ADGRL4 - Gq

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Jan. 14, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM6 S 615 6x37 G.H5 V 394 G.H5.26
Polar TM6 G 619 6x41 G.H5 N 392 G.H5.24
Hydrophobic TM6 G 619 6x41 G.H5 N 392 G.H5.24
Hydrophobic TM6 G 619 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 619 6x41 G.H5 L 393 G.H5.25
Van-der-waals ICL3 K 604 - G.S6 C 359 G.S6.01
Hydrophobic TM5 V 596 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 596 5x61 G.H5 L 393 G.H5.25
Polar TM2 R 459 2x46 G.H5 Y 391 G.H5.23
Aromatic TM2 R 459 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 459 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 459 2x46 G.H5 Y 391 G.H5.23
Ionic TM5 H 599 5x64 G.H5 D 381 G.H5.13
Polar TM5 H 599 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 599 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL3 P 605 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 P 605 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 S 615 6x37 G.H5 L 393 G.H5.25
Polar TM5 H 599 5x64 G.H5 Q 385 G.H5.17
Hydrophobic TM5 H 599 5x64 G.H5 Q 385 G.H5.17
Van-der-waals TM5 H 599 5x64 G.H5 Q 385 G.H5.17
Hydrophobic TM3 I 518 3x57 G.H5 N 387 G.H5.19
Hydrophobic TM3 V 519 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL3 K 604 - G.S6 P 361 G.S6.03
Hydrophobic ICL3 K 604 - G.H4 L 346 G.H4.16
Hydrophobic TM5 H 599 5x64 G.H5 L 384 G.H5.26
Van-der-waals TM5 H 599 5x64 G.H5 L 384 G.H5.26
Hydrophobic ICL3 L 603 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 L 603 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 518 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 518 3x57 G.H5 Y 391 G.H5.23
Polar TM6 C 616 6x38 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 515 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 515 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM6 S 615 6x37 G.H5 N 392 G.H5.24
Hydrophobic ICL3 L 603 - G.H5 Q 385 G.H5.17
Van-der-waals ICL3 L 603 - G.H5 Q 385 G.H5.17
Hydrophobic TM3 V 519 3x58 G.H5 L 384 G.H5.26