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G PROTEIN
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STRUCTURE
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RECEPTOR
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OTHER PROTEINS
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STRUCTURE LIGAND
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ENDOGENOUS LIGAND
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REFERENCE
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Fam. | α | Species | Note | % of Seq | β | Species | γ | Species | Method |
PDB
|
Refined structure |
Resolution |
UniProt
|
IUPHAR | Receptor family | Class | Species | Receptor fusion | Antibodies | Other | Name | Type | Function | Name | Type | Authors | Reference | PDB Date | ||
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 3DQB | 3DQB_refined | 3.2 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP | 10.1038/NATURE07330 | 2008-09-23 | 55968 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 2X72 | 2X72_refined | 3.0 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF | 10.1038/NATURE09795 | 2011-03-16 | 55968 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 4X1H | 4X1H_refined | 2.3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
B-Nonylglucoside
pubchem
|
small-molecule | unknown | - | - | Blankenship E, Vahedi-Faridi A, Lodowski DT | 10.1016/J.STR.2015.09.015 | 2015-11-04 | 55968 | |
Gs | αs | Human | Engineered G protein | 50 | - | - | - | - | X-ray | 5G53 | 5G53_refined | 3.4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | - | - | - |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
small-molecule | Agonist | adenosine | small-molecule | Carpenter B, Nehme R, Warne T, Leslie AG, Tate CG | 10.1038/NATURE18966 | 2016-08-03 | 55856 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6DDE | 6DDE_refined | 3.5 | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | - | Antibody | - |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
peptide | Agonist | - | - | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | 55858 | |
Gi/o | αi2 | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6D9H | 6D9H_refined | 3.6 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | - | - | - |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | adenosine | small-molecule | Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A | 10.1038/S41586-018-0236-6 | 2018-06-20 | 55859 | |
Gi/o | αo | Human | Mini-Go | 51 | - | - | - | - | X-ray | 6FUF | 6FUF_refined | 3.1 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Tsai CJ, Pamula F, Nehme R, Muhle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX | 10.1126/SCIADV.AAT7052 | 2018-10-03 | 55864 | |
Gs | αs | Human | - | 50 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7BZ2 | 7BZ2_refined | 3.8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | noradrenaline, Zn2+, (-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline | small-molecule | Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C | 10.1038/S41421-020-0176-9 | 2020-08-05 | 55856 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6WPW | 6WPW_refined | 3.1 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Glucagon derivative ZP3780
|
peptide | Agonist | glucagon | peptide | Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | 55856 | |
Gs | αs | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6VN7 | 6VN7_refined | 3.2 | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
[Ac-His1]PACAP-27
gtoplig
chembl_ligand
pubchem
|
peptide | Agonist | GHRH, PHI, PACAP-38, PACAP-27, PHM, VIP, secretin | peptide | Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y | 10.1038/S41467-020-17933-8 | 2020-09-02 | 55856 | |
Gs | αs | Human | - | 90 | β1 | Human | γ2 | Human | cryo-EM | 6X18 | 6X18_refined | 2.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
protein | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D | 10.1101/2020.08.16.252585 | 2020-09-09 | 55856 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBJ | 6XBJ_refined | 3.9 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
Cholesterol
pubchem
|
small-molecule | Agonist | - | - | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBM | 6XBM_refined | 3.2 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
24,25-Epoxy-cholesterol
pubchem
24,25-Epoxy-cholesterol pubchem |
small-molecule small-molecule |
Agonist PAM |
- | - | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 55858 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 4BEY | 4BEY_refined | 2.9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J | 10.1038/EMBOR.2013.44 | 2013-05-08 | 55968 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6E3Y | 6E3Y_refined | 3.3 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP1 |
- |
Calcitonin gene-related peptide 1
pubchem
|
peptide | Agonist | - | - | Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM | 10.1038/S41586-018-0535-Y | 2018-09-19 | 55856 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6WI9 | 6WI9_refined | 4.3 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
SECRETIN
chembl_ligand
pubchem
|
protein | Agonist | VIP, secretin | peptide | Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | 55856 | |
Gi/o | αi1 | Human | - | 65 | β1 | Human | γ2 | Human | cryo-EM | 6LFM | 6LFM_refined | 3.5 | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
Interleukin-8
pubchem
|
protein | Agonist | CXCL7, CXCL5, CXCL8, CXCL3, CXCL6, CXCL1, CXCL2 | peptide | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | 55858 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7CFN | 7CFN_refined | 3.0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
INT-777
pubchem
INT-777 pubchem |
small-molecule small-molecule |
Agonist PAM |
deoxycholic acid, cholic acid, chenodeoxycholic acid, lithocholic acid | small-molecule | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | 55856 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 4A4M | 4A4M_refined | 3.3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J | 10.1073/PNAS.1114089108 | 2012-01-25 | 55968 | |
Gs | αs | Human | - | 47 | β1 | Human | γ2 | Human | cryo-EM | 5UZ7 | 5UZ7_refined | 4.1 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | - | - | - | - | - | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM | 10.1038/NATURE22327 | 2017-05-03 | 55856 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6B3J | 6B3J_refined | 3.3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | - | - |
Exendin-P5
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D | 10.1038/NATURE25773 | 2018-02-21 | 55856 | |
Gs | αs | Human | - | 57 | β1 | Human | γ2 | Human | cryo-EM | 6GDG | 6GDG_refined | 4.1 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | TrxA | Nanobody-35 | - |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
small-molecule | Agonist | adenosine | small-molecule | Garcia-Nafria J, Lee Y, Bai X, Carpenter B, Tate CG | 10.7554/ELIFE.35946 | 2018-05-16 | 55856 | |
Gi/o | αo | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6G79 | 6G79_refined | 3.8 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | - | - |
donitriptan
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | tryptamine, 5-HT-moduline, 5-hydroxytryptamine | small-molecule | Garcia-Nafria J, Nehme R, Edwards PC, Tate CG | 10.1038/S41586-018-0241-9 | 2018-06-20 | 55864 | |
Gs | αs | Human | - | 43 | β1 | Human | γ2 | Human | cryo-EM | 6NIY | 6NIY_refined | 3.3 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | - | - |
Calcitonin salmon
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramirez-Aportela E, Carazo JM, Hick CA, Furness SGB, Hay DL, Liang YL, Miller LJ, Christopoulos A, Wang MW, Wootten D, Sexton PM | 10.1021/ACSPTSCI.8B00056 | 2019-01-23 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 6N4B | 6N4B_refined | 3.0 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
MDMB-Fubinaca
pubchem
gtoplig
|
small-molecule | Agonist | anandamide, 2-arachidonoylglycerol | small-molecule | Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | 55858 | |
Gs | αs | Bovine | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 6NBF | 6NBF_refined | 3.0 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTHrP, PTH, TIP39, PTHrP-(1-36) | peptide | Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | 55873 | |
Gs | αs | Bovine | - | 56 | β1 | Rat | γ2 | Bovine | cryo-EM | 6NBI | 6NBI_refined | 4.0 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTHrP, PTH, TIP39, PTHrP-(1-36) | peptide | Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | 55873 | |
Gq/11 | α11 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 6OIJ | 6OIJ_refined | 3.3 | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | - | Antibody fragment | - |
iperoxo
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | acetylcholine | small-molecule | Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | 55867 | |
Gs | αs | Human | Fused partial Gs | 44 | - | - | - | - | X-ray | 6E67 | 6E67_refined | 3.7 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | - | - |
CHEMBL1615159
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, Zn2+, (-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline | small-molecule | Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK | 10.1016/J.CELL.2019.04.021 | 2019-06-05 | 55856 | |
Gi/o | αi1 | Human | Non-canonical conformation | 62 | β1 | Human | γ2 | Human | cryo-EM | 6OSA | 6OSA_refined | 3.0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | - | - | - |
JMV449
pubchem
gtoplig
chembl_ligand
|
peptide | Agonist | neuromedin N, neurotensin, large neurotensin, large neuromedin N | peptide | Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41586-019-1337-6 | 2019-07-10 | 55858 | |
Gi/o | αt1 | Bovine | - | 59 | β1 | Bovine | γT1 | Bovine | cryo-EM | 6OYA | 6OYA_refined | 3.3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | Camelid antibody VHH fragment | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | 55968 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6NI3 | 6NI3_refined | 3.8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL1615159
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, Zn2+, (-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline | small-molecule | Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ | 10.1038/S41594-019-0330-Y | 2019-11-20 | 55856 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 3PQR | - | 2.9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP | 10.1038/NATURE09789 | 2011-03-09 | 55968 | |
Gs | αs | Bovine | - | 89 | β1 | Rat | γ2 | Bovine | X-ray | 3SN6 | 3SN6_refined | 3.2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | Antibody | - |
CHEMBL1615159
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, Zn2+, (-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline | small-molecule | Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK | 10.1038/NATURE10361 | 2011-07-20 | 55873 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 4J4Q | 4J4Q_refined | 2.7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
B-Octylglucoside
pubchem
|
small-molecule | unknown | - | - | Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP | 10.1002/ANIE.201302374 | 2013-10-30 | 55968 | |
Gi/o | αt3 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 5EN0 | 5EN0_refined | 2.8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Singhal A, Guo Y, Matkovic M, Schertler G, Deupi X, Yan EC, Standfuss J | 10.15252/EMBR.201642671 | 2016-08-10 | 56012 | |
Gs | αs | Human | - | 59 | β1 | Rat | γ2 | Bovine | cryo-EM | 5VAI | 5VAI_refined | 4.1 | G1SGD4 | GLP-1 | Glucagon | B1 (Secretin) | Rabbit | - | - | - |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
protein | Agonist | - | - | Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G | 10.1038/NATURE22394 | 2017-05-24 | 55856 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 5WKT | 5WKT_refined | 3.2 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
B-Octylglucoside
pubchem
|
small-molecule | unknown | - | - | Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP | 10.1038/NPROT.2017.135 | 2017-12-13 | 55968 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6DDF | 6DDF_refined | 3.5 | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | - | - | - |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
peptide | Agonist | - | - | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | 55858 | |
Gi/o | αi1 | Human | - | 100 | β1 | Rat | γ2 | Bovine | cryo-EM | 6CMO | 6CMO_refined | 4.5 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | BRIL | Fab | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE | 10.1038/S41586-018-0215-Y | 2018-06-20 | 55858 | |
Gs | αs | Bovine | - | 57 | β1 | Rat | γ2 | Bovine | cryo-EM | 6NBH | - | 3.5 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTHrP, PTH, TIP39, PTHrP-(1-36) | peptide | Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | 55873 | |
Gi/o | αo | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6OIK | 6OIK_refined | 3.6 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | - | - | - |
iperoxo
pubchem
gtoplig
chembl_ligand
LY2119620 pubchem gtoplig chembl_ligand |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | 55864 | |
Gi/o | αi1 | Human | - | 100 | β1 | Human | γ2 | Human | cryo-EM | 6OT0 | - | 3.9 | SMO | SMO | Frizzled | F (Frizzled) | Human | - |
Fab light chain Fab heavy chain |
- |
24,25-Epoxy-cholesterol
pubchem
|
small-molecule | Agonist | - | - | Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X | 10.1038/S41586-019-1286-0 | 2019-06-12 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 6OS9 | 6OS9_refined | 3.0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | - | scFv16 | - |
JMV449
pubchem
gtoplig
chembl_ligand
|
peptide | Agonist | neuromedin N, neurotensin, large neurotensin, large neuromedin N | peptide | Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41586-019-1337-6 | 2019-07-10 | 55858 | |
Gi/o | αi1 | Human | - | 60 | β1 | Bovine | γT1 | Bovine | cryo-EM | 6QNO | 6QNO_refined | 4.4 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - |
Fab antibody fragment light chain Fab antibody fragment heavy chain |
- |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G | 10.7554/ELIFE.46041 | 2019-07-10 | 55858 | |
Gi/o | αt1 | Bovine | - | 64 | β1 | Bovine | γT1 | Bovine | cryo-EM | 6OY9 | 6OY9_refined | 3.9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Retinal (all-trans)
pubchem
|
small-molecule | Agonist | - | - | Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | 55968 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 6KPG | 6KPG_refined | 3.0 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
AM841
pubchem
gtoplig
|
small-molecule | Agonist | anandamide, 2-arachidonoylglycerol | small-molecule | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | 55858 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 6NWE | 6NWE_refined | 2.7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
B-Octylglucoside
pubchem
|
small-molecule | unknown | - | - | - | - | 2020-02-12 | 55968 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 6PB1 | 6PB1_refined | 2.8 | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | - | Nanobody-35 | - |
Urocortin
pubchem
|
peptide | Agonist | urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone | peptide | Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | 55856 | |
Gs | αs | Human | Mini-Gs | 61 | β1 | Human | γ2 | Human | cryo-EM | 6LI3 | 6LI3_refined | 3.3 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | 55856 | |
Gs | αs | Human | - | 57 | β1 | Rat | γ2 | Bovine | cryo-EM | 6LPB | 6LPB_refined | 3.9 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
[Ac-His1]PACAP-27
gtoplig
chembl_ligand
pubchem
|
peptide | Agonist | PHV, PHI, PACAP-38, PACAP-27, PHM, VIP | peptide | Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O | 10.1038/S41594-020-0386-8 | 2020-03-11 | 55856 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6M1I | 6M1I_refined | 3.5 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
[Ac-His1]PACAP-27
gtoplig
chembl_ligand
pubchem
|
peptide | Agonist | PHV, PHI, PACAP-38, PACAP-27, PHM, VIP | peptide | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 6LMK | 6LMK_refined | 3.7 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
peptide | Agonist | glucagon | peptide | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | 55856 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6UUS | 6UUS_refined | 2.4 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP3 |
- |
Adrenomedullin
pubchem
|
peptide | Agonist | - | - | - | - | 2020-04-01 | 55856 | |
Gi/o | αo | Human | - | 60 | β1 | Mouse | γ2 | Human | cryo-EM | 6K41 | - | 2.9 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | scFv | - |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | 55864 | |
Gi/o | αi1 | Human | - | 62 | β1 | Mouse | γ2 | Human | cryo-EM | 6K42 | - | 4.1 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | T4-Lysozyme | scFv | - |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 6VMS | 6VMS_refined | 3.8 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | T4-Lysozyme | scFv16 | - |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | dopamine | small-molecule | Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM | 10.1038/S41586-020-2379-5 | 2020-06-17 | 55858 | |
Gi/o | αt2 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 6PGS | 6PGS_refined | 2.9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Geraniol
pubchem
|
small-molecule | unknown | - | - | - | - | 2020-07-01 | 55988 | |
Gi/o | αt2 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 6PH7 | 6PH7_refined | 2.9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Nerol
pubchem
|
small-molecule | unknown | - | - | - | - | 2020-07-01 | 55988 | |
Gs | αs | Human | - | 57 | β1 | Human | γ2 | Human | cryo-EM | 6VCB | 6VCB_refined | 3.3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
glucagon-like peptide 1-(7-37)
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
LSN3160440 pubchem |
peptide small-molecule |
Agonist PAM |
glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jimenez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW | 10.1038/S41589-020-0589-7 | 2020-07-22 | 55856 | |
Gs | αs | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6WZG | 6WZG_refined | 2.3 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
SECRETIN
chembl_ligand
pubchem
|
protein | Agonist | VIP, secretin | peptide | Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | 55856 | |
Gi/o | αi1 | Human | - | 65 | β1 | Human | γ2 | Human | cryo-EM | 6LFO | 6LFO_refined | 3.4 | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
Interleukin-8
pubchem
|
protein | Agonist | CXCL7, CXCL5, CXCL8, CXCL3, CXCL6, CXCL1, CXCL2 | peptide | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | 55858 | |
Gs | αs | Human | - | 89 | β1 | Human | γ2 | Human | cryo-EM | 6X1A | 6X1A_refined | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
danuglipron
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D | 10.1101/2020.08.16.252585 | 2020-09-09 | 55856 | |
Gq/11 | αq | Human | Gq-Gi2-Gs chimera | 59 | β1 | Human | γ2 | Human | cryo-EM | 6WHA | 6WHA_refined | 3.4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | BRIL | scFv16 | - |
25-CN-NBOH
pubchem
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | 55866 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBK | 6XBK_refined | 3.2 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
Cholesterol
pubchem
|
small-molecule | Agonist | - | - | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 55858 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6XOX | 6XOX_refined | 3.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - |
scFv16 Nanobody-35 |
- |
LY3502970
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | - | - | 2020-11-18 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7CZ5 | 7CZ5_refined | 2.6 | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Somatoliberin
pubchem
|
peptide | Agonist | GHRH | peptide | Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-020-18945-0 | 2020-11-18 | 55856 | |
GPa1 family | αPa1 | strain ATCC 204508 / S288c | Two alpha subunits bound to STE2 dimer | 46 | STE4 | strain ATCC 204508 / S288c | γ | strain ATCC 204508 / S288c | cryo-EM | 7AD3 | - | 3.5 | STE2 | STE2 | STE2 | D1 (Ste2-like fungal pheromone) | strain ATCC 204508 / S288c | - | - | - |
Alpha-factor mating pheromone
pubchem
|
peptide | Agonist | - | - | Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG | 10.1038/S41586-020-2994-1 | 2020-12-09 | 55872 | |
Gs | αs | Human | - | 55 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7DHI | 7DHI_refined | 3.3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
small-molecule | Agonist | noradrenaline, Zn2+, (-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline | small-molecule | Deng X, Li N, Mguni D, Wang J, Yang Y | 10.1093/NSR/NWAA284 | 2020-12-16 | 55856 | |
Gi/o | αi1 | Human | - | 95 | β1 | Human | γT1 | Human | cryo-EM | 7L0Q | 7L0Q_refined | 4.3 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | neuromedin N, neurotensin | peptide | - | - | 2021-01-06 | 55858 | |
Gi/o | αi1 | Human | Non-canonical conformation | 95 | β1 | Human | γT1 | Human | cryo-EM | 7L0S | 7L0S_refined | 4.5 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | neuromedin N, neurotensin | peptide | - | - | 2021-01-06 | 55858 | |
Gi/o | αo | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7D76 | - | 3.1 | AGRG3 | ADGRG3 | ADGRG | B2 (Adhesion) | Human | - | - | - |
Beclomethasone
pubchem
|
small-molecule | Agonist | - | - | Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP | 10.1038/S41586-020-03083-W | 2021-02-03 | 55864 | |
Gs | αs | Human | Engineered G alpha | 58 | β1 | Human | γ2 | Human | cryo-EM | 7L1V | 7L1V_refined | 3.0 | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | - |
scFv16 Nanobody-51 |
- |
compound 1 [PMID: 33547286]
pubchem
gtoplig
|
small-molecule | Agonist | orexin-A, orexin-B | peptide | Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K | 10.1038/S41467-021-21087-6 | 2021-02-10 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7JV5 | 7JV5_refined | 3.0 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL1160787
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | 55856 | |
Gs | αs | Human | Engineered G alpha | 60 | β1 | Human | γ2 | Human | cryo-EM | 7JVQ | 7JVQ_refined | 3.0 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
apomorphine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7CKX | 7CKX_refined | 3.5 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
A77636
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7CKZ | 7CKZ_refined | 3.1 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
LY3154207 pubchem gtoplig chembl_ligand |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | 55856 | |
Gs | αs | Human | Engineered G alpha | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7LJC | - | 3.0 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL1160787
chembl_ligand
pubchem
LY3154207 pubchem gtoplig chembl_ligand |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D | 10.1101/2021.02.07.430101 | 2021-03-03 | 55856 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7CMU | 7CMU_refined | 3.0 | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | BRIL | scFv16 | - |
pramipexole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | dopamine | small-molecule | Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | 55858 | |
Gq/11 | αq | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 7DFL | 7DFL_refined | 3.3 | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | - | scFv16 | - |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
|
small-molecule | Agonist | histamine | small-molecule | - | - | 2021-03-31 | 55866 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7E2Y | 7E2Y_refined | 3.0 | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | - | - |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7E33 | 7E33_refined | 2.9 | 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | scFv16 | - |
BRL-54443
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7E32 | 7E32_refined | 2.9 | 5HT1D | 5-HT1D | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | scFv16 | - |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | 5-HT-moduline, 5-hydroxytryptamine | small-molecule | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-21 | 55858 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7CX2 | 7CX2_refined | 2.8 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
small-molecule | Agonist | PGI2, thromboxane A2, PGF2α, PGE2, PGD2, PGE1 | small-molecule | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7CX4 | 7CX4_refined | 2.9 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
evatanepag
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | PGI2, thromboxane A2, PGF2α, PGE2, PGD2, PGE1 | small-molecule | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7KH0 | 7KH0_refined | 2.8 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | - |
scFv16 Nanobody-35 |
- |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
peptide | Agonist | oxytocin, vasopressin | peptide | Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C | 10.1038/S41422-021-00483-Z | 2021-05-26 | 55856 | |
Gs | αs | Human | - | 61 | β1 | Rat | γ2 | Human | cryo-EM | 7MBX | 7MBX_refined | 2.0 | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL216166
chembl_ligand
pubchem
|
protein | Agonist | gastrin-17, CCK-8, CCK-39, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-33 | peptide | - | - | 2021-05-26 | 55856 | |
Gs | αs | Human | - | 54 | β1 | Human | γ2 | Human | cryo-EM | 7BB6 | 7BB6_refined | 4.2 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
peptide | Agonist | oxytocin, vasopressin | peptide | Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B | 10.1126/SCIADV.ABG5628 | 2021-06-02 | 55856 | |
Gi/o | αi3 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 7E9H | 7E9H_refined | 4.0 | GRM4 | mGlu4 | Metabotropic glutamate | C (Glutamate) | Human | - | scFv16 | - |
L-serine-O-phosphate
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
small-molecule | Agonist | L-glutamic acid, L-serine-O-phosphate | small-molecule | Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B | 10.1038/S41586-021-03495-2 | 2021-06-23 | 55860 | |
Gi/o | αi1 | Human | - | 62 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7O7F | 7O7F_refined | 3.2 | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | - |
Fab heavy chain Fab light chain |
- |
CCL5
gtoplig
|
peptide | Agonist | CCL8, CCL13, CCL16, CCL5, CCL14, CCL11, CCL3, CCL7, CCL2, CCL4 | peptide | Isaikina P, Tsai CJ, Dietz N, Pamula F, Grahl A, Goldie KN, Guixa-Gonzalez R, Branco C, Paolini-Bertrand M, Calo N, Cerini F, Schertler GFX, Hartley O, Stahlberg H, Maier T, Deupi X, Grzesiek S | 10.1126/SCIADV.ABG8685 | 2021-06-30 | 55858 | |
Gi/o | αi1 | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7MTS | 7MTS_refined | 3.2 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | - | - | - |
2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
pubchem
L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem |
small-molecule small-molecule |
Ago-PAM Agonist |
L-glutamic acid | small-molecule | Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03680-3 | 2021-07-07 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7F1Q | 7F1Q_refined | 2.9 | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | - | - | - |
CCL3
gtoplig
|
peptide | Agonist | CCL8, CCL13, CCL16, CCL5, CCL14, CCL11, CCL3, CCL7, CCL2, CCL4 | peptide | Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B | 10.1038/S41467-021-24438-5 | 2021-07-14 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EW1 | 7EW1_refined | 3.4 | S1PR5 | S1P5 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EW3 | - | 3.1 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
Sphingosine 1-phosphate
pubchem
|
lipid | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | 55858 | |
Gs | αs | Bovine | - | 91 | β1 | Rat | γ2 | Bovine | cryo-EM | 7FIG | - | 3.9 | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | - | Nanobody-35 | - |
Choriogonadotropin beta
gtoplig
Glycoprotein alpha gtoplig |
protein protein |
Agonist | hCG, LH | peptide | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | 55873 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6ORV | - | 3.0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
CHEMBL3950796
chembl_ligand
pubchem
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/s41586-019-1902-z | 2020-01-08 | 55856 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6P9X | 6P9X_refined | 2.9 | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | - | Nanobody-35 | - |
Corticoliberin
pubchem
|
peptide | Agonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | 55856 | |
Gs | αs | Human | - | 49 | β1 | Human | γ2 | Human | cryo-EM | 6P9Y | 6P9Y_refined | 3.0 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
[Ac-His1]PACAP-27
gtoplig
chembl_ligand
pubchem
|
peptide | Agonist | PHV, PHI, PACAP-38, PACAP-27, PHM, VIP | peptide | - | - | 2020-02-05 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 6KPF | 6KPF_refined | 2.9 | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]-7-methyloctanenitrile
pubchem
|
small-molecule | Agonist | anandamide, 2-arachidonoylglycerol | small-molecule | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | 55858 | |
Gs | αs | Human | Gs-Gi1 chimera | 58 | β1 | Human | γ2 | Human | cryo-EM | 6PB0 | 6PB0_refined | 3.0 | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | - | Nanobody-35 | - |
Urocortin
pubchem
|
peptide | Agonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | 55856 | |
Gi/o | αi1 | Human | - | 100 | β1 | Human | γ2 | Human | cryo-EM | 6PT0 | 6PT0_refined | 3.2 | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | - | scFv16 | - |
WIN55212-2
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | anandamide, 2-arachidonoylglycerol | small-molecule | Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ | 10.1016/J.CELL.2020.01.007 | 2020-02-12 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6OMM | 6OMM_refined | 3.2 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | - | - | - |
CHEMBL552527
chembl_ligand
pubchem
|
protein | Agonist | 15-deoxy-LXA4, annexin I, fMet-Leu-Phe, PrP106-126, LTC4, resolvin D1, LL-37, LXA4, aspirin-triggered resolvin D1, humanin, aspirin triggered lipoxin A4, serum amyloid A, LTD4 | peptide | Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C | 10.1038/S41467-020-14728-9 | 2020-02-26 | 55858 | |
Gs | αs | Human | - | 54 | β1 | Human | γ2 | Human | cryo-EM | 6M1H | 6M1H_refined | 3.6 | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | - | Nanobody-35 | - |
maxadilan
gtoplig
pubchem
|
peptide | Agonist | PHV, PHI, PACAP-38, PACAP-27, PHM, VIP | peptide | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | 55856 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6UUN | 6UUN_refined | 3.0 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP2 |
- |
Adrenomedullin
pubchem
|
peptide | Agonist | - | - | - | - | 2020-03-25 | 55856 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 6LML | 6LML_refined | 3.9 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | scFv16 | - |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
peptide | Agonist | glucagon | peptide | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | 55858 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 6UVA | 6UVA_refined | 2.3 | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP3 |
- |
adrenomedullin 2/intermedin
gtoplig
|
peptide | Agonist | - | - | - | - | 2020-04-01 | 55856 | |
Gs | αs | Human | - | 56 | β1 | Human | γ2 | Human | cryo-EM | 6WHC | 6WHC_refined | 3.4 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Dual-agonist peptide P15
|
peptide | Agonist | glucagon | peptide | Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM | 10.1074/JBC.RA120.013793 | 2020-05-27 | 55856 | |
Gi/o | αt1 | Bovine | Only H5 | 3 | - | - | - | - | X-ray | 6PEL | 6PEL_refined | 3.2 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | - | - | - |
Citronellol
pubchem
|
small-molecule | unknown | - | - | - | - | 2020-06-24 | 55968 | |
Gi/o | αo | Human | - | 59 | β1 | Rat | γ2 | Mouse | cryo-EM | 6WWZ | 6WWZ_refined | 3.3 | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
CCL20
gtoplig
|
peptide | Agonist | beta-defensin 4A, CCL20 | peptide | Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H | 10.1038/S41467-020-16820-6 | 2020-06-24 | 55864 | |
Gs | αs | Human | - | 48 | β1 | Human | γ2 | Human | cryo-EM | 7C2E | 7C2E_refined | 4.2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid
pubchem
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE | 10.1038/S41422-020-0384-8 | 2020-08-26 | 55856 | |
Gs | αs | Human | - | 56 | β1 | Rat | γ2 | Bovine | cryo-EM | 7BW0 | 7BW0_refined | 3.9 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | BRIL | Nanobody-35 | - | - | - | - | deoxycholic acid, cholic acid, chenodeoxycholic acid, lithocholic acid | small-molecule | Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R | 10.1038/S41392-020-00262-Z | 2020-09-02 | 55856 | |
Gs | αs | Bovine | - | 51 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7JJO | 7JJO_refined | 2.6 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | - | Nanobody-35 | - |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
small-molecule | Agonist | - | - | Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY | 10.1016/J.MOLCEL.2020.08.001 | 2020-09-02 | 55873 | |
Gs | αs | Human | - | 89 | β1 | Human | γ2 | Human | cryo-EM | 6X19 | 6X19_refined | 2.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
CHU-128
pubchem
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D | 10.1101/2020.08.16.252585 | 2020-09-09 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7CFM | 7CFM_refined | 3.0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL2331646
chembl_ligand
pubchem
|
small-molecule | Agonist | deoxycholic acid, cholic acid, chenodeoxycholic acid, lithocholic acid | small-molecule | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | 55856 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 6XBL | 6XBL_refined | 3.9 | SMO | SMO | Frizzled | F (Frizzled) | Human | - | scFv16 | - |
Cholesterol
pubchem
SAG1.3 pubchem gtoplig |
small-molecule small-molecule |
Agonist PAM |
- | - | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | 55858 | |
Gs | αs | Human | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7D3S | 7D3S_refined | 2.9 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
SECRETIN
chembl_ligand
pubchem
|
protein | Agonist | VIP, secretin | peptide | Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O | 10.1016/J.BBRC.2020.08.042 | 2020-11-04 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7D7M | 7D7M_refined | 3.3 | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
small-molecule | Agonist | PGI2, thromboxane A2, PGF2α, PGE2, PGD2, PGE1 | small-molecule | - | - | 2020-11-18 | 55856 | |
Gs | αs | Bovine | - | 57 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7D68 | 7D68_refined | 3.0 | GLP2R | GLP-2 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
peptide | Agonist | glucagon-like peptide 2, glucagon-like peptide 2-(3-33) | peptide | Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW | 10.1038/S41422-020-00442-0 | 2020-12-16 | 55873 | |
Gs | αs | Human | - | 49 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7DHR | 7DHR_refined | 3.8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | - | Nanobody-35 | - |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, Zn2+, (-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline | small-molecule | Deng X, Li N, Mguni D, Wang J, Yang Y | 10.1093/NSR/NWAA284 | 2020-12-16 | 55856 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γT1 | Human | cryo-EM | 7L0P | 7L0P_refined | 4.1 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | neuromedin N, neurotensin | peptide | - | - | 2021-01-06 | 55858 | |
Gi/o | αi1 | Human | Non-canonical conformation | 63 | β1 | Human | γT1 | Human | cryo-EM | 7L0R | 7L0R_refined | 4.2 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | - | - | - |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | neuromedin N, neurotensin | peptide | - | - | 2021-01-06 | 55858 | |
Gs | αs | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7LCI | 7LCI_refined | 2.9 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | - | - |
danuglipron
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | - | - | 2021-01-20 | 55856 | |
Gi/o | αo | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7D77 | 7D77_refined | 2.9 | AGRG3 | ADGRG3 | ADGRG | B2 (Adhesion) | Human | - | scFv16 | - |
HYDROCORTISONE
chembl_ligand
pubchem
|
small-molecule | Agonist | - | - | Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP | 10.1038/S41586-020-03083-W | 2021-02-03 | 55864 | |
Gs | αs | Human | Engineered G alpha | 58 | β1 | Human | γ2 | Human | cryo-EM | 7L1U | 7L1U_refined | 3.2 | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | - | scFv16 | - |
Orexin-A
pubchem
|
peptide | Agonist | orexin-A, orexin-B | peptide | Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K | 10.1038/S41467-021-21087-6 | 2021-02-10 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7JVP | 7JVP_refined | 2.9 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
39YLC3L0ZU
pubchem
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | 55856 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 7JVR | 7JVR_refined | 2.8 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | - | scFv16 | - |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | dopamine | small-molecule | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | 55858 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7CKW | 7CKW_refined | 3.2 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
fenoldopam
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
gtoplig
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7CKY | 7CKY_refined | 3.2 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL3697578
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7CRH | 7CRH_refined | 3.3 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL1416789
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | 55856 | |
Gs | αs | Human | Engineered G alpha | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7LJD | - | 3.2 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
LY3154207 pubchem gtoplig chembl_ligand |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D | 10.1101/2021.02.07.430101 | 2021-03-03 | 55856 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7CMV | 7CMV_refined | 2.7 | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | BRIL | scFv16 | - |
CHEMBL70565
chembl_ligand
chembl_ligand
pubchem
|
small-molecule | Agonist | dopamine | small-molecule | Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7E2X | 7E2X_refined | 3.0 | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | 5-hydroxytryptamine | small-molecule | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7E2Z | 7E2Z_refined | 3.1 | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | - | - | - |
aripiprazole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist (partial) | 5-hydroxytryptamine | small-molecule | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | 55858 | |
Gs | αs | Human | - | 86 | β1 | Human | γ2 | Human | X-ray | 7JOZ | 7JOZ_refined | 3.8 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | - | Nanobody-35 | - |
CHEMBL4453318
chembl_ligand
pubchem
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, 5-hydroxytryptamine, (-)-noradrenaline, dopamine | small-molecule | - | - | 2021-04-14 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7AUE | 7AUE_refined | 3.0 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | scFv16 | - |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
peptide | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY, Shalev-Benami M | 10.1126/SCIENCE.ABF7958 | 2021-04-28 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7CX3 | 7CX3_refined | 2.8 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | - | Nanobody-35 | - |
taprenepag
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | PGI2, thromboxane A2, PGF2α, PGE2, PGD2, PGE1 | small-molecule | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | 55856 | |
Gi/o | αi1 | Human | - | 99 | β1 | Human | γ2 | Human | cryo-EM | 7EB2 | 7EB2_refined | 3.5 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | - | scFv16 | - |
(-)-baclofen
pubchem
gtoplig
chembl_ligand
drugbank
drugbank
gtoplig
pubchem
BHFF pubchem |
small-molecule small-molecule |
Agonist PAM |
- | - | Shen C, Mao C, Xu C, Jin N, Zhang H, Shen DD, Shen Q, Wang X, Hou T, Chen Z, Rondard P, Pin JP, Zhang Y, Liu J | 10.1038/S41586-021-03507-1 | 2021-05-05 | 55858 | |
Gq/11 | αq | Human | Gq-Gs-Gi1 chimera | 55 | β1 | Rat | γ2 | Human | cryo-EM | 7MBY | 7MBY_refined | 2.4 | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | - | - | - |
CHEMBL216166
chembl_ligand
pubchem
|
protein | Agonist | gastrin-17, CCK-8, CCK-39, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-33 | peptide | - | - | 2021-05-26 | 55866 | |
Gs | αs | Human | - | 55 | β1 | Human | γ2 | Human | cryo-EM | 7BB7 | 7BB7_refined | 4.4 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
peptide | Agonist | oxytocin, vasopressin | peptide | Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B | 10.1126/SCIADV.ABG5628 | 2021-06-02 | 55856 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 7E9G | 7E9G_refined | 3.5 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | - | scFv16 | DN13 |
eglumegad
pubchem
gtoplig
chembl_ligand
gtoplig
JNJ-40411813 pubchem gtoplig chembl_ligand drugbank |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B | 10.1038/S41586-021-03495-2 | 2021-06-23 | 55858 | |
Gs | αs | Human | - | 48 | β1 | Bovine | γ2 | Mouse | cryo-EM | 7E14 | 7E14_refined | 2.9 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
pubchem
LY3502970 pubchem gtoplig chembl_ligand |
small-molecule small-molecule |
Ago-PAM Agonist |
glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-07-07 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7JHJ | 7JHJ_refined | 3.2 | Q3KSP2 | BILF1 | Unclassified | A (Rhodopsin) | strain GD1 | - | scFv16 | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC | 10.1016/J.IMMUNI.2021.06.001 | 2021-07-07 | 55858 | |
Gs | αs | Human | - | 61 | β1 | Rat | γ2 | Bovine | cryo-EM | 7DUQ | 7DUQ_refined | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
pubchem
CHEMBL410972 chembl_ligand pubchem pubchem |
small-molecule protein |
Ago-PAM Agonist |
glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-07-14 | 55856 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7F1R | 7F1R_refined | 3.0 | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | - | - | - |
CCL5
gtoplig
|
peptide | Agonist | CCL8, CCL13, CCL16, CCL5, CCL14, CCL11, CCL3, CCL7, CCL2, CCL4 | peptide | Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B | 10.1038/S41467-021-24438-5 | 2021-07-14 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7F1S | 7F1S_refined | 2.8 | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | CCL8, CCL13, CCL16, CCL5, CCL14, CCL11, CCL3, CCL7, CCL2, CCL4 | peptide | Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B | 10.1038/S41467-021-24438-5 | 2021-07-14 | 55858 | |
Gs | αs | Human | - | 56 | β1 | Rat | γ2 | Bovine | cryo-EM | 7DW9 | - | 2.6 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | - |
Nanobody-35 scFv16 |
- |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
peptide | Agonist | oxytocin, vasopressin | peptide | Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, He X, Zhang X, Yang D, Wang P, Xu HE, Wang MW, Jiang Y | 10.1038/S41422-021-00480-2 | 2021-07-21 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Rat | γ2 | Bovine | cryo-EM | 7DH5 | 7DH5_refined | 3.2 | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | - | Nanobody-35 | - |
mirabegron
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | - | - | Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O | 10.1016/J.MOLCEL.2021.06.024 | 2021-08-04 | 55856 | |
Gs | αs | Bovine | - | 59 | β1 | Rat | γ2 | Bovine | cryo-EM | 7DTY | 7DTY_refined | 3.0 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
GIP
pubchem
|
small-molecule | Agonist | gastric inhibitory polypeptide | peptide | Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW | 10.7554/ELIFE.68719 | 2021-08-04 | 55873 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7EVW | - | 3.2 | FZD7 | FZD7 | Frizzled | F (Frizzled) | Human | - | Nanobody-35 | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F | 10.1038/S41422-021-00525-6 | 2021-08-04 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7EXD | 7EXD_refined | 3.4 | 5HT1F | 5-HT1F | 5-Hydroxytryptamine | A (Rhodopsin) | Human | BRIL | scFv16 | - |
lasmiditan
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | Huang S, Xu P, Tan Y, You C, Zhang Y, Jiang Y, Xu HE | 10.1038/S41422-021-00527-4 | 2021-08-04 | 55858 | |
Gs | αs | Human | - | 53 | β1 | Human | γ2 | Human | cryo-EM | 7KI0 | - | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
semaglutide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | 55856 | |
Gs | αs | Human | - | 89 | β1 | Human | γ2 | Human | cryo-EM | 7KI1 | 7KI1_refined | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Taspoglutide
pubchem
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Rat | γ2 | Bovine | cryo-EM | 7DUR | 7DUR_refined | 3.3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
pubchem
|
small-molecule | Ago-PAM | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-08-11 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Rat | γ2 | Bovine | cryo-EM | 7EVM | 7EVM_refined | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
pubchem
|
small-molecule | Ago-PAM | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-08-11 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Rat | γ2 | Bovine | cryo-EM | 7DB6 | 7DB6_refined | 3.3 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | - | scFv16 | - |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | melatonin | small-molecule | Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N, Kobayashi T, Iwata S, Nishizawa T, Nureki O | 10.1038/S41594-021-00634-1 | 2021-08-18 | 55858 | |
Gs | αs | Human | - | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7F16 | 7F16_refined | 2.8 | PTH2R | PTH2 | Parathyroid hormone | B1 (Secretin) | Human | - | Nanobody-35 | - |
TIP39
gtoplig
|
peptide | Agonist | PTH, PTHrP, PTHrP-(1-36), PTHrP-(1-34) (human), TIP39 | peptide | Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW | 10.1073/PNAS.2101279118 | 2021-08-18 | 55856 | |
Gq/11 | αq | Human | Engineered G alpha | 59 | β1 | Human | γ2 | Human | cryo-EM | 7F9Y | 7F9Y_refined | 2.9 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
ghrelin
gtoplig
|
peptide | Agonist | ghrelin, [des-Gln14]ghrelin | peptide | - | - | 2021-08-18 | 55866 | |
Gq/11 | αq | Human | Engineered G alpha | 59 | β1 | Human | γ2 | Human | cryo-EM | 7F9Z | 7F9Z_refined | 3.2 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | - |
Nanobody-35 scFv16 |
- |
GHRP-6
pubchem
gtoplig
|
peptide | Agonist | ghrelin, [des-Gln14]ghrelin | peptide | - | - | 2021-08-18 | 55866 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7EZH | 7EZH_refined | 3.2 | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | - | scFv16 | - |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
peptide | Agonist | gastrin-17, CCK-8, CCK-39, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-33 | peptide | - | - | 2021-08-25 | 55858 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7EZK | 7EZK_refined | 3.1 | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | - | - | - |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
peptide | Agonist | gastrin-17, CCK-8, CCK-39, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-33 | peptide | - | - | 2021-08-25 | 55856 | |
Gq/11 | αq | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 7EZM | - | 2.9 | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | - | scFv16 | - |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
peptide | Agonist | gastrin-17, CCK-8, CCK-39, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-33 | peptide | - | - | 2021-08-25 | 55866 | |
Gi/o | αi2 | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7LD3 | 7LD3_refined | 3.2 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | - | - | - |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone pubchem |
small-molecule small-molecule |
Agonist PAM |
adenosine | small-molecule | - | - | 2021-09-08 | 55859 | |
Gi/o | αi2 | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7LD4 | 7LD4_refined | 3.3 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | - | - | - |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | adenosine | small-molecule | - | - | 2021-09-08 | 55859 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EW2 | 7EW2_refined | 3.1 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EW4 | - | 3.2 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
CYM-5541
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | 55858 | |
Gs | αs | Bovine | - | 56 | β1 | Rat | γ2 | Bovine | cryo-EM | 7FIH | - | 3.2 | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | - | - | - |
Choriogonadotropin beta
gtoplig
Glycoprotein alpha gtoplig 5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide pubchem |
protein protein small-molecule |
Agonist | hCG, LH | peptide | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | 55873 | |
Gq/11 | αq | Human | Gq-Gi1 chimera | 62 | β1 | Human | γ2 | Human | cryo-EM | 7F8W | 7F8W_refined | 3.1 | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | - | scFv16 | - |
desulfated gastrin-17
pubchem
gtoplig
chembl_ligand
pubchem
|
peptide | Agonist | gastrin-17, desulfated gastrin-34, CCK-8, gastrin-34, CCK-39, desulfated cholecystokinin-8, gastrin-14, CCK-4, desulfated gastrin-17, desulfated gastrin-14, CCK-58, gastrin-71, desulfated gastrin-71, CCK-33 | peptide | - | - | 2021-10-13 | 55866 | |
Gi/o | αi2 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7F8V | 7F8V_refined | 3.3 | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | - | - | - |
desulfated gastrin-17
pubchem
gtoplig
chembl_ligand
pubchem
|
peptide | Agonist | gastrin-17, desulfated gastrin-34, CCK-8, gastrin-34, CCK-39, desulfated cholecystokinin-8, gastrin-14, CCK-4, desulfated gastrin-17, desulfated gastrin-14, CCK-58, gastrin-71, desulfated gastrin-71, CCK-33 | peptide | - | - | 2021-10-13 | 55859 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7F55 | 7F55_refined | 3.1 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
bremelanotide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
peptide | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | None | 10.1038/S41422-021-00552-3 | 2021-11-03 | 55856 | |
Gs | αs | Human | - | 46 | β1 | Rat | γ2 | Mouse | cryo-EM | 7PIV | 7PIV_refined | 2.9 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
afamelanotide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
pubchem
pubchem
pubchem
|
peptide | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | - | - | 2021-11-17 | 55856 | |
Gs | αs | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7RTB | 7RTB_refined | 2.1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Peptide-19
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | None | 10.1016/J.BBRC.2021.09.016 | 2021-10-06 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7S8O | 7S8O_refined | 2.6 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | BRIL | scFv16 | - |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | PAMP-20 | peptide | - | - | 2021-11-17 | 55858 | |
Gq/11 | αq | Human | Gq-Gi1 chimera | 61 | β1 | Rat | γ2 | Bovine | cryo-EM | 7EIB | 7EIB_refined | 3.0 | BKRB1 | B1 | Bradykinin | A (Rhodopsin) | Human | - | - | - |
[des-Arg10]kallidin
pubchem
gtoplig
chembl_ligand
gtoplig
|
peptide | Agonist | Lys-[Hyp3]-bradykinin, bradykinin, T-kinin, [des-Arg9]bradykinin, [Hyp3]bradykinin, [des-Arg10]kallidin, kallidin | peptide | None | 10.1038/S41594-021-00645-Y | 2021-10-13 | 55866 | |
Gs | αs | Human | - | 55 | β1 | Human | γ2 | Human | cryo-EM | 7RMH | 7RMH_refined | 3.1 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | substance P, neurokinin A, neuropeptide-γ, neuropeptide K, neurokinin B, hemokinin 1 | peptide | None | 10.1038/S41589-021-00890-8 | 2021-11-03 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7F58 | 7F58_refined | 3.1 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
THIQ
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | - | - | 2021-11-03 | 55856 | |
Gq/11 | αq | Human | Gq-Gs chimera | 57 | β1 | Human | γ2 | Human | cryo-EM | 7S8L | 7S8L_refined | 2.5 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
Cortistatin 14
pubchem
|
peptide | Agonist | PAMP-20 | peptide | - | - | 2021-11-17 | 55866 | |
Gs | αs | Human | Gs-Gq chimera | 49 | β1 | Human | γ2 | Human | cryo-EM | 7RMG | 7RMG_refined | 3.0 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | substance P, neurokinin A, neuropeptide-γ, neuropeptide K, neurokinin B, hemokinin 1 | peptide | - | - | 2021-11-03 | 55856 | |
Gs | αs | Bovine | - | 91 | β1 | Rat | γ2 | Bovine | cryo-EM | 7FII | - | 4.3 | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | - | - | - |
Choriogonadotropin beta
gtoplig
Glycoprotein alpha gtoplig |
protein protein |
Agonist | hCG, LH | peptide | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | 55873 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7F54 | 7F54_refined | 3.0 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
afamelanotide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
pubchem
pubchem
pubchem
|
peptide | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | - | - | 2021-11-03 | 55856 | |
Gs | αs | Human | Gs-Gq chimera | 49 | β1 | Human | γ2 | Human | cryo-EM | 7RMI | 7RMI_refined | 3.2 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | substance P, neurokinin A, neuropeptide-γ, neuropeptide K, neurokinin B, hemokinin 1 | peptide | - | - | 2021-11-03 | 55856 | |
Gq/11 | αq | Human | Gq-Gs chimera | 57 | β1 | Human | γ2 | Human | cryo-EM | 7S8N | 7S8N_refined | 2.9 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | PAMP-20 | peptide | - | - | 2021-11-17 | 55866 | |
Gq/11 | αq | Human | Gq-Gs chimera | 57 | β1 | Human | γ2 | Human | cryo-EM | 7S8P | 7S8P_refined | 2.6 | MRGX4 | MRGPRX4 | A orphans | A (Rhodopsin) | Human | BRIL | scFv16 | - |
N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine
pubchem
|
small-molecule | Agonist | - | - | - | - | 2021-11-17 | 55866 | |
Gq/11 | αq | Human | Gq-Gi1 chimera | 60 | β1 | Rat | γ2 | Bovine | cryo-EM | 7F2O | 7F2O_refined | 2.9 | BKRB2 | B2 | Bradykinin | A (Rhodopsin) | Human | - | scFv16 | - |
bradykinin
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
peptide | Agonist | Lys-[Hyp3]-bradykinin, bradykinin, T-kinin, [des-Arg9]bradykinin, [Hyp3]bradykinin, [des-Arg10]kallidin, kallidin | peptide | - | - | 2021-10-13 | 55866 | |
Gs | αs | Human | - | 48 | β1 | Rat | γ2 | Bovine | cryo-EM | 7PIU | - | 2.6 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
peptide | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P | 10.1038/S41422-021-00569-8 | 2021-11-17 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7F53 | 7F53_refined | 3.0 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
α-MSH
pubchem
gtoplig
|
peptide | Agonist | agouti-related protein, α-MSH, ACTH, β-MSH, γ-MSH | peptide | - | - | 2021-11-03 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7S8M | 7S8M_refined | 2.5 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | BRIL | scFv16 | - |
Cortistatin 14
pubchem
|
peptide | Agonist | PAMP-20 | peptide | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7VDH | 7VDH_refined | 2.9 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
compound 48/80
pubchem
gtoplig
|
small-molecule | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7VDL | 7VDL_refined | 3.2 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
Cortistatin 14
pubchem
|
peptide | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7VDM | 7VDM_refined | 3.0 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7VUY | - | 2.8 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
PAMP-12
pubchem
|
peptide | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7VUZ | - | 2.9 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
PAMP-12
pubchem
|
peptide | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7VV3 | - | 3.0 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
Cortistatin 14
pubchem
|
peptide | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7VV5 | 7VV5_refined | 2.8 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | - | scFv16 | - |
compound 48/80
pubchem
gtoplig
|
small-molecule | Agonist | PAMP-20 | peptide | - | - | 2021-12-01 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7NA7 | 7NA7_refined | 2.7 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | - | Antibody fragment | - |
Ghrelin-27
|
peptide | Agonist | ghrelin, [des-Gln14]ghrelin | peptide | Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C | 10.1038/S41467-021-26735-5 | 2021-12-15 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7NA8 | 7NA8_refined | 2.7 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | - | Antibody fragment | - |
ibutamoren
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | ghrelin, [des-Gln14]ghrelin | peptide | Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C | 10.1038/S41467-021-26735-5 | 2021-12-15 | 55858 | |
Gq/11 | αq | Human | Gq-Gs-Gi1 chimera | 59 | β1 | Human | γ2 | Human | cryo-EM | 7P00 | 7P00_refined | 2.7 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | - | scFv16 | - |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | substance P, neurokinin A, neuropeptide-γ, neuropeptide K, neurokinin B, hemokinin 1 | peptide | Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A | 10.1126/SCIADV.ABK2872 | 2021-12-15 | 55866 | |
Gs | αs | Human | Gs-Gi1 chimera | 57 | β1 | Human | γ2 | Human | cryo-EM | 7P02 | 7P02_refined | 2.9 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | - | scFv16 | - |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
peptide | Agonist | substance P, neurokinin A, neuropeptide-γ, neuropeptide K, neurokinin B, hemokinin 1 | peptide | Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A | 10.1126/SCIADV.ABK2872 | 2021-12-15 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7VUG | 7VUG_refined | 3.2 | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | - | scFv16 | Xylanase |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | L-phenylalanine, L-tryptophan | small-molecule | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | 55858 | |
Gs | αs | Human | - | 57 | β1 | Human | γ2 | Human | cryo-EM | 7VUI | - | 3.3 | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | - | Nanobody-35 | Xylanase |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | L-phenylalanine, L-tryptophan | small-molecule | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7VUH | - | 3.2 | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | - | Nanobody-35 | Xylanase |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | L-phenylalanine, L-tryptophan | small-molecule | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7VUJ | - | 3.8 | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | - | Nanobody-35 | Xylanase |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | L-phenylalanine, L-tryptophan | small-molecule | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7S1M | 7S1M_refined | 2.4 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
exendin-4
pubchem
gtoplig
pubchem
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH | 10.1038/S41589-021-00945-W | 2022-01-05 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7S3I | - | 2.5 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
exendin-4
pubchem
gtoplig
pubchem
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH | 10.1038/S41589-021-00945-W | 2022-01-05 | 55856 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7EO2 | 7EO2_refined | 2.9 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | 55858 | |
Gi/o | αi1 | Human | - | 43 | β1 | Human | γ2 | Human | cryo-EM | 7EO4 | 7EO4_refined | 2.9 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | 55858 | |
Gi/o | αi1 | Human | - | 40 | β1 | Human | γ2 | Human | cryo-EM | 7WF7 | 7WF7_refined | 3.4 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
sphingosine 1-phosphate
pubchem
gtoplig
chembl_ligand
pubchem
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | 55858 | |
Gi/o | αo | Human | - | 60 | β1 | Human | γ2 | Human | cryo-EM | 7W2Z | 7W2Z_refined | 2.8 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | - | scFv16 | - |
Ghrelin
pubchem
|
peptide | Agonist | ghrelin, [des-Gln14]ghrelin | peptide | Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z | 10.1038/S41467-022-27975-9 | 2022-01-19 | 55864 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7LLL | 7LLL_refined | 3.7 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
exendin-4
pubchem
gtoplig
pubchem
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D | 10.1038/S41467-021-27760-0 | 2022-01-12 | 55856 | |
Gs | αs | Human | - | 50 | β1 | Human | γ2 | Human | cryo-EM | 7LLY | 7LLY_refined | 3.3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Pro-glucagon
pubchem
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D | 10.1038/S41467-021-27760-0 | 2022-01-12 | 55856 | |
Gq/11 | α11 | Human | - | 96 | β1 | Human | γ2 | Human | cryo-EM | 7RKF | - | 4.0 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | - | scFv16 | - |
Fractalkine
pubchem
|
peptide | Agonist | - | - | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | 55867 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7RKM | 7RKM_refined | 3.5 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | - | scFv16 | - |
Fractalkine
pubchem
|
peptide | Agonist | - | - | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 | Human | cryo-EM | 7RKN | 7RKN_refined | 3.6 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | - | scFv16 | - |
Fractalkine
pubchem
|
peptide | Agonist | - | - | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | 55858 | |
Gs | αs | Human | - | 57 | β1 | Rat | γ2 | Bovine | cryo-EM | 7V9M | 7V9M_refined | 3.3 | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Somatoliberin
pubchem
|
peptide | Agonist | GHRH | peptide | - | - | 2021-10-20 | 55856 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EVY | 7EVY_refined | 3.0 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EVZ | 7EVZ_refined | 3.1 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
cenerimod
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EW0 | 7EW0_refined | 3.4 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
ozanimod
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7EW7 | 7EW7_refined | 3.3 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | scFv16 | - |
SEW2871
pubchem
gtoplig
chembl_ligand
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | 55858 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7F4D | 7F4D_refined | 3.0 | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
INTERMEDINE
chembl_ligand
pubchem
pubchem
pubchem
|
protein | Agonist | α-MSH, ACTH, γ-MSH, β-MSH | peptide | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7F4F | 7F4F_refined | 2.9 | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | - | scFv16 | - |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
protein | Agonist | α-MSH, ACTH, γ-MSH, β-MSH | peptide | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7F4H | 7F4H_refined | 2.7 | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | - |
Nanobody-35 scFv16 |
- |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
protein | Agonist | α-MSH, ACTH, γ-MSH, β-MSH | peptide | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7F4I | 7F4I_refined | 3.1 | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | - | Nanobody-35 | - |
bremelanotide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
peptide | Agonist | α-MSH, ACTH, γ-MSH, β-MSH | peptide | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | 55856 | |
Gi/o | αi1 | Human | - | 61 | β1 | Rat | γ2 | Bovine | cryo-EM | 7T6T | 7T6T_refined | 3.2 | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | - | - | - |
synthetic peptide
|
peptide | Agonist | cathepsin G, spinorphin, annexin I, fMet-Leu-Phe | peptide | - | - | 2022-03-30 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Rat | γ2 | Bovine | cryo-EM | 7T6S | 7T6S_refined | 3.0 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | - | scFv16 | - |
N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea
pubchem
|
small-molecule | Agonist | 15-deoxy-LXA4, annexin I, fMet-Leu-Phe, PrP106-126, LTC4, resolvin D1, LL-37, LXA4, aspirin-triggered resolvin D1, humanin, aspirin triggered lipoxin A4, serum amyloid A, LTD4 | peptide | - | - | 2022-03-30 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Rat | γ2 | Bovine | cryo-EM | 7T6U | 7T6U_refined | 2.9 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | - | - | - |
synthetic peptide
|
peptide | Agonist | 15-deoxy-LXA4, annexin I, fMet-Leu-Phe, PrP106-126, LTC4, resolvin D1, LL-37, LXA4, aspirin-triggered resolvin D1, humanin, aspirin triggered lipoxin A4, serum amyloid A, LTD4 | peptide | - | - | 2022-03-30 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Rat | γ2 | Bovine | cryo-EM | 7T6V | 7T6V_refined | 3.1 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | - | scFv16 | - |
synthetic peptide
|
peptide | Agonist | 15-deoxy-LXA4, annexin I, fMet-Leu-Phe, PrP106-126, LTC4, resolvin D1, LL-37, LXA4, aspirin-triggered resolvin D1, humanin, aspirin triggered lipoxin A4, serum amyloid A, LTD4 | peptide | - | - | 2022-03-30 | 55858 | |
Gi/o | αi1 | Human | - | 63 | β1 | Human | γ2 | Human | cryo-EM | 7VGX | 7VGX_refined | 3.2 | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | - | scFv16 | - |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
peptide | Agonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | Park C, Kim J, Ko SB, Choi YK, Jeong H, Woo H, Kang H, Bang I, Kim SA, Yoon TY, Seok C, Im W, Choi HJ | 10.1038/S41467-022-28510-6 | 2022-02-23 | 55858 | |
Gi/o | αi3 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7T10 | 7T10_refined | 2.5 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | - | scFv16 | - |
SOMATOSTATIN
chembl_ligand
pubchem
|
protein | Agonist | cortistatin-14, SRIF-28, CST-17, SRIF-14 | peptide | Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G | 10.1038/S41594-022-00727-5 | 2022-03-09 | 55860 | |
Gi/o | αi3 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7T11 | 7T11_refined | 2.7 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | - | scFv16 | - |
Octreotide
|
peptide | Agonist | cortistatin-14, SRIF-28, CST-17, SRIF-14 | peptide | Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G | 10.1038/S41594-022-00727-5 | 2022-03-09 | 55860 | |
Gq/11 | αq | Human | Gamma subunit fused to alpha subunit | 57 | β1 | Human | - | - | cryo-EM | 7RYC | - | 2.9 | OXYR | OT | Vasopressin and oxytocin | A (Rhodopsin) | Human | - | scFv16 | - |
oxytocin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
peptide | Agonist | oxytocin, vasopressin | peptide | Meyerowitz JG, Robertson MJ, Barros-Alvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G | 10.1038/S41594-022-00728-4 | 2022-03-09 | 55866 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7VL8 | 7VL8_refined | 2.9 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
Apo (no ligand)
|
none | Apo (no ligand) | CCL8, CCL13, CCL16, CCL5, CCL15, CCL14, CCL23, CCL3, CCL7, CCL4 | peptide | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Human | γ2 | Human | cryo-EM | 7VL9 | 7VL9_refined | 2.6 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
CCL15(26-92)
|
peptide | Agonist | CCL8, CCL13, CCL16, CCL5, CCL15, CCL14, CCL23, CCL3, CCL7, CCL4 | peptide | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7VLA | 7VLA_refined | 2.7 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | - | scFv16 | - |
CCL15(27-92)
|
peptide | Agonist | CCL8, CCL13, CCL16, CCL5, CCL15, CCL14, CCL23, CCL3, CCL7, CCL4 | peptide | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | 55858 | |
Gi/o | αi1 | Human | - | 64 | β1 | Human | γ2 | Human | cryo-EM | 7VKT | 7VKT_refined | 2.9 | LT4R1 | BLT1 | Leukotriene | A (Rhodopsin) | Human | - | scFv16 | - |
LTB4
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | 12R-HETE, 20-hydroxy-LTB4, LTB4 | small-molecule | Wang N, He X, Zhao J, Jiang H, Cheng X, Xia Y, Eric Xu H, He Y | 10.1038/S41467-022-28820-9 | 2022-03-09 | 55858 | |
Gi/o | αi1 | Mouse | - | 62 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7TD0 | 7TD0_refined | 2.8 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | - | - | - |
(2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate
pubchem
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | 55900 | |
Gi/o | αi1 | Mouse | - | 62 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7TD1 | 7TD1_refined | 3.1 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | - | - | - |
(2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate
pubchem
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | 55900 | |
Gi/o | αi1 | Mouse | - | 62 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7TD2 | 7TD2_refined | 3.1 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | - | - | - |
(2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate
pubchem
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | 55900 | |
Gi/o | αi1 | Mouse | - | 63 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7TD3 | 7TD3_refined | 3.0 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | - | - |
sphingosine 1-phosphate
pubchem
gtoplig
chembl_ligand
pubchem
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | 55900 | |
Gi/o | αi1 | Mouse | - | 63 | β1 | Bovine | γ2 | Bovine | cryo-EM | 7TD4 | 7TD4_refined | 2.6 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | - | - | - |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
small-molecule | Agonist | sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | 55900 | |
Gi/o | αi1 | Human | - | 62 | β1 | Rat | γ2 | Bovine | cryo-EM | 7VGZ | 7VGZ_refined | 3.3 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | - | scFv16 | - |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | melatonin | small-molecule | - | - | 2022-03-02 | 55858 | |
Gi/o | αi1 | Human | - | 62 | β1 | Rat | γ2 | Bovine | cryo-EM | 7VGY | 7VGY_refined | 3.1 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | - | scFv16 | - |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
small-molecule | Agonist | melatonin | small-molecule | - | - | 2022-03-02 | 55858 | |
Gi/o | αi1 | Human | - | 61 | β1 | Rat | γ2 | Human | cryo-EM | 7VH0 | 7VH0_refined | 3.5 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | - | scFv16 | - |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
small-molecule | Agonist | melatonin | small-molecule | - | - | 2022-03-02 | 55858 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYF | - | 2.2 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP1 |
- |
amylin peptide
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYH | 7TYH_refined | 3.3 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Calcitonin human
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYI | 7TYI_refined | 3.3 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Amylin rat
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-30 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYL | 7TYL_refined | 3.3 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Amylin rat
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYN | 7TYN_refined | 2.6 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Calcitonin salmon
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-30 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYO | 7TYO_refined | 2.7 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Calcitonin human
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYW | 7TYW_refined | 3.0 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Calcitonin salmon
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7TYX | - | 2.6 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Amylin rat
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-30 | 55856 | |
Gs | αs | Human | - | 58 | β1 | Human | γ2 | Human | cryo-EM | 7TYY | 7TYY_refined | 3.0 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - | Nanobody-35 | - |
Calcitonin salmon
pubchem
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Human | - | 59 | β1 | Human | γ2 | Human | cryo-EM | 7TZF | - | 2.4 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | - |
Nanobody-35 RAMP3 |
- |
amylin peptide
|
peptide | Agonist | calcitonin, adrenomedullin, adrenomedullin 2/intermedin, amylin, calcitonin (salmon), β-CGRP, α-CGRP | peptide | - | - | 2022-03-23 | 55856 | |
Gs | αs | Bovine | - | 59 | β1 | Rat | γ2 | Bovine | cryo-EM | 7FIN | 7FIN_refined | 3.1 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Peptide-20
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-02-23 | 55873 | |
Gs | αs | Bovine | - | 60 | β1 | Rat | γ2 | Bovine | cryo-EM | 7FIY | 7FIY_refined | 3.4 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
tirzepatide
pubchem
gtoplig
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | - | - | 2022-03-02 | 55873 | |
Gs | αs | Human | Mini-Gs | 60 | β1 | Rat | γ2 | Bovine | cryo-EM | 7VAB | 7VAB_refined | 3.2 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
tirzepatide
pubchem
gtoplig
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | 55856 | |
Gs | αs | Bovine | - | 57 | β1 | Rat | γ2 | Bovine | cryo-EM | 7FIM | 7FIM_refined | 3.4 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
tirzepatide
pubchem
gtoplig
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | 55873 | |
Gs | αs | Human | Mini-Gs | 58 | β1 | Rat | γ2 | Bovine | cryo-EM | 7VBI | 7VBI_refined | 3.0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | - | - | - |
tirzepatide
pubchem
gtoplig
|
peptide | Agonist | glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) | peptide | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | 55856 | |
Gs | αs | Human | - | 53 | β1 | Rat | γ2 | Bovine | cryo-EM | 7V35 | 7V35_refined | 3.4 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | - | Nanobody-35 | - |
Peptide-20
|
peptide | Agonist | glucagon | peptide | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | 55856 | |
Gi/o | αi1 | Human | - | 61 | β1 | Human | γ2 |