TAS2R46 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 12, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 T 230 6x37 G.H5 L 248 G.H5.25
Polar TM6 K 226 6x33 G.H5 F 249 G.H5.26
Polar H8 K 284 8x48 G.H5 F 249 G.H5.26
Hydrophobic H8 K 284 8x48 G.H5 F 249 G.H5.26
Van-der-waals H8 K 284 8x48 G.H5 F 249 G.H5.26
Ionic TM3 K 109 3x53 G.H5 D 245 G.H5.22
Hydrophobic TM3 K 109 3x53 G.H5 D 245 G.H5.22
Hydrophobic TM5 M 209 5x72 G.H5 D 236 G.H5.13
Van-der-waals TM5 M 209 5x72 G.H5 D 236 G.H5.13
Hydrophobic TM5 L 202 5x65 G.H5 I 239 G.H5.16
Hydrophobic TM5 H 205 5x68 G.H5 I 239 G.H5.16
Van-der-waals TM5 H 205 5x68 G.H5 I 239 G.H5.16
Polar ICL2 R 123 - G.HN Q 31 G.HN.52
Hydrophobic TM5 M 209 5x72 G.H5 A 233 G.H5.10
Hydrophobic TM3 Y 106 3x50 G.H5 L 248 G.H5.25
Van-der-waals TM3 Y 106 3x50 G.H5 L 248 G.H5.25
Hydrophobic TM6 F 234 6x41 G.H5 L 248 G.H5.25
Ionic TM5 H 212 5x75 G.H5 D 232 G.H5.09
Polar TM5 H 212 5x75 G.H5 D 232 G.H5.09
Hydrophobic TM5 H 212 5x75 G.H5 D 232 G.H5.09
Van-der-waals TM5 H 212 5x75 G.H5 D 232 G.H5.09
Polar TM3 K 109 3x53 G.H5 N 242 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 N 242 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 242 G.H5.19
Hydrophobic TM6 V 223 6x30 G.H5 K 240 G.H5.17
Hydrophobic TM3 F 105 3x49 G.H5 C 246 G.H5.23
Polar TM6 S 220 6x27 G.H5 D 236 G.H5.13
Van-der-waals TM6 S 220 6x27 G.H5 D 236 G.H5.13
Hydrophobic TM7 G 282 7x56 G.H5 L 248 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 L 243 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 243 G.H5.20
Hydrophobic TM3 I 110 3x54 G.H5 C 246 G.H5.23
Polar H8 K 284 8x48 G.H5 G 247 G.H5.24
Hydrophobic TM6 V 231 6x38 G.H5 L 248 G.H5.25
Polar TM3 Y 106 3x50 G.H5 C 246 G.H5.23
Hydrophobic TM3 Y 106 3x50 G.H5 C 246 G.H5.23
Van-der-waals TM3 Y 106 3x50 G.H5 C 246 G.H5.23
Polar TM6 S 220 6x27 G.H5 K 240 G.H5.17
Hydrophobic TM6 S 220 6x27 G.H5 K 240 G.H5.17
Van-der-waals TM6 S 220 6x27 G.H5 K 240 G.H5.17
Hydrophobic TM3 I 110 3x54 G.H5 L 248 G.H5.25
Hydrophobic TM6 A 227 6x34 G.H5 L 243 G.H5.20
Ionic TM5 K 208 5x71 G.H5 D 232 G.H5.09
Polar TM5 K 208 5x71 G.H5 D 232 G.H5.09
Hydrophobic TM5 K 208 5x71 G.H5 D 232 G.H5.09
Van-der-waals TM5 K 208 5x71 G.H5 D 232 G.H5.09
Polar TM5 H 212 5x75 G.H5 K 228 G.H5.05
Hydrophobic TM2 A 44 2x39 G.H5 C 246 G.H5.23
Hydrophobic TM3 I 110 3x54 G.H5 N 242 G.H5.19
Ionic TM5 H 205 5x68 G.H5 D 236 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 236 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 236 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 236 G.H5.13
Hydrophobic TM3 K 109 3x53 G.H5 C 246 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 C 246 G.H5.23
Hydrophobic TM6 V 223 6x30 G.H5 F 249 G.H5.26
Van-der-waals TM6 V 223 6x30 G.H5 F 249 G.H5.26
Hydrophobic H8 N 283 8x47 G.H5 G 247 G.H5.24
Van-der-waals H8 N 283 8x47 G.H5 G 247 G.H5.24
Polar TM6 H 224 6x31 G.H5 K 240 G.H5.17
Hydrophobic TM6 H 224 6x31 G.H5 K 240 G.H5.17
Van-der-waals TM6 H 224 6x31 G.H5 K 240 G.H5.17
Aromatic TM5 H 212 5x75 G.H5 F 229 G.H5.06
Hydrophobic TM5 H 212 5x75 G.H5 F 229 G.H5.06
Van-der-waals TM5 H 212 5x75 G.H5 F 229 G.H5.06
Hydrophobic TM5 H 205 5x68 G.H5 T 235 G.H5.12
Hydrophobic TM5 M 209 5x72 G.H5 D 232 G.H5.09
Van-der-waals TM5 M 209 5x72 G.H5 D 232 G.H5.09
Ionic TM6 H 224 6x31 G.H5 D 236 G.H5.13
Polar TM6 H 224 6x31 G.H5 D 236 G.H5.13
Hydrophobic TM6 H 224 6x31 G.H5 D 236 G.H5.13
Van-der-waals TM6 H 224 6x31 G.H5 D 236 G.H5.13