DAMGO
pubchem
chembl_ligand
|
peptide | Agonist | [Leu]enkephalin, [Met]enkephalin, dynorphin A-(1-13), dynorphin A, dynorphin A-(1-8), dynorphin B, endomorphin-1, β-endorphin, endomorphin-2 | peptide | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | 143 | |
Gs | αs | Human | - | 59 | β1 | Rat | γ2 | Bovine | cryo-EM | 5VAI | 5VAI_refined | 4.1 | G1SGD4 | GLP-1 | Glucagon | B1 (Secretin) | Rabbit | - | - | - |
GLP-1
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G | 10.1038/NATURE22394 | 2017-05-24 | 8 | |
Gi/o | αi1 | Human | - | 100 | β1 | Rat | γ2 | Bovine | cryo-EM | 6CMO | 6CMO_refined | 4.5 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | BRIL | Fab | - |
Apo (no ligand)
|
none | Apo (no ligand) | Retinal | small molecule | Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE | 10.1038/S41586-018-0215-Y | 2018-06-20 | 146 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6P9X | 6P9X_refined | 2.9 | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | - | Nanobody-35 | - |
Corticoliberin
pubchem
|
peptide | Agonist | urocortin 2, corticotrophin-releasing hormone, urocortin 1 | peptide | Liang Y, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | 23 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBJ | 6XBJ_refined | 3.9 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
Cholesterol
pubchem
|
N/A | Agonist | constitutive | constitutive | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 194 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6LMK | 6LMK_refined | 3.7 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
glucagon
pubchem
|
peptide | Agonist | glucagon | peptide | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang M, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | 47 | |
Gi/o | αo | Human | Mini-Go | 51 | - | - | - | - | X-ray | 6FUF | 6FUF_refined | 3.1 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (11-cis)
pubchem
|
small molecule | Agonist | Retinal | small molecule | Tsai C, Pamula F, Nehmé R, Mühle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX | 10.1126/SCIADV.AAT7052 | 2018-10-03 | 218 | |
Gs | αs | Bovine | - | 57 | β1 | Rat | γ2 | Bovine | cryo-EM | 6NBH | 6NBH_refined | 3.5 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTHrP, TIP39, PTH, PTHrP-(1-36) | protein | Zhao L, Ma S, Sutkeviciute I, Shen D, Zhou XE, de Waal PW, Li C, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang M, Vilardaga J, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | 131 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6DDE | 6DDE_refined | 3.5 | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | - | Antibody | - |
DAMGO
pubchem
chembl_ligand
|
peptide | Agonist | [Leu]enkephalin, [Met]enkephalin, dynorphin A-(1-13), dynorphin A, dynorphin A-(1-8), dynorphin B, endomorphin-1, β-endorphin, endomorphin-2 | peptide | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | 140 | |
Gs | αs | Human | - | 49 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7DHR | 7DHR_refined | 3.8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Isoprenaline
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ | small molecule | Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C | 10.1093/NSR/NWAA284 | 2020-12-16 | 116 | |
Gs | αs | Human | - | 54 | β1 | Human | γ2 | Human | cryo-EM | 6M1H | 6M1H_refined | 3.6 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
Maxadilan
pubchem
|
peptide | Agonist | VIP, PACAP-27, PACAP-38, PHM, PHV, PHI | peptide | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang H, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | 68 | |
Gi/o | αi1 | Human | - | 60 | β1 | Bovine | γT1 | Bovine | cryo-EM | 6QNO | 6QNO_refined | 4.4 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - |
Fab antibody fragment light chain Fab antibody fragment heavy chain |
- |
Retinal (11-cis)
pubchem
|
small molecule | Agonist | Retinal | small molecule | Tsai C, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G | 10.7554/ELIFE.46041 | 2019-07-10 | 161 | |
Gs | αs | Human | - | 55 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7DHI | 7DHI_refined | 3.3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Salbutamol
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ | small molecule | Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C | 10.1093/NSR/NWAA284 | 2020-12-16 | 119 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γT1 | Human | cryo-EM | 7L0P | 7L0P_refined | 4.1 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
chembl_ligand
|
peptide | Agonist | neurotensin, large neurotensin, neuromedin N, large neuromedin N | peptide | - | - | 2021-01-06 | 203 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 7C2E | 7C2E_refined | 4.2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid
pubchem
|
small molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE | 10.1038/S41422-020-0384-8 | 2020-08-26 | 83 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6ORV | - | 3.0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
TT-OAD2
pubchem
|
small molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhao P, Liang Y, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang M, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/s41586-019-1902-z | 2020-01-08 | 74 | |
Gi/o | αt1 | Bovine | - | 64 | β1 | Bovine | γT1 | Bovine | cryo-EM | 6OY9 | 6OY9_refined | 3.9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (11-cis)
pubchem
|
small molecule | Agonist | Retinal | small molecule | Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | 231 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 6LML | 6LML_refined | 3.9 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | scFv16 | - |
glucagon
pubchem
|
peptide | Agonist | glucagon | peptide | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang M, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | 176 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6NI3 | 6NI3_refined | 3.8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
BI-167107
pubchem
|
small molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, Zn2+ | small molecule | Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang L, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ | 10.1038/S41594-019-0330-Y | 2019-11-20 | 17 | |
Gs | αs | Human | - | 100 | - | - | - | - | X-ray | 6E67 | - | 3.7 | - | - | - | - | - | - | - | - | - | - | - | - | - | Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK | 31080070 | 2019-06-05 | 55433 | |
Gs | αs | Human | - | 97 | β1 | Human | γ2 | Human | X-ray | 6EG8 | - | 2.8 | - | - | - | - | - | - | - | - | - | - | - | - | - | Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK | 31080070 | 2019-06-05 | 55433 | |
Gs | αs | Human | - | 96 | - | - | - | - | X-ray | 6AU6 | - | 1.7 | - | - | - | - | - | - | - | - | - | - | - | - | - | Hu Q, Shokat KM | 29628140 | 2018-05-09 | 55433 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 3G82 | - | 3.1 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | - | - | 2010-02-16 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 3C14 | - | 2.7 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | Mou TC, Masada N, Cooper DM, Sprang SR | 19243146 | 2009-02-03 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 3C15 | - | 2.8 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | Mou TC, Masada N, Cooper DM, Sprang SR | 19243146 | 2009-02-03 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 3C16 | - | 2.9 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | Mou TC, Masada N, Cooper DM, Sprang SR | 19243146 | 2009-02-03 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 3MAA | - | 3.0 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | Mou TC, Masada N, Cooper DM, Sprang SR | 19243146 | 2010-04-07 | 55450 | |
Gs | αs | Bovine | - | 96 | - | - | - | - | X-ray | 1CUL | - | 2.4 | - | - | - | - | - | - | - |
TYPE V ADENYLYL CYCLASE TYPE II ADENYLYL CYCLASE |
- | - | - | - | - | Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR | 11087399 | 2001-01-10 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | cryo-EM | 6R3Q | - | 3.4 | - | - | - | - | - | - | - | Adenylate cyclase 9 | - | - | - | - | - | Qi C, Sorrentino S, Medalia O, Korkhov VM | 31023924 | 2019-05-08 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | cryo-EM | 6R4P | - | 3.1 | - | - | - | - | - | - | - | Adenylate cyclase 9 | - | - | - | - | - | Qi C, Sorrentino S, Medalia O, Korkhov VM | 31023924 | 2019-05-08 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | cryo-EM | 6R4O | - | 4.2 | - | - | - | - | - | - | - | Adenylate cyclase 9 | - | - | - | - | - | Qi C, Sorrentino S, Medalia O, Korkhov VM | 31023924 | 2019-05-08 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1AZT | - | 2.3 | - | - | - | - | - | - | - | - | - | - | - | - | - | Sunahara RK, Tesmer JJ, Gilman AG, Sprang SR | 9395396 | 1998-02-25 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1AZS | - | 2.3 | - | - | - | - | - | - | - |
VC1 IIC2 |
- | - | - | - | - | Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR | 9417641 | 1998-02-25 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 2GVZ | - | 3.3 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR | 16766715 | 2006-07-04 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 2GVD | - | 2.9 | - | - | - | - | - | - | - |
Adenylate cyclase type 5 Adenylate cyclase type 2 |
- | - | - | - | - | Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR | 16766715 | 2006-07-04 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1TL7 | - | 2.8 | - | - | - | - | - | - | - |
Adenylate cyclase type V Adenylate cyclase type II |
- | - | - | - | - | Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR | 15591060 | 2004-12-14 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1U0H | - | 2.9 | - | - | - | - | - | - | - |
Adenylate cyclase type V Adenylate cyclase type II |
- | - | - | - | - | Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR | 15591060 | 2004-12-14 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1CJK | - | 3.0 | - | - | - | - | - | - | - |
Adenylate cyclase type V ADENYLATE CYCLASE TYPE II |
- | - | - | - | - | Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR | 10427002 | 1999-08-31 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1CJV | - | 3.0 | - | - | - | - | - | - | - |
Adenylate cyclase type V ADENYLATE CYCLASE TYPE II |
- | - | - | - | - | Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR | 10427002 | 1999-08-31 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1CJU | - | 2.8 | - | - | - | - | - | - | - |
Adenylate cyclase type V ADENYLATE CYCLASE TYPE II |
- | - | - | - | - | Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR | 10427002 | 1999-08-31 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1CJT | - | 2.8 | - | - | - | - | - | - | - |
Adenylate cyclase type V ADENYLATE CYCLASE TYPE II |
- | - | - | - | - | Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR | 10427002 | 1999-08-31 | 55450 | |
Gs | αs | Bovine | - | 100 | - | - | - | - | X-ray | 1CS4 | - | 2.5 | - | - | - | - | - | - | - |
TYPE V ADENYLATE CYCLASE TYPE II ADENYLATE CYCLASE |
- | - | - | - | - | Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR | 11087399 | 2001-01-10 | 55450 | |
Gi/o | αi1 | Human | - | 93 | - | - | - | - | X-ray | 4G5Q | - | 2.9 | - | - | - | - | - | - | - | G-protein-signaling modulator 2 | - | - | - | - | - | - | - | 2012-09-05 | 55435 | |
Gi/o | αi1 | Human | - | 93 | - | - | - | - | X-ray | 3ONW | - | 2.4 | - | - | - | - | - | - | - | Regulator of G-protein signaling 14 | - | - | - | - | - | Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP | 21115486 | 2010-11-24 | 55435 | |
Gi/o | αi1 | Human | - | 92 | - | - | - | - | X-ray | 2XNS | - | 3.4 | - | - | - | - | - | - | - | Regulator of G-protein signaling 14 | - | - | - | - | - | Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B | 21388199 | 2011-06-08 | 55435 | |
Gi/o | αi1 | Human | - | 93 | - | - | - | - | X-ray | 3QI2 | - | 2.8 | - | - | - | - | - | - | - | Regulator of G-protein signaling 14 | - | - | - | - | - | Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP | 22383884 | 2012-02-01 | 55435 | |
Gi/o | αi1 | Human | - | 100 | - | - | - | - | X-ray | 3UMS | - | 2.3 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 2012-02-08 | 55435 | |
Gi/o | αi1 | Human | - | 100 | - | - | - | - | X-ray | 3UMR | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 2012-10-24 | 55435 | |
Gi/o | αi1 | Human | - | 92 | - | - | - | - | X-ray | 3QE0 | - | 3.0 | - | - | - | - | - | - | - | KB752 peptide | - | - | - | - | - | Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP | 22383884 | 2012-01-25 | 55435 | |
Gi/o | αi1 | Human | - | 100 | β1 | Human | γ2 | Human | X-ray | 6CRK | - | 2.0 | - | - | - | - | - | - | single-chain Fv | - | - | - | - | - | - | Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK | 30213947 | 2018-10-24 | 55435 | |
Gi/o | αi1 | Human | - | 100 | β1 | Rat | γ2 | Bovine | X-ray | 5TDH | - | 3.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Liu P, Jia MZ, Zhou XE, De Waal PW, Dickson BM, Liu B, Hou L, Yin YT, Kang YY, Shi Y, Melcher K, Xu HE, Jiang Y | 27498775 | 2016-11-09 | 55435 | |
Gi/o | αi1 | Human | - | 92 | - | - | - | - | X-ray | 2OM2 | - | 2.2 | - | - | - | - | - | - | - | Regulator of G-protein signalling 14 GoLoco motif peptide | - | - | - | - | - | Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B | 17603074 | 2007-07-10 | 55435 | |
Gi/o | αi1 | Human | - | 92 | - | - | - | - | X-ray | 1KJY | - | 2.7 | - | - | - | - | - | - | - | Regulator of G-protein signaling 14 | - | - | - | - | - | Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP | 11976690 | 2002-05-08 | 55435 | |
Gi/o | αi1 | Human | - | 92 | - | - | - | - | X-ray | 2IK8 | - | 2.7 | - | - | - | - | - | - | - | Regulator of G-protein signaling 16 | - | - | - | - | - | Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP | 18434541 | 2006-11-21 | 55435 | |
Gi/o | αi1 | Human | - | 91 | - | - | - | - | X-ray | 2GTP | - | 2.6 | - | - | - | - | - | - | - | Regulator of G-protein signaling 1 | - | - | - | - | - | Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP | 18434541 | 2006-05-23 | 55435 | |
Gi/o | αi1 | Human | - | 100 | - | - | - | - | cryo-EM | 6VU8 | - | 4.1 | - | - | - | - | - | - | - | Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | - | - | - | - | - | Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G | 32126208 | 2020-03-18 | 55435 | |
Gi/o | αi1 | Human | - | 88 | - | - | - | - | X-ray | 2G83 | - | 2.8 | - | - | - | - | - | - | - | KB-1753 phage display peptide | - | - | - | - | - | Johnston CA, Lobanova ES, Shavkunov AS, Low J, Ramer JK, Blaesius R, Fredericks Z, Willard FS, Kuhlman B, Arshavsky VY, Siderovski DP | 16981699 | 2006-10-10 | 55435 | |
Gi/o | αi1 | Human | - | 93 | - | - | - | - | X-ray | 1Y3A | - | 2.5 | - | - | - | - | - | - | - | KB752 peptide | - | - | - | - | - | Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP | 16004878 | 2005-07-12 | 55435 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 3D7M | - | 2.9 | - | - | - | - | - | - | - | - | - | - | - | - | - | Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM | 19222191 | 2009-03-03 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 4N0D | - | 1.6 | - | - | - | - | - | - | - | - | - | - | - | - | - | Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM | 24596087 | 2014-03-12 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 4N0E | - | 2.1 | - | - | - | - | - | - | - | - | - | - | - | - | - | Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM | 24596087 | 2014-03-12 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 4PAM | - | 2.1 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE | 25037222 | 2014-07-30 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 4PAN | - | 2.4 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE | 25037222 | 2014-07-30 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 4PAO | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE | 25037222 | 2014-07-30 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 4PAQ | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE | 25037222 | 2014-07-30 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | β1 | Bovine | γ2 | Bovine | X-ray | 3AH8 | - | 2.9 | - | - | - | - | - | - | - | YM-254890 | - | - | - | - | - | Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H | 20639466 | 2010-07-21 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 2ZJZ | - | 2.6 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 2009-03-24 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 2ZJY | - | 2.8 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 2009-03-24 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 3V00 | - | 2.9 | - | - | - | - | - | - | - | - | - | - | - | - | - | Singh G, Ramachandran S, Cerione RA | 22448927 | 2012-04-18 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 3FFA | - | 2.3 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP | 19703466 | 2009-10-06 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 3FFB | - | 2.6 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP | 19703466 | 2009-10-06 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 6TYL | - | 3.3 | - | - | - | - | - | - |
Nanobody A Nanobody B Nanobody C |
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | - | - | - | - | - | McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR | 32103024 | 2020-03-11 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 2RGN | - | 3.5 | - | - | - | - | - | - | - |
Rho guanine nucleotide exchange factor 25 Transforming protein RhoA |
- | - | - | - | - | Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ | 18096806 | 2008-01-15 | 55495 | |
Gi/o | αi1 | Rat | - | 92 | - | - | - | - | X-ray | 1FQK | - | 2.3 | - | - | - | - | - | - | - | Regulator of G-protein signaling 9 | - | - | - | - | - | Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB | 11234020 | 2001-02-28 | 55495 | |
Gi/o | αi1 | Rat | - | 92 | - | - | - | - | X-ray | 1FQJ | - | 2.0 | - | - | - | - | - | - | - | Regulator of G-protein signaling 9 | - | - | - | - | - | Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB | 11234020 | 2001-02-28 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1GDD | - | 2.2 | - | - | - | - | - | - | - | - | - | - | - | - | - | Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR | 7481799 | 1995-11-27 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1GFI | - | 2.2 | - | - | - | - | - | - | - | - | - | - | - | - | - | Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR | 8073283 | 1995-03-31 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | β1 | Bovine | γ2 | Bovine | X-ray | 1GG2 | - | 2.4 | - | - | - | - | - | - | - | - | - | - | - | - | - | Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR | 8521505 | 1997-02-12 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1GIL | - | 2.3 | - | - | - | - | - | - | - | - | - | - | - | - | - | Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR | 8073283 | 1995-02-14 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1GIA | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR | 8073283 | 1994-09-30 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1GIT | - | 2.6 | - | - | - | - | - | - | - | - | - | - | - | - | - | Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR | 8939752 | 1997-02-12 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 6M8H | - | 2.1 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 2019-08-21 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 5KDL | - | 2.7 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE | 27462082 | 2016-08-03 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | β1 | Bovine | γT1 | Bovine | X-ray | 5KDO | - | 1.9 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE | 27462082 | 2016-08-03 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | β1 | Bovine | γ2 | Bovine | X-ray | 1GP2 | - | 2.3 | - | - | - | - | - | - | - | - | - | - | - | - | - | Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR | 8521505 | 1997-02-12 | 55495 | |
Gi/o | αi1 | Rat | - | 91 | - | - | - | - | cryo-EM | 6UKT | - | 3.9 | - | - | - | - | - | - |
NB8109 NB8117 NB8119 NB9156 |
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | - | - | - | - | - | McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR | 32103024 | 2020-03-11 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1AGR | - | 2.8 | - | - | - | - | - | - | - | RGS4 | - | - | - | - | - | Tesmer JJ, Berman DM, Gilman AG, Sprang SR | 9108480 | 1997-06-16 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1AS3 | - | 2.4 | - | - | - | - | - | - | - | - | - | - | - | - | - | Raw AS, Coleman DE, Gilman AG, Sprang SR | 9398294 | 1997-11-12 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1AS2 | - | 2.8 | - | - | - | - | - | - | - | - | - | - | - | - | - | Raw AS, Coleman DE, Gilman AG, Sprang SR | 9398294 | 1997-11-12 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1AS0 | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Raw AS, Coleman DE, Gilman AG, Sprang SR | 9398294 | 1997-11-12 | 55495 | |
Gi/o | αi1 | Rat | - | 89 | - | - | - | - | X-ray | 1BH2 | - | 2.1 | - | - | - | - | - | - | - | - | - | - | - | - | - | Posner BA, Mixon MB, Wall MA, Sprang SR, Gilman AG | 9705312 | 1998-11-04 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1BOF | - | 2.2 | - | - | - | - | - | - | - | - | - | - | - | - | - | Coleman DE, Sprang SR | 9772163 | 1999-01-06 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1CIP | - | 1.5 | - | - | - | - | - | - | - | - | - | - | - | - | - | Coleman DE, Sprang SR | 10358003 | 1999-04-09 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | β1 | Bovine | γ2 | Bovine | X-ray | 2BCJ | - | 3.1 | - | - | - | - | - | - | - | G-protein-coupled receptor kinase 2 | - | - | - | - | - | Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ | 16339447 | 2005-12-20 | 55495 | |
Gi/o | αi1 | Rat | - | 96 | - | - | - | - | X-ray | 1SHZ | - | 2.9 | - | - | - | - | - | - | - |
Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera Rho guanine nucleotide exchange factor 1 |
- | - | - | - | - | Chen Z, Singer WD, Sternweis PC, Sprang SR | 15665872 | 2005-01-18 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1SVK | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR | 15128951 | 2004-06-01 | 55495 | |
Gi/o | αi1 | Rat | - | 100 | - | - | - | - | X-ray | 1SVS | - | 1.5 | - | - | - | - | - | - | - | - | - | - | - | - | - | Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR | 15128951 | 2004-06-01 | 55495 | |
Gi/o | αi3 | Human | - | 93 | - | - | - | - | X-ray | 4G5R | - | 3.5 | - | - | - | - | - | - | - | G-protein-signaling modulator 2 | - | - | - | - | - | - | - | 2012-09-05 | 55437 | |
Gi/o | αi3 | Human | - | 93 | - | - | - | - | X-ray | 4G5S | - | 3.6 | - | - | - | - | - | - | - | G-protein-signaling modulator 2 | - | - | - | - | - | - | - | 2012-09-05 | 55437 | |
Gi/o | αi3 | Human | - | 93 | - | - | - | - | X-ray | 4G5O | - | 2.9 | - | - | - | - | - | - | - | G-protein-signaling modulator 2 | - | - | - | - | - | - | - | 2012-09-05 | 55437 | |
Gi/o | αi3 | Human | - | 99 | - | - | - | - | X-ray | 2V4Z | - | 2.8 | - | - | - | - | - | - | - | REGULATOR OF G-PROTEIN SIGNALING 2 | - | - | - | - | - | Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP | 19478087 | 2008-11-04 | 55437 | |
Gi/o | αi3 | Human | - | 99 | - | - | - | - | X-ray | 2ODE | - | 1.9 | - | - | - | - | - | - | - | Regulator of G-protein signaling 8 | - | - | - | - | - | Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP | 18434541 | 2007-02-06 | 55437 | |
Gi/o | αi3 | Human | - | 91 | - | - | - | - | X-ray | 2IHB | - | 2.7 | - | - | - | - | - | - | - | Regulator of G-protein signalling 10 | - | - | - | - | - | Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP | 18434541 | 2006-11-21 | 55437 | |
Gi/o | αi3 | Rat | - | 99 | - | - | - | - | X-ray | 6MHF | - | 2.0 | - | - | - | - | - | - | - | Girdin | - | - | - | - | - | Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I | 31363053 | 2019-07-31 | 55542 | |
Gi/o | αi3 | Rat | - | 99 | - | - | - | - | X-ray | 6MHE | - | 2.2 | - | - | - | - | - | - | - | KB752 peptide | - | - | - | - | - | Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I | 31363053 | 2019-07-31 | 55542 | |
Gi/o | αt1 | Human | - | 3 | - | - | - | - | X-ray | 3RBQ | - | 2.0 | - | - | - | - | - | - | - | Protein unc-119 homolog A | - | - | - | - | - | Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W | 21642972 | 2011-06-08 | 55438 | |
Gi/o | αt1 | Bovine | - | 3 | - | - | - | - | X-ray | 3DQB | - | 3.2 | - | - | - | - | - | - | - | Rhodopsin | - | - | - | - | - | Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP | 18818650 | 2008-09-23 | 55545 | |
Gi/o | αt1 | Bovine | - | 3 | - | - | - | - | X-ray | 4J4Q | - | 2.7 | - | - | - | - | - | - | - | Rhodopsin | - | - | - | - | - | Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP | 24038729 | 2013-10-30 | 55545 | |
Gi/o | αt1 | Bovine | - | 3 | - | - | - | - | X-ray | 2X72 | - | 3.0 | - | - | - | - | - | - | - | RHODOPSIN | - | - | - | - | - | Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF | 21389983 | 2011-03-16 | 55545 | |
Gi/o | αt1 | Bovine | - | 3 | - | - | - | - | X-ray | 3PQR | - | 2.9 | - | - | - | - | - | - | - | Rhodopsin | - | - | - | - | - | Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP | 21389988 | 2011-03-09 | 55545 | |
Gi/o | αt1 | Bovine | - | 3 | - | - | - | - | X-ray | 4A4M | - | 3.3 | - | - | - | - | - | - | - | RHODOPSIN | - | - | - | - | - | Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J | 22198838 | 2012-01-25 | 55545 | |
Gi/o | αt1 | Bovine | - | 3 | - | - | - | - | X-ray | 4BEY | - | 2.9 | - | - | - | - | - | - | - | Rhodopsin | - | - | - | - | - | Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J | 23579341 | 2013-05-08 | 55545 | |
Gi/o | αt1 | Bovine | - | 100 | β1 | Bovine | γT1 | Bovine | X-ray | 1GOT | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB | 8552184 | 1997-03-12 | 55545 | |
Gi/o | αt1 | Bovine | - | 93 | - | - | - | - | X-ray | 1TND | - | 2.2 | - | - | - | - | - | - | - | - | - | - | - | - | - | Noel JP, Hamm HE, Sigler PB | 8259210 | 1994-07-31 | 55545 | |
Gi/o | αt1 | Bovine | - | 100 | - | - | - | - | cryo-EM | 7JSN | - | 3.2 | - | - | - | - | - | - | - |
Rod cGMP-specific 3' 5'-cyclic phosphodiesterase subunit alpha Rod cGMP-specific 3' 5'-cyclic phosphodiesterase subunit beta |
- | - | - | - | - | Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA | 33007200 | 2020-10-21 | 55545 | |
Gi/o | αt1 | Bovine | - | 93 | - | - | - | - | X-ray | 1TAD | - | 1.7 | - | - | - | - | - | - | - | - | - | - | - | - | - | Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB | 7969474 | 1995-05-08 | 55545 | |
Gi/o | αt1 | Bovine | - | 93 | - | - | - | - | X-ray | 1TAG | - | 1.8 | - | - | - | - | - | - | - | - | - | - | - | - | - | Lambright DG, Noel JP, Hamm HE, Sigler PB | 8208289 | 1995-02-07 | 55545 | |
Gi/o | αt2 | Human | - | 100 | - | - | - | - | X-ray | 6N85 | - | 2.5 | - | - | - | - | - | - | - | Synembryn-A | - | - | - | - | - | Srivastava D, Gakhar L, Artemyev NO | 31300652 | 2019-07-10 | 55439 | |
Gi/o | αt2 | Human | - | 100 | - | - | - | - | X-ray | 6N84 | - | 1.8 | - | - | - | - | - | - | - | - | - | - | - | - | - | Srivastava D, Gakhar L, Artemyev NO | 31300652 | 2019-07-10 | 55439 | |
Gi/o | αt2 | Bovine | - | 3 | - | - | - | - | X-ray | 6PH7 | - | 2.9 | - | - | - | - | - | - | - | Rhodopsin | - | - | - | - | - | - | - | 2020-07-01 | 55565 | |
Gi/o | αt2 | Bovine | - | 3 | - | - | - | - | X-ray | 6PGS | - | 2.9 | - | - | - | - | - | - | - | Rhodopsin | - | - | - | - | - | - | - | 2020-07-01 | 55565 | |
Gi/o | αo | Mouse | - | 94 | - | - | - | - | X-ray | 3C7K | - | 2.9 | - | - | - | - | - | - | - | Regulator of G-protein signaling 16 | - | - | - | - | - | Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB | 18434540 | 2008-05-06 | 55620 | |
Gq/11 | αq | Human | - | 100 | - | - | - | - | cryo-EM | 6VU5 | - | 3.5 | - | - | - | - | - | - | - | Resistance to inhibitors of cholinesterase-8A (Ric-8A) | - | - | - | - | - | Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G | 32126208 | 2020-03-18 | 55443 | |
Gq/11 | αq | Mouse | - | 98 | - | - | - | - | X-ray | 4GNK | - | 4.0 | - | - | - | - | - | - | - |
1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3 |
- | - | - | - | - | Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ | 23377541 | 2013-02-06 | 55657 | |
Gq/11 | αq | Mouse | - | 100 | - | - | - | - | X-ray | 4QJ5 | - | 3.4 | - | - | - | - | - | - | - |
1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3 |
- | - | - | - | - | Lyon AM, Begley JA, Manett TD, Tesmer JJG | 25435326 | 2014-10-22 | 55657 | |
Gq/11 | αq | Mouse | - | 100 | - | - | - | - | X-ray | 4QJ3 | - | 3.0 | - | - | - | - | - | - | - |
1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3 |
- | - | - | - | - | Lyon AM, Begley JA, Manett TD, Tesmer JJG | 25435326 | 2014-10-22 | 55657 | |
Gq/11 | αq | Mouse | - | 100 | - | - | - | - | X-ray | 4QJ4 | - | 3.3 | - | - | - | - | - | - | - |
1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3 |
- | - | - | - | - | Lyon AM, Begley JA, Manett TD, Tesmer JJG | 25435326 | 2014-10-22 | 55657 | |
Gq/11 | αq | Mouse | - | 91 | - | - | - | - | X-ray | 3OHM | - | 2.7 | - | - | - | - | - | - | - |
1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3 |
- | - | - | - | - | Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK | 20966218 | 2010-10-27 | 55657 | |
Gq/11 | αq | Mouse | - | 87 | - | - | - | - | X-ray | 5DO9 | - | 2.6 | - | - | - | - | - | - | - | Regulator of G-protein signaling 8 | - | - | - | - | - | Taylor VG, Bommarito PA, Tesmer JJ | 26755720 | 2016-01-20 | 55657 | |
Gq/11 | αq | Mouse | - | 97 | - | - | - | - | X-ray | 4EKC | - | 7.4 | - | - | - | - | - | - | - | Regulator of G-protein signaling 2 | - | - | - | - | - | Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ | 23434405 | 2013-01-30 | 55657 | |
Gq/11 | αq | Mouse | - | 97 | - | - | - | - | X-ray | 4EKD | - | 2.7 | - | - | - | - | - | - | - | Regulator of G-protein signaling 2 | - | - | - | - | - | Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ | 23434405 | 2013-01-30 | 55657 | |
G12/13 | α12 | Mouse | - | 95 | - | - | - | - | X-ray | 1ZCA | - | 2.9 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T | 16388592 | 2005-11-15 | 55721 | |
G12/13 | α13 | Mouse | - | 90 | - | - | - | - | X-ray | 3CX8 | - | 2.0 | - | - | - | - | - | - | - | Rho guanine nucleotide exchange factor 11 | - | - | - | - | - | Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR | 18940608 | 2008-10-28 | 55740 | |
G12/13 | α13 | Mouse | - | 90 | - | - | - | - | X-ray | 3CX6 | - | 2.5 | - | - | - | - | - | - | - | Rho guanine nucleotide exchange factor 11 | - | - | - | - | - | Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR | 18940608 | 2008-10-28 | 55740 | |
G12/13 | α13 | Mouse | - | 90 | - | - | - | - | X-ray | 3CX7 | - | 2.3 | - | - | - | - | - | - | - | Glutamate Transporter Associated Protein 48 | - | - | - | - | - | Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR | 18940608 | 2008-10-28 | 55740 | |
G12/13 | α13 | Mouse | - | 96 | - | - | - | - | X-ray | 3AB3 | - | 2.4 | - | - | - | - | - | - | - | Rho guanine nucleotide exchange factor 1 | - | - | - | - | - | Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T | 21507947 | 2010-12-29 | 55740 | |
G12/13 | α13 | Mouse | - | 96 | - | - | - | - | X-ray | 1ZCB | - | 2.0 | - | - | - | - | - | - | - | - | - | - | - | - | - | Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T | 16388592 | 2005-11-15 | 55740 |
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PDB | UniProt | IUPHAR | Rec. family | Class | Species | State | PDB Date |
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