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G PROTEIN
STRUCTURE
RECEPTOR
OTHER PROTEINS
STRUCTURE LIGAND
ENDOGENOUS LIGAND
REFERENCE
Fam. α Species Note % of Seq β Species γ Species Method
PDB
Refined
structure
Resolution
UniProt
IUPHAR Receptor family Class Species Receptor fusion Antibodies Other Name Type Function Name Type Last author Reference PDB Date
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 6PB1 6PB1_refined 2.8 CRFR2 CRF2 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody 35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, cortico... peptide Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12 29
Gi/o αo Human - 59 β1 Human γ2 Human cryo-EM 6G79 - 3.8 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human - - - Donitriptan pubchem
small molecule Agonist 5-hydroxytryptamine,... small molecule Tate CG 10.1038/S41586-018-0241-9 2018-06-20 180
Gi/o αi1 Human Non-canonical confor... 62 β1 Human γ2 Human cryo-EM 6OSA 6OSA_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - - - JMV449 pubchem
peptide Agonist neurotensin, large n... peptide Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10 131
Gi/o αo Human - 59 β1 Rat γ2 Mouse cryo-EM 6WWZ 6WWZ_refined 3.3 CCR6 CCR6 Chemokine A (Rhodopsin) Human - scFv16 - CCL20
protein Agonist CCL20, beta-defensin... protein Wu H 10.1038/S41467-020-16820-6 2020-06-24 189
Gs αs Bovine - 56 β1 Rat γ2 Bovine cryo-EM 6NBI 6NBI_refined 4.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody 35 - Long-acting parathyr...
peptide Agonist PTHrP, TIP39, PTH, P... protein Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17 107
Gi/o αo Human - 60 β1 Mouse γ2 Human cryo-EM 6K41 6K41_refined 2.9 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15 186
Gq/11 α11 Human - 63 β1 Human γ2 Human cryo-EM 6OIJ 6OIJ_refined 3.3 ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human - Antibody fragment - Iperoxo pubchem
small molecule Agonist acetylcholine small molecule Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08 198
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6VMS 6VMS_refined 3.8 DRD2 D2 Dopamine A (Rhodopsin) Human T4-Lysozyme scFv16 - Bromocriptine pubchem
small molecule Agonist dopamine small molecule Rosenbaum DM 10.1038/S41586-020-2379-5 2020-06-17 155
Gs αs Human Mini-Gs 61 β1 Human γ2 Human cryo-EM 6LI3 - 3.3 GPR52 GPR52 A orphans A (Rhodopsin) Human - Nanobody 35 - Apo (no ligand)
none Apo (no ligand) - - Xu F 10.1038/S41586-020-2019-0 2020-02-26 32
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6PT0 6PT0_refined 3.2 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - Win 55212-2 pubchem chembl_ligand
small molecule Agonist 2-arachidonoylglycer... small molecule Xie X 10.1016/J.CELL.2020.01.007 2020-02-12 143
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WPW 6WPW_refined 3.1 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody 35 - Glucagon derivative ...
peptide Agonist glucagon peptide Kobilka BK 10.1126/SCIENCE.ABA3373 2020-08-12 56
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 7CFN 7CFN_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody 35 - INT-777 pubchem
INT-777 pubchem
small molecule
small molecule
Agonist
PAM
chenodeoxycholic aci... small molecule Zhang Y 10.1038/S41586-020-2569-1 2020-09-09 83
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6N4B 6N4B_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - Fub-mdmb pubchem
small molecule Agonist 2-arachidonoylglycer... small molecule Skiniotis G 10.1016/J.CELL.2018.11.040 2019-01-30 122
Gs αs Human Engineered G protein 50 - - - - X-ray 5G53 5G53_refined 3.4 AA2AR A2A Adenosine A (Rhodopsin) Human - - - NECA pubchem
small molecule Agonist adenosine small molecule Tate CG 10.1038/NATURE18966 2016-08-03 1
Gq/11 αq Human Gq-Gi2 chimera 59 β1 Human γ2 Human cryo-EM 6WHA 6WHA_refined 3.4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human BRIL scFv16 Gq 25-CN-NBOH pubchem
small molecule Agonist 5-hydroxytryptamine,... small molecule Roth BL 10.1016/J.CELL.2020.08.024 2020-09-23 201
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6WZG 6WZG_refined 2.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody 35 - secretin
peptide Agonist secretin, VIP peptide Miller LJ 10.1038/S41467-020-17791-4 2020-08-12 62
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6P9Y 6P9Y_refined 3.0 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody 35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Wootten D 10.1016/J.MOLCEL.2020.01.012 2020-02-05 23
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6VN7 6VN7_refined 3.2 VIPR1 VPAC1 VIP and PACAP B1 (Secretin) Human - Nanobody 35 - PACAP pubchem
peptide Agonist secretin, GHRH, VIP,... peptide Jiang Y 10.1038/S41467-020-17933-8 2020-09-02 95
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X19 6X19_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody 35 - CHU-128 pubchem
small molecule Agonist glucagon, glucagon-l... peptide Wootten D 10.1101/2020.08.16.252585 2020-09-09 92
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFO - 3.4 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1,... protein Liu Z 10.1038/S41586-020-2492-5 2020-09-02 158
Gi/o αi2 Human - 59 β1 Human γ2 Human cryo-EM 6D9H 6D9H_refined 3.6 AA1R A1 Adenosine A (Rhodopsin) Human - - - adenosine pubchem
small molecule Agonist adenosine small molecule Christopoulos A 10.1038/S41586-018-0236-6 2018-06-20 176
Gs αs Human - 43 β1 Human γ2 Human cryo-EM 6NIY 6NIY_refined 3.3 CALCR CT Calcitonin B1 (Secretin) Human - - - calcitonin
peptide Agonist calcitonin, adrenome... peptide Sexton PM 10.1021/ACSPTSCI.8B00056 2019-01-23 5
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUS 6UUS_refined 2.4 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3
- adrenomedullin
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01 38
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBM 6XBM_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - 24,25-Epoxy-choleste... pubchem
24,25-Epoxy-choleste... pubchem
small molecule
small molecule
Agonist
PAM
constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 170
Gs αs Bovine - 89 β1 Rat γ2 Bovine X-ray 3SN6 3SN6_refined 3.2 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human T4-Lysozyme Antibody - BI-167107 pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Kobilka BK 10.1038/NATURE10361 2011-07-20 98
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6E3Y 6E3Y_refined 3.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP1
- Calcitonin gene-rela... pubchem
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1038/S41586-018-0535-Y 2018-09-19 20
Gs αs Human - 56 β1 Rat γ2 Bovine cryo-EM 7BW0 7BW0_refined 3.9 GPBAR GPBA Bile acid A (Rhodopsin) Human BRIL Nanobody-35 - - - - chenodeoxycholic aci... small molecule Ren R 10.1038/S41392-020-00262-Z 2020-09-02 77
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6B3J 6B3J_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - - - Exendin-P5
peptide Agonist glucagon, glucagon-l... peptide Wootten D 10.1038/NATURE25773 2018-02-21 11
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6GDG 6GDG_refined 4.1 AA2AR A2A Adenosine A (Rhodopsin) Human TrxA Nanobody - NECA pubchem
small molecule Agonist adenosine small molecule Tate CG 10.7554/ELIFE.35946 2018-05-16 14
Gs αs Bovine - 58 β1 Rat γ2 Bovine cryo-EM 6NBF 6NBF_refined 3.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody 35 - Long-acting parathyr...
peptide Agonist PTHrP, TIP39, PTH, P... protein Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17 101
Gs αs Human - 57 β1 Rat γ2 Bovine cryo-EM 6LPB 6LPB_refined 3.9 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody 35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Nureki O 10.1038/S41594-020-0386-8 2020-03-11 47
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6KPG 6KPG_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hyd... pubchem
small molecule Agonist 2-arachidonoylglycer... small molecule Liu Z 10.1016/J.CELL.2020.01.008 2020-02-12 137
Gs αs Human Gs-Gi1 chimera 58 β1 Human γ2 Human cryo-EM 6PB0 6PB0_refined 3.0 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody 35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, cortico... peptide Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12 26
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBK 6XBK_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 164
Gi/o αo Human - 61 β1 Human γ2 Human cryo-EM 6OIK 6OIK_refined 3.6 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human - - - Iperoxo pubchem
2CU pubchem
small molecule
small molecule
Agonist
PAM
acetylcholine small molecule Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08 183
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6OMM 6OMM_refined 3.2 FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human - - - WKYMVX
peptide Agonist annexin I, humanin, ... protein Zhang C 10.1038/S41467-020-14728-9 2020-02-26 146
Gi/o αi1 Human - 62 β1 Mouse γ2 Human cryo-EM 6K42 6K42_refined 4.1 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15 152
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBL 6XBL_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - SAG pubchem
Cholesterol pubchem
small moelcule
N/A
PAM
Agonist
constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 173
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6VCB 6VCB_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody 35 - GLP-1
LSN3160440 pubchem
peptide
small molecule
Agonist
PAM
glucagon, glucagon-l... peptide Sloop KW 10.1038/S41589-020-0589-7 2020-07-22 50
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFM 6LFM_refined 3.5 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1,... protein Liu Z 10.1038/S41586-020-2492-5 2020-09-02 161
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUN 6UUN_refined 3.0 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP2
- adrenomedullin
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1021/ACSPTSCI.9B00080 2020-03-25 35
Gs αs Human - 90 β1 Human γ2 Human cryo-EM 6X18 6X18_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody 35 - GLP-1
peptide Agonist glucagon, glucagon-l... peptide Wootten D 10.1101/2020.08.16.252585 2020-09-09 89
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6M1I 6M1I_refined 3.5 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody 35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Ma Y 10.1038/S41422-020-0280-2 2020-03-11 68
Gi/o αt1 Bovine - 59 β1 Bovine γT1 Bovine cryo-EM 6OYA 6OYA_refined 3.3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Camelid antibody VHH fragment - Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24 195
Gs αs Bovine - 0 β1 Bovine γ2 Bovine cryo-EM 7JJO 7JJO_refined 2.6 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey - Nanobody 35 - Isoprenaline pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Huang X 10.1016/J.MOLCEL.2020.08.001 2020-09-02 110
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X1A 6X1A_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody 35 - PF-06882961 pubchem
small molecule Agonist glucagon, glucagon-l... peptide Wootten D 10.1101/2020.08.16.252585 2020-09-09 86
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CFM 7CFM_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody 35 - P395 pubchem chembl_ligand
none Agonist chenodeoxycholic aci... small molecule Zhang Y 10.1038/S41586-020-2569-1 2020-09-09 80
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UVA 6UVA_refined 2.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3
- Adrenomedullin-2
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01 41
Gs αs Human - 47 β1 Human γ2 Human cryo-EM 5UZ7 5UZ7_refined 4.1 CALCR CT Calcitonin B1 (Secretin) Human - - - - - - calcitonin, adrenome... peptide Sexton PM 10.1038/NATURE22327 2017-05-03 2
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WHC 6WHC_refined 3.4 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody 35 - Dual-agonist peptide...
peptide Agonist glucagon peptide Sexton PM 10.1074/JBC.RA120.013793 2020-05-27 53
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6KPF 6KPF_refined 2.9 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hyd... pubchem
small molecule Agonist 2-arachidonoylglycer... small molecule Liu Z 10.1016/J.CELL.2020.01.008 2020-02-12 140
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6OS9 6OS9_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - scFv16 - JMV449 pubchem
peptide Agonist neurotensin, large n... peptide Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10 128
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6WI9 6WI9_refined 4.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody 35 - secretin
peptide Agonist secretin, VIP peptide Miller LJ 10.1038/S41467-020-17791-4 2020-08-12 59
Gs αs Human - 50 β1 Bovine γ2 Bovine cryo-EM 7BZ2 7BZ2_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody 35 - Formoterol pubchem chembl_ligand
small molecule Agonist (-)-adrenaline, (-)-... small molecule Tian C 10.1038/S41421-020-0176-9 2020-08-05 74
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6OT0 6OT0_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - Fab light chain
Fab heavy chain
- 24,25-Epoxy-choleste... pubchem
small molecule Agonist constitutive constitutive Li X 10.1038/S41586-019-1286-0 2019-06-12 125
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDF 6DDF_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - - - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Me... peptide Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13 116
Gs αs Human - 59 β1 Rat γ2 Bovine cryo-EM 5VAI 5VAI_refined 4.1 G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit - - - GLP-1
peptide Agonist glucagon, glucagon-l... peptide Skiniotis G 10.1038/NATURE22394 2017-05-24 8
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBJ 6XBJ_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 167
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine cryo-EM 6CMO 6CMO_refined 4.5 OPSD Rhodopsin Opsins A (Rhodopsin) Human BRIL Fab - Apo (no ligand)
none Apo (no ligand) Retinal small molecule Xu HE 10.1038/S41586-018-0215-Y 2018-06-20 119
Gs αs Bovine - 57 β1 Rat γ2 Bovine cryo-EM 6NBH 6NBH_refined 3.5 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody 35 - Long-acting parathyr...
peptide Agonist PTHrP, TIP39, PTH, P... protein Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17 104
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDE 6DDE_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - Antibody - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Me... peptide Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13 113
Gi/o αo Human mini-Go 51 - - - - X-ray 6FUF 6FUF_refined 3.1 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Schertler GFX 10.1126/SCIADV.AAT7052 2018-10-03 179
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6LMK 6LMK_refined 3.7 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody 35 - glucagon pubchem
peptide Agonist glucagon peptide Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01 44
Gs αs Human - 54 β1 Human γ2 Human cryo-EM 6M1H 6M1H_refined 3.6 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody 35 - Maxadilan pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Ma Y 10.1038/S41422-020-0280-2 2020-03-11 65
Gi/o αi1 Human - 60 β1 Bovine γT1 Bovine cryo-EM 6QNO 6QNO_refined 4.4 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Fab antibody fragment light chain
Fab antibody fragment heavy chain
- Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Schertler G 10.7554/ELIFE.46041 2019-07-10 134
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6ORV - 3.0 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody 35 - TT-OAD2 pubchem
small molecule Agonist glucagon, glucagon-l... peptide Wootten D 10.1038/s41586-019-1902-z 2020-01-08 71
Gi/o αt1 Bovine - 64 β1 Bovine γT1 Bovine cryo-EM 6OY9 6OY9_refined 3.9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24 192
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 6LML 6LML_refined 3.9 GLR glucagon Glucagon B1 (Secretin) Human - scFv16 - glucagon pubchem
peptide Agonist glucagon peptide Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01 149
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6NI3 6NI3_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody 35 - BI-167107 pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Lefkowitz RJ 10.1038/S41594-019-0330-Y 2019-11-20 17
Gs αs Human - 100 β1 Human γ2 Human cryo-EM 6P9X - 2.9 - - - - - - Nanobody-35 Corticotropin-releasing factor receptor 1
Corticoliberin
- - - - - Wootten D 32004469 2020-02-05 37072
Gs αs Human - 97 β1 Human γ2 Human X-ray 6EG8 - 2.8 - - - - - - - - - - - - - Kobilka BK 31080070 2019-06-05 37072
Gs αs Human - 100 - - - - X-ray 6E67 - 3.7 - - - - - - - - - - - - - Kobilka BK 31080070 2019-06-05 37072
Gs αs Human - 96 - - - - X-ray 6AU6 - 1.7 - - - - - - - - - - - - - Shokat KM 29628140 2018-05-09 37072
Gs αs Bovine - 100 - - - - X-ray 2GVD - 2.9 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - Sprang SR 16766715 2006-07-04 37089
Gs αs Bovine - 100 - - - - X-ray 3MAA - 3.0 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - Sprang SR 19243146 2010-04-07 37089
Gs αs Bovine - 100 - - - - X-ray 3G82 - 3.1 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - - - 2010-02-16 37089
Gs αs Bovine - 100 - - - - X-ray 2GVZ - 3.3 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - Sprang SR 16766715 2006-07-04 37089
Gs αs Bovine - 100 - - - - X-ray 1AZT - 2.3 - - - - - - - - - - - - - Sprang SR 9395396 1998-02-25 37089
Gs αs Bovine - 100 - - - - X-ray 1AZS - 2.3 - - - - - - - VC1
IIC2
- - - - - Sprang SR 9417641 1998-02-25 37089
Gs αs Bovine - 100 - - - - X-ray 1CJK - 3.0 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II
- - - - - Sprang SR 10427002 1999-08-31 37089
Gs αs Bovine - 100 - - - - X-ray 1CJV - 3.0 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II
- - - - - Sprang SR 10427002 1999-08-31 37089
Gs αs Bovine - 100 - - - - X-ray 1CJU - 2.8 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II
- - - - - Sprang SR 10427002 1999-08-31 37089
Gs αs Bovine - 100 - - - - X-ray 1CJT - 2.8 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II
- - - - - Sprang SR 10427002 1999-08-31 37089
Gs αs Bovine - 100 - - - - X-ray 1CS4 - 2.5 - - - - - - - TYPE V ADENYLATE CYCLASE
TYPE II ADENYLATE CYCLASE
- - - - - Sprang SR 11087399 2001-01-10 37089
Gs αs Bovine - 96 - - - - X-ray 1CUL - 2.4 - - - - - - - TYPE V ADENYLYL CYCLASE
TYPE II ADENYLYL CYCLASE
- - - - - Sprang SR 11087399 2001-01-10 37089
Gs αs Bovine - 100 - - - - X-ray 3C14 - 2.7 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - Sprang SR 19243146 2009-02-03 37089
Gs αs Bovine - 100 - - - - X-ray 3C15 - 2.8 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - Sprang SR 19243146 2009-02-03 37089
Gs αs Bovine - 100 - - - - X-ray 3C16 - 2.9 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2
- - - - - Sprang SR 19243146 2009-02-03 37089
Gs αs Bovine - 100 - - - - X-ray 1TL7 - 2.8 - - - - - - - Adenylate cyclase
type V
Adenylate cyclase
type II
- - - - - Sprang SR 15591060 2004-12-14 37089
Gs αs Bovine - 100 - - - - X-ray 1U0H - 2.9 - - - - - - - Adenylate cyclase
type V
Adenylate cyclase
type II
- - - - - Sprang SR 15591060 2004-12-14 37089
Gs αs Bovine - 100 - - - - cryo-EM 6R3Q - 3.4 - - - - - - - Adenylate cyclase 9 - - - - - Korkhov VM 31023924 2019-05-08 37089
Gs αs Bovine - 100 - - - - cryo-EM 6R4P - 3.1 - - - - - - - Adenylate cyclase 9 - - - - - Korkhov VM 31023924 2019-05-08 37089
Gs αs Bovine - 100 - - - - cryo-EM 6R4O - 4.2 - - - - - - - Adenylate cyclase 9 - - - - - Korkhov VM 31023924 2019-05-08 37089
Gi/o αi1 Human - 92 - - - - X-ray 2IK8 - 2.7 - - - - - - - Regulator of G-protein signaling 16 - - - - - Siderovski DP 18434541 2006-11-21 37074
Gi/o αi1 Human - 93 - - - - X-ray 4G5Q - 2.9 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05 37074
Gi/o αi1 Human - 92 - - - - X-ray 3QE0 - 3.0 - - - - - - - KB752 peptide - - - - - Siderovski DP 22383884 2012-01-25 37074
Gi/o αi1 Human - 93 - - - - X-ray 3ONW - 2.4 - - - - - - - Regulator of G-protein signaling 14 - - - - - Siderovski DP 21115486 2010-11-24 37074
Gi/o αi1 Human - 93 - - - - X-ray 3QI2 - 2.8 - - - - - - - Regulator of G-protein signaling 14 - - - - - Siderovski DP 22383884 2012-02-01 37074
Gi/o αi1 Human - 92 - - - - X-ray 2XNS - 3.4 - - - - - - - Regulator of G-protein signaling 14 - - - - - Kuhlman B 21388199 2011-06-08 37074
Gi/o αi1 Human - 92 - - - - X-ray 2OM2 - 2.2 - - - - - - - Regulator of G-protein signalling 14 GoLoco motif peptide - - - - - Kuhlman B 17603074 2007-07-10 37074
Gi/o αi1 Human - 88 - - - - X-ray 2G83 - 2.8 - - - - - - - KB-1753 phage display peptide - - - - - Siderovski DP 16981699 2006-10-10 37074
Gi/o αi1 Human - 91 - - - - X-ray 2GTP - 2.6 - - - - - - - Regulator of G-protein signaling 1 - - - - - Siderovski DP 18434541 2006-05-23 37074
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine X-ray 5TDH - 3.0 - - - - - - - - - - - - - Jiang Y 27498775 2016-11-09 37074
Gi/o αi1 Human - 100 - - - - X-ray 3UMS - 2.3 - - - - - - - - - - - - - - - 2012-02-08 37074
Gi/o αi1 Human - 100 - - - - X-ray 3UMR - 2.0 - - - - - - - - - - - - - - - 2012-10-24 37074
Gi/o αi1 Human - 100 β1 Human γ2 Human X-ray 6CRK - 2.0 - - - - - - single-chain Fv - - - - - - Kobilka BK 30213947 2018-10-24 37074
Gi/o αi1 Human - 93 - - - - X-ray 1Y3A - 2.5 - - - - - - - KB752 peptide - - - - - Siderovski DP 16004878 2005-07-12 37074
Gi/o αi1 Human - 100 - - - - cryo-EM 6VU8 - 4.1 - - - - - - - Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - Skiniotis G 32126208 2020-03-18 37074
Gi/o αi1 Human - 92 - - - - X-ray 1KJY - 2.7 - - - - - - - Regulator of G-protein signaling 14 - - - - - Siderovski DP 11976690 2002-05-08 37074
Gi/o αi1 Rat - 100 - - - - X-ray 2RGN - 3.5 - - - - - - - Rho guanine nucleotide exchange factor 25
Transforming protein RhoA
- - - - - Tesmer JJ 18096806 2008-01-15 37134
Gi/o αi1 Rat - 100 - - - - X-ray 6TYL - 3.3 - - - - - - Nanobody A
Nanobody B
Nanobody C
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - Sprang SR 32103024 2020-03-11 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1AGR - 2.8 - - - - - - - RGS4 - - - - - Sprang SR 9108480 1997-06-16 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1AS3 - 2.4 - - - - - - - - - - - - - Sprang SR 9398294 1997-11-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1AS2 - 2.8 - - - - - - - - - - - - - Sprang SR 9398294 1997-11-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1AS0 - 2.0 - - - - - - - - - - - - - Sprang SR 9398294 1997-11-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 4PAM - 2.1 - - - - - - - - - - - - - Hamm HE 25037222 2014-07-30 37134
Gi/o αi1 Rat - 100 - - - - X-ray 4PAN - 2.4 - - - - - - - - - - - - - Hamm HE 25037222 2014-07-30 37134
Gi/o αi1 Rat - 100 - - - - X-ray 4PAO - 2.0 - - - - - - - - - - - - - Hamm HE 25037222 2014-07-30 37134
Gi/o αi1 Rat - 100 - - - - X-ray 4PAQ - 2.0 - - - - - - - - - - - - - Hamm HE 25037222 2014-07-30 37134
Gi/o αi1 Rat - 100 - - - - X-ray 4N0D - 1.6 - - - - - - - - - - - - - Iverson TM 24596087 2014-03-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 4N0E - 2.1 - - - - - - - - - - - - - Iverson TM 24596087 2014-03-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 3D7M - 2.9 - - - - - - - - - - - - - Iverson TM 19222191 2009-03-03 37134
Gi/o αi1 Rat - 100 - - - - X-ray 2ZJZ - 2.6 - - - - - - - - - - - - - - - 2009-03-24 37134
Gi/o αi1 Rat - 100 - - - - X-ray 2ZJY - 2.8 - - - - - - - - - - - - - - - 2009-03-24 37134
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 3AH8 - 2.9 - - - - - - - YM-254890 - - - - - Itoh H 20639466 2010-07-21 37134
Gi/o αi1 Rat - 100 - - - - X-ray 3FFA - 2.3 - - - - - - - - - - - - - Sakmar TP 19703466 2009-10-06 37134
Gi/o αi1 Rat - 100 - - - - X-ray 3FFB - 2.6 - - - - - - - - - - - - - Sakmar TP 19703466 2009-10-06 37134
Gi/o αi1 Rat - 100 - - - - X-ray 5KDL - 2.7 - - - - - - - - - - - - - Hamm HE 27462082 2016-08-03 37134
Gi/o αi1 Rat - 100 β1 Bovine γT1 Bovine X-ray 5KDO - 1.9 - - - - - - - - - - - - - Hamm HE 27462082 2016-08-03 37134
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 2BCJ - 3.1 - - - - - - - G-protein-coupled receptor kinase 2 - - - - - Tesmer JJ 16339447 2005-12-20 37134
Gi/o αi1 Rat - 100 - - - - X-ray 3V00 - 2.9 - - - - - - - - - - - - - Cerione RA 22448927 2012-04-18 37134
Gi/o αi1 Rat - 100 - - - - X-ray 6M8H - 2.1 - - - - - - - - - - - - - - - 2019-08-21 37134
Gi/o αi1 Rat - 89 - - - - X-ray 1BH2 - 2.1 - - - - - - - - - - - - - Gilman AG 9705312 1998-11-04 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1BOF - 2.2 - - - - - - - - - - - - - Sprang SR 9772163 1999-01-06 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1CIP - 1.5 - - - - - - - - - - - - - Sprang SR 10358003 1999-04-09 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1GDD - 2.2 - - - - - - - - - - - - - Sprang SR 7481799 1995-11-27 37134
Gi/o αi1 Rat - 92 - - - - X-ray 1FQK - 2.3 - - - - - - - Regulator of G-protein signaling 9 - - - - - Sigler PB 11234020 2001-02-28 37134
Gi/o αi1 Rat - 92 - - - - X-ray 1FQJ - 2.0 - - - - - - - Regulator of G-protein signaling 9 - - - - - Sigler PB 11234020 2001-02-28 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1GFI - 2.2 - - - - - - - - - - - - - Sprang SR 8073283 1995-03-31 37134
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 1GG2 - 2.4 - - - - - - - - - - - - - Sprang SR 8521505 1997-02-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1GIL - 2.3 - - - - - - - - - - - - - Sprang SR 8073283 1995-02-14 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1GIA - 2.0 - - - - - - - - - - - - - Sprang SR 8073283 1994-09-30 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1GIT - 2.6 - - - - - - - - - - - - - Sprang SR 8939752 1997-02-12 37134
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 1GP2 - 2.3 - - - - - - - - - - - - - Sprang SR 8521505 1997-02-12 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1SVK - 2.0 - - - - - - - - - - - - - Sprang SR 15128951 2004-06-01 37134
Gi/o αi1 Rat - 100 - - - - X-ray 1SVS - 1.5 - - - - - - - - - - - - - Sprang SR 15128951 2004-06-01 37134
Gi/o αi1 Rat - 96 - - - - X-ray 1SHZ - 2.9 - - - - - - - Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera
Rho guanine nucleotide exchange factor 1
- - - - - Sprang SR 15665872 2005-01-18 37134
Gi/o αi1 Rat - 91 - - - - cryo-EM 6UKT - 3.9 - - - - - - NB8109
NB8117
NB8119
NB9156
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - Sprang SR 32103024 2020-03-11 37134
Gi/o αi3 Human - 91 - - - - X-ray 2IHB - 2.7 - - - - - - - Regulator of G-protein signalling 10 - - - - - Siderovski DP 18434541 2006-11-21 37076
Gi/o αi3 Human - 93 - - - - X-ray 4G5R - 3.5 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05 37076
Gi/o αi3 Human - 93 - - - - X-ray 4G5S - 3.6 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05 37076
Gi/o αi3 Human - 93 - - - - X-ray 4G5O - 2.9 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05 37076
Gi/o αi3 Human - 99 - - - - X-ray 2V4Z - 2.8 - - - - - - - REGULATOR OF G-PROTEIN SIGNALING 2 - - - - - Siderovski DP 19478087 2008-11-04 37076
Gi/o αi3 Human - 99 - - - - X-ray 2ODE - 1.9 - - - - - - - Regulator of G-protein signaling 8 - - - - - Siderovski DP 18434541 2007-02-06 37076
Gi/o αi3 Rat - 99 - - - - X-ray 6MHF - 2.0 - - - - - - - Girdin - - - - - Kufareva I 31363053 2019-07-31 37181
Gi/o αi3 Rat - 99 - - - - X-ray 6MHE - 2.2 - - - - - - - KB752 peptide - - - - - Kufareva I 31363053 2019-07-31 37181
Gi/o αt1 Human - 3 - - - - X-ray 3RBQ - 2.0 - - - - - - - Protein unc-119 homolog A - - - - - Baehr W 21642972 2011-06-08 37077
Gi/o αt1 Bovine - 3 - - - - X-ray 4J4Q - 2.7 - - - - - - - Rhodopsin - - - - - Ernst OP 24038729 2013-10-30 37184
Gi/o αt1 Bovine - 3 - - - - X-ray 3DQB - 3.2 - - - - - - - Rhodopsin - - - - - Ernst OP 18818650 2008-09-23 37184
Gi/o αt1 Bovine - 3 - - - - X-ray 2X72 - 3.0 - - - - - - - RHODOPSIN - - - - - Schertler GF 21389983 2011-03-16 37184
Gi/o αt1 Bovine - 3 - - - - X-ray 3PQR - 2.9 - - - - - - - Rhodopsin - - - - - Ernst OP 21389988 2011-03-09 37184
Gi/o αt1 Bovine - 100 - - - - cryo-EM 7JSN - 3.2 - - - - - - - Rod cGMP-specific 3'
5'-cyclic phosphodiesterase subunit alpha
Rod cGMP-specific 3'
5'-cyclic phosphodiesterase subunit beta
- - - - - Cerione RA 33007200 2020-10-21 37184
Gi/o αt1 Bovine - 3 - - - - X-ray 4A4M - 3.3 - - - - - - - RHODOPSIN - - - - - Standfuss J 22198838 2012-01-25 37184
Gi/o αt1 Bovine - 3 - - - - X-ray 4BEY - 2.9 - - - - - - - Rhodopsin - - - - - Standfuss J 23579341 2013-05-08 37184
Gi/o αt1 Bovine - 100 β1 Bovine γT1 Bovine X-ray 1GOT - 2.0 - - - - - - - - - - - - - Sigler PB 8552184 1997-03-12 37184
Gi/o αt1 Bovine - 93 - - - - X-ray 1TAD - 1.7 - - - - - - - - - - - - - Sigler PB 7969474 1995-05-08 37184
Gi/o αt1 Bovine - 93 - - - - X-ray 1TAG - 1.8 - - - - - - - - - - - - - Sigler PB 8208289 1995-02-07 37184
Gi/o αt1 Bovine - 93 - - - - X-ray 1TND - 2.2 - - - - - - - - - - - - - Sigler PB 8259210 1994-07-31 37184
Gi/o αt2 Human - 100 - - - - X-ray 6N85 - 2.5 - - - - - - - Synembryn-A - - - - - Artemyev NO 31300652 2019-07-10 37078
Gi/o αt2 Human - 100 - - - - X-ray 6N84 - 1.8 - - - - - - - - - - - - - Artemyev NO 31300652 2019-07-10 37078
Gi/o αt2 Bovine - 3 - - - - X-ray 6PH7 - 2.9 - - - - - - - Rhodopsin - - - - - - - 2020-07-01 37204
Gi/o αt2 Bovine - 3 - - - - X-ray 6PGS - 2.9 - - - - - - - Rhodopsin - - - - - - - 2020-07-01 37204
Gi/o αo Mouse - 94 - - - - X-ray 3C7K - 2.9 - - - - - - - Regulator of G-protein signaling 16 - - - - - Sigler PB 18434540 2008-05-06 37259
Gq/11 αq Human - 100 - - - - cryo-EM 6VU5 - 3.5 - - - - - - - Resistance to inhibitors of cholinesterase-8A (Ric-8A) - - - - - Skiniotis G 32126208 2020-03-18 37082
Gq/11 αq Mouse - 98 - - - - X-ray 4GNK - 4.0 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3
- - - - - Tesmer JJ 23377541 2013-02-06 37296
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ5 - 3.4 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3
- - - - - Tesmer JJG 25435326 2014-10-22 37296
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ3 - 3.0 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3
- - - - - Tesmer JJG 25435326 2014-10-22 37296
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ4 - 3.3 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3
- - - - - Tesmer JJG 25435326 2014-10-22 37296
Gq/11 αq Mouse - 91 - - - - X-ray 3OHM - 2.7 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3
- - - - - Harden TK 20966218 2010-10-27 37296
Gq/11 αq Mouse - 87 - - - - X-ray 5DO9 - 2.6 - - - - - - - Regulator of G-protein signaling 8 - - - - - Tesmer JJ 26755720 2016-01-20 37296
Gq/11 αq Mouse - 97 - - - - X-ray 4EKC - 7.4 - - - - - - - Regulator of G-protein signaling 2 - - - - - Tesmer JJ 23434405 2013-01-30 37296
Gq/11 αq Mouse - 97 - - - - X-ray 4EKD - 2.7 - - - - - - - Regulator of G-protein signaling 2 - - - - - Tesmer JJ 23434405 2013-01-30 37296
G12/13 α12 Mouse - 95 - - - - X-ray 1ZCA - 2.9 - - - - - - - - - - - - - Kozasa T 16388592 2005-11-15 37360
G12/13 α13 Mouse - 90 - - - - X-ray 3CX8 - 2.0 - - - - - - - Rho guanine nucleotide exchange factor 11 - - - - - Sprang SR 18940608 2008-10-28 37379
G12/13 α13 Mouse - 90 - - - - X-ray 3CX6 - 2.5 - - - - - - - Rho guanine nucleotide exchange factor 11 - - - - - Sprang SR 18940608 2008-10-28 37379
G12/13 α13 Mouse - 90 - - - - X-ray 3CX7 - 2.3 - - - - - - - Glutamate Transporter Associated Protein 48 - - - - - Sprang SR 18940608 2008-10-28 37379
G12/13 α13 Mouse - 96 - - - - X-ray 3AB3 - 2.4 - - - - - - - Rho guanine nucleotide exchange factor 1 - - - - - Kozasa T 21507947 2010-12-29 37379
G12/13 α13 Mouse - 96 - - - - X-ray 1ZCB - 2.0 - - - - - - - - - - - - - Kozasa T 16388592 2005-11-15 37379